Pseudoporphyria induced by mefenamic acid

Ah, O'Hagan; Irvine, Alan D.; Ge, Allen; Walsh, Maureen

doi:10.1046/j.1365-2133.1998.2576p.x

Cited by 21 publications

(1 citation statement)

References 7 publications

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“…Erstmals wurden diese durch Howard et al in Victoria, Australien, bei 5 Patienten zwischen 34 und 85 Jahren 1985 beschrieben [5].Alle Patienten nahmen neben anderen Medikamenten Naproxen bei Gelenkbeschwerden ein. Ganz ähnliche Verläufe gelten für die in jüngerer Zeit erfolgten Berichte bei dem Einsatz von ASS/Carisoprodol, Oxaprozin, Nabumeton und Mefenamin-Säure [14,17,18,19,20]. Bei einem Patienten mit der Angewohnheit, den linken Arm häufig hinter seinen Rücken zu legen, zeigten sich die Hautveränderungen nur am rechten, den UV-Strahlen exponierten Arm.…”

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Naproxeninduzierte Pseudoporphyrie

et al. 2001

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A 12 year old boy developed scars at light-exposed areas following long-term therapy with naproxen for rheumatoid arthritis. Erythrocyte and urine porphyrin levels were not increased, and there was no evidence of increased photosensitivity. Pseudoporphyria is reported in 10-20% of those treated with naproxen for > 4 weeks. As compared to other nonsteroidal anti-inflammatory agents, the specific risk for naproxen is increased about 6fold. While the underlying abnormality has not been elucidated, formation of phototoxic metabolites in a subgroup of genetically predisposed individuals has been suggested as the most likely mechanism. Both dermatologists and rheumatologists should be aware of the risk of naproxen-induced pseudoporphyria and discontinue therapy early in order to avoid scar formation in light-exposed areas.

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