Pseudoporfiria induzida pela diálise tratada com N-acetilcisteína oral

Guiotoku, Marcelo Massaki; Pereira, Fabíola de Paula; Miot, Hélio Amante; Marques, Mariângela Esther Alencar

doi:10.1590/s0365-05962011000200031

Cited by 15 publications

(4 citation statements)

References 10 publications

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“…However, the response is usually slow, with the possibility of complications by secondary infection. Improvements in the lesions is usually gradual, with complete resolution in a period of months to years 15…”

Section: Discussionmentioning

confidence: 99%

Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report

et al. 2018

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Introduction: Pseudoporphyria is a rare photodermatosis with characteristics similar to those of porphyria cutanea tarda, without, however, presenting abnormalities in porphyrin metabolism. Its etiology is related to chronic kidney disease, ultraviolet radiation and certain medications. The aim of the present study is to describe a case of furosemide-related pseudoporphyria in a patient with chronic kidney disease. Case description: A 76-year-old male patient with stage 4 chronic kidney disease and in continuous use of furosemide presented ulcerated lesions with peripheral erythema and central hematic crust in the legs. On a skin infection suspicion, treatment with quinolone and neomycin sulfate was initiated, without improvement. A biopsy of the lesion was performed, with histopathological examination demonstrating findings compatible with porphyria, although the patient did not present high porphyrin levels. The diagnosis of furosemide-induced pseudoporphyria was then established, with medication suspension, and there was a significant improvement of the lesions. Discussion: There are few cases of pseudoporphyria described, but it is believed that this condition is underdiagnosed, especially in patients with chronic kidney disease. Both clinical and histopathological findings closely resemble porphyria, differentiating it from normal levels of porphyrin in plasma, urine, or feces. Conclusions: Although the lesions are mostly benign, they may increase the morbidity and mortality of these patients, so a proper diagnosis and early treatment are extremely important.

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Section: Discussionmentioning

confidence: 99%

Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report

et al. 2018

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“…daily for 8 weeks), a glutathione precursor, but some authors noticed recurrence when the drug was discontinued. [ 8 9 10 ] Chloroquine also has been tried with satisfactory results after 1-month.…”

Section: Discussionmentioning

confidence: 99%

Drug induced pseudoporphyria in CKD: A case report

Quaiser

Khan

2015

Indian J Nephrol

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Pseudoporphyria (PP) is used to describe a photodistributed bullous disorder with clinical and histologic features of porphyria cutanea tarda (PCT) but without accompanying biochemical porphyrin abnormalities. Medications, excessive sun and ultraviolet radiation exposure, have all been reported to develop PP. We report a case of PP in a 49-year-old man with CKD stage 3a, caused due to torsemide intake. This is probably the first reported case of PP developing in a dialysis naive patient CKD due to torsemide intake from India.

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“…Guiotoku et al . [4] observed a case related with hemodialysis and peritoneal dialysis but authors described a good response of the patient to oral N-acetyl-cysteine treatment. Relations between pseudoporphyria and dialysis were also presented by Felix et al .…”

Section: Discussionmentioning

confidence: 99%

Pseudoporphyria induced by hemodialysis

Bergler‐Czop

Brzeźińska-Wcisło

2014

pdia

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Pseudoporphyria is a condition identical to porphyria cutanea tarda (PCT) on clinical and histological grounds, but without any biochemical porphyrin abnormality. Excessive sunlight and UVA exposure (for example tanning beds), drugs such as: non-steroidal anti-inflammatory drugs, retinoids, antibiotics, diuretics and others are supposed to be etiological factors of pseudoporphyria. Cases of PCT and pseudoporphyria in patients with HCV infection and hemodialysed due to chronic renal failure were also described. Here, we describe a clinical case of a 57-year-old patient, who developed cutaneous changes on the face and the dorsal surfaces of hands clinically and histologically characteristic of PCT but with normal levels of urine porphyrins.

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Pseudoporfiria induzida pela diálise tratada com N-acetilcisteína oral

Cited by 15 publications

References 10 publications

Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report

Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report

Drug induced pseudoporphyria in CKD: A case report

Pseudoporphyria induced by hemodialysis

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