Pseudomyxoma Peritonei: Diagnosis and Management

Abstract

Abstract. Pseudomyxoma peritonei is a rare disease characterized by a large amount of mucinous ascites with peritoneal and omental implants. The etiology of the disease remains unclear. Different histological categories have been described: the benign, malignant, and the intermediate forms. It is commonly diagnosed incidentally at laparotomy. Most investigators agree that radical surgical debulking and appendectomy are the cornerstone of treatment, but the optimal management of the disease remains controversial. The role of intraoperative and intraperitoneal chemotherapy has been evaluated by a number of authors. The clinical outcomes vary widely between the different histological types and treatment modalities.

Management of Pseudomyxoma Peritonei Syndrome during Pregnancy

“…Incidence is one per million per year and encountered in 2 of 10,000 laparotomies with gelatinous masses called "jelly belly". 1 PMP is three to four times more common in women than in men. The median age of presentation is 54 years.…”

“…However if there is no abnormalities in appendix, we have to think that the source of PMP is from ovarian. 1,2 Symptoms may include abdominal or pelvic pain and or bloating, distension, digestive disorders, weight changes, increase girth and infertility. The disease is sometimes incidentally discovered during surgery for other conditions.…”

“…Only three pregnancies in patients with PMP have been reported to date. 1 Management of PMP during pregnancy is challenging, requiring a balance of concern for maternal survival and fetal health and wellbeing. The management plan, which may require induced abortion, is determined by the stage of pregnancy and the predicted behavior of the malignancy grade.…”

Histopathological discrepancy and variation of surgical management in mucinous ovarian cystadenoma and pseudomyxoma peritonei

“…PMP is a rare condition with an estimated incidence of approximately one per million per year and characterized by the production of vast amounts of mucinous fluid [4] , [5] . Peritoneal fluid and gravity help these cells move intra-abdominally [6] , [7] . Due to the disease's variable clinical appearance, diagnosing PMP can be confusing [8] .…”