Pseudomonas Skin Infection

Wu, Douglas C.; Chan, Wilson; Metelitsa, Andrei I.; Fiorillo, Loretta; Lin, Andrew N.

doi:10.2165/11539770-000000000-00000

Cited by 131 publications

(62 citation statements)

References 124 publications

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“…P. aeruginosa is known as a causative organism1,2,3. This organism is a gram-negative bacillus that can cause localized cutaneous infection to serious life-threatening systemic diseases4. Infections in healthy individuals are not usual.…”

Section: Discussionmentioning

confidence: 99%

Green Nail Syndrome Treated with the Application of Tobramycin Eye Drop

et al. 2014

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Green nail syndrome (chromonychia) is a nail disorder characterized by onycholysis and green-black discoloration of the nail bed. This condition is often associated with chronic paronychia. Pseudomonas aeruginosa is the most commonly identified organism in cultures from the affected area. Despite the various treatment options available, removal of the nail is still necessary in many cases. A 35-year-old man presented with dark-greenish discoloration of the nail plate and onycholysis on the left thumbnail. He had been treated with oral antifungal and antibiotic agents for several months; however, the lesion showed no improvement. The diagnosis of green nail syndrome was established after a positive bacterial culture, and on the basis of the antibiotic sensitivity test result, tobramycin eye drop (Tobrex®) was then prescribed. Three weeks later, the nail discoloration almost vanished but the onycholysis remained. Herein, we recommend the application of tobramycin eye drop as an easy and safe treatment option for green nail syndrome.

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Section: Discussionmentioning

confidence: 99%

Green Nail Syndrome Treated with the Application of Tobramycin Eye Drop

et al. 2014

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“…Pseudomonas aeruginosa is a regular cause of opportunistic nosocomial infections [187]. It is often involved in localised skin infections, green nail syndrome, and interdigital infection, colonises burn wounds, and may expand into a life-threatening systemic illness [225]. …”

Section: Pathogenesis Of Wounds and Skin Infections And The Use Ofmentioning

confidence: 99%

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Orchard

Vuuren

2017

Evidence-Based Complementary and Alternative Medicine

173

121

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Essential oils are one of the most notorious natural products used for medical purposes. Combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. At least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. This review explores the fundamental knowledge available on the antimicrobial properties against pathogens responsible for dermatological infections and compares the scientific evidence to what is recommended for use in common layman's literature. Also included is a review of combinations with other essential oils and antimicrobials. The minimum inhibitory concentration dilution method is the preferred means of determining antimicrobial activity. While dermatological skin pathogens such as Staphylococcus aureus have been well studied, other pathogens such as Streptococcus pyogenes, Propionibacterium acnes, Haemophilus influenzae, and Brevibacterium species have been sorely neglected. Combination studies incorporating oil blends, as well as interactions with conventional antimicrobials, have shown that mostly synergy is reported. Very few viral studies of relevance to the skin have been made. Encouragement is made for further research into essential oil combinations with other essential oils, antimicrobials, and carrier oils.

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“…P. aeruginosa is an especially bad actor, being the fourth most common nosocomial pathogen accounting for 10% of all hospital infections. P. aeruginosa infection remains a serious problem for patients hospitalized for cancer, AIDS, burns and cystic fibrosis [5-8]. …”

Section: Introductionmentioning

confidence: 99%

Arginine-rich self-assembling peptides as potent antibacterial gels

et al. 2012

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Hydrogel materials that display inherent activity against bacteria can be used to directly treat accessible wounds to prevent or kill existing infection. Hydrogels composed of self-assembling β-hairpin peptides, having a high content of arginine, were found to be extremely effective at killing both gram-positive and gram-negative bacteria, including multi-drug resistant P. aeruginosa. No added antibacterial agents are necessary to realize activity. Using self-assembling peptides for material construction allows facile structure-activity relationships to be determined since changes in peptide sequence at the monomer level are directly transposed to the bulk material's antibacterial properties. SAR studies show that arginine content largely influences the hydrogel's antibacterial activity, and influences their bulk rheological properties. These studies culminated in an optimized gel, composed of the peptide PEP6R (VKVRVRVRVDPPTRVRVRVKV). PEP6R gels prepared at 1.5 wt % or higher concentration, demonstrate high potency against bacteria, but are cytocompatible towards human erythrocytes as well as mammalian mesenchymal stem cells. Rheological studies indicate that the gel is moderately stiff and displays shear-thin recovery behavior, allowing its delivery via simple syringe.

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Pseudomonas Skin Infection

Cited by 131 publications

References 124 publications

Green Nail Syndrome Treated with the Application of Tobramycin Eye Drop

Green Nail Syndrome Treated with the Application of Tobramycin Eye Drop

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Arginine-rich self-assembling peptides as potent antibacterial gels

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