Pseudomonas infection of the catheter exit site successfully managed with topical acetic acid

Williams, Nigel; Wales, S.; Carlson, Gordon L

doi:10.1016/0261-5614(93)90035-3

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Since then, several articles have been published describing acetic acid for topical treatment. [12][13][14][15][16][17][18][19][20][21][22] In addition, acetic acid has been used with success for different types of otitis media. 23 We have discovered that not only does acetic acid kill planktonic bacteria but it also eradicates bacteria growing in biofilms.…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm Properties of Acetic Acid

Bjarnsholt

Alhede

Jensen

et al. 2015

Advances in Wound Care

135

151

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Bacterial biofilms are known to be extremely tolerant toward antibiotics and other antimicrobial agents. These biofilms cause the persistence of chronic infections. Since antibiotics rarely resolve these infections, the only effective treatment of chronic infections is surgical removal of the infected implant, tissue, or organ and thereby the biofilm. Acetic acid is known for its antimicrobial effect on bacteria in general, but has never been thoroughly tested for its efficacy against bacterial biofilms. In this article, we describe complete eradication of both Gram-positive and Gram-negative biofilms using acetic acid both as a liquid and as a dry salt. In addition, we present our clinical experience of acetic acid treatment of chronic wounds. In conclusion, we here present the first comprehensive and testing of acetic acid against bacterial biofilms.

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Section: Introductionmentioning

confidence: 99%

Antibiofilm Properties of Acetic Acid

Bjarnsholt

Alhede

Jensen

et al. 2015

Advances in Wound Care

135

151

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“…15 It is a weak organic acid that is active against Gram-positive and -negative organisms. 16 - 19 Previous studies have demonstrated its inhibitory and eradication action against bacteria in both planktonic and biofilm states. 18 , 19 It has also been used in the treatment of ear infections, 20 burn wounds, 21 and catheter-associated urinary tract infections.…”

Section: Introductionmentioning

confidence: 99%

“… 18 , 19 It has also been used in the treatment of ear infections, 20 burn wounds, 21 and catheter-associated urinary tract infections. 16 It has United States Food and Drug Administration approval for the therapeutic use of a 0.25% solution in bladder irrigation and a 2% solution for treating otitis externa. 18 A recent study demonstrated that it had an acceptable safety profile and patient tolerance when used as an adjunct to debridement in PJIs.…”

Section: Introductionmentioning

confidence: 99%

The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection

Tsang

Gwynne

Gallagher

et al. 2018

Bone & Joint Research

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ObjectivesPeriprosthetic joint infection following joint arthroplasty surgery is one of the most feared complications. The key to successful revision surgery for periprosthetic joint infections, regardless of treatment strategy, is a thorough deep debridement. In an attempt to limit antimicrobial and disinfectant use, there has been increasing interest in the use of acetic acid as an adjunct to debridement in the management of periprosthetic joint infections. However, its effectiveness in the eradication of established biofilms following clinically relevant treatment times has not been established. Using an in vitro biofilm model, this study aimed to establish the minimum biofilm eradication concentration (MBEC) of acetic acid following a clinically relevant treatment time.Materials and MethodsUsing a methicillin-sensitive Staphylococcus aureus (MSSA) reference strain and the dissolvable bead assay, biofilms were challenged by 0% to 20% acetic acid (pH 4.7) for ten minutes, 20 minutes, 180 minutes, and 24 hours.ResultsThe MBEC of acetic acid was found to be: 15%, 11%, 3.2%, and 0.8% following a ten-minute, 20-minute, 180-minute, and 24-hour treatment, respectively.ConclusionThis study found that the MBEC of acetic acid following a 10- or 20-minute treatment time exceeded its safety threshold, making these concentrations unsuitable as a topical debridement adjunct. However, a clinically acceptable concentration (5%) was still found to eliminate 96.1% of biofilm-associated MSSA following a 20-minute treatment time.Cite this article: S. T. J. Tsang, P. J. Gwynne, M. P. Gallagher, A. H. R. W. Simpson. The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection. Bone Joint Res 2018;7:517–523. DOI: 10.1302/2046-3758.78.BJR-2018-0045.R1

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Incidence, Complications and Novel Treatment Strategies: Joint Arthroplasty

Simpson

2022

Musculoskeletal Infection

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Pseudomonas infection of the catheter exit site successfully managed with topical acetic acid

Cited by 4 publications

References 6 publications

Antibiofilm Properties of Acetic Acid

Antibiofilm Properties of Acetic Acid

The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection

Incidence, Complications and Novel Treatment Strategies: Joint Arthroplasty

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