Pseudomonas Alcaligenes <i>Endocarditis</i>

Valenstein, Paul; Bardy, Gust H.; Cox, C. Christine; Zwadyk, Peter

doi:10.1093/ajcp/79.2.245

Cited by 27 publications

(23 citation statements)

References 2 publications

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“…This is similar to the results of Motamedifar et al 6 and Mattner et al 9 It is evident from the literature that the contaminating microorganisms identified in our study have been implicated as opportunistic pathogens that could lead to clinically significant infections in immunocompromised patients. [43][44][45][46][47] This is especially important at CHBAH since a large proportion of South African patients are immunocompromised and susceptible to opportunistic infections. 48 The literature shows that the inappropriate labelling of medication is a cause of medication administration errors in general 26,27 and in anaesthetic practice.…”

Section: Resultsmentioning

confidence: 99%

Microbial contamination and labelling of self-prepared, multi-dose phenylephrine solutions used at a teaching hospital

Heever

Scribante

Perrie

et al. 2016

Southern African Journal of Anaesthesia and Analgesia

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Background: Common practice at Chris Hani Baragwanath Academic Hospital (CHBAH) is to use boluses from a self-prepared, multi-dose phenylephrine solution to treat spinal anaesthesia-induced hypotension in patients undergoing a Caesarean section. The aims of this study were to determine if there was microbial contamination of the solutions and to evaluate whether healthcare workers adhered to appropriate labelling and aspiration practices. Methods: A sample was collected and the labelling data were documented from the solutions found in the two obstetric theatres at CHBAH over a three-month period. The samples were sent to a laboratory for microbial investigation. Results: Microbial contamination was identified in 6.4% of samples collected. The name of the solution was indicated on 100% of the containers and the concentration of the solution was on 96.4%. The date the solution was prepared was indicated on 74.6% of containers and the time the solution was prepared was on 57.3%. Only 8.2% of healthcare workers who prepared the solution confirmed it by placing a signature on the container. Labelling data were written directly on 100% of the containers and a spikedevice was used in 64.5% of the containers. Conclusions: This study demonstrated microbial contamination of the solution and may indicate an infection hazard. Healthcare workers also did not adhere to appropriate labelling and aspiration practices. This is important for all patients from a patient safety perspective and the need to improve quality of care.

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Section: Resultsmentioning

confidence: 99%

Microbial contamination and labelling of self-prepared, multi-dose phenylephrine solutions used at a teaching hospital

Heever

Scribante

Perrie

et al. 2016

Southern African Journal of Anaesthesia and Analgesia

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“…Bacillus licheniformis (which is a common bacterium in soils) detected both in the well and pool waters can also be opportunistic pathogen, can cause sepsis [33], aortic valve endocarditis [34], and food poisoning [35]. Pseudomonas alcaligenes detected only in the pool water was initially described as opportunistic pathogen, which causes endocarditis [36], although since then it has been detected from numerous environmental samples. One of the closest relative of strain FDRGB2b is the type strain of Brevundimonas vesicularis (97.24%), which is also a facultative pathogen that causes endocarditis [37], peritonitis [38], and septic arthritis [39].…”

Section: Resultsmentioning

confidence: 99%

Microbiological investigations on the water of a thermal bath at Budapest

Szuróczki¹,

Kéki²,

Káli³

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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Thermal baths are unique aquatic environments combining a wide variety of natural and anthropogenic ecological factors, which also appear in their microbiological state. There is limited information on the microbiology of thermal baths in their complexity, tracking community shifts from the thermal wells to the pools. In the present study, the natural microbial community of well and pool waters in Gellért bath was studied in detail by cultivation-based techniques. To isolate bacteria, 10% R2A and minimal synthetic media (with "bath water") with agar-agar and gellan gum were used after prolonged incubation time; moreover, polyurethane blocks covered with media were also applied. Strains were identified by sequencing their 16S rRNA gene after grouping them by amplified rDNA restriction analysis. From each sample, the dominance of Alphaproteobacteria was characteristic though their diversity differed among samples. Members of Actinobacteria, Firmicutes, Beta-and Gammaproteobacteria, Deinococcus-Thermus, and Bacteroidetes were also identified. Representatives of Deinococcus-Thermus phylum appeared only in the pool water. The largest groups in the pool water belonged to the Tistrella and Chelatococcus genera. The most dominant member in the well water was a new taxon, its similarity to Hartmannibacter diazotrophicus as closest relative was 93.93%.

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“…The isolates which are likely to be pathogenic include strain AP1 which is phylogenetically close to Cupriavidus pauculus which causes human infections sporadically and were isolated earlier from a variety of human clinical sources and also from drinking water sources [15] (Table 4); strains GD5 and NG1 which are phylogenetically close to Acinetobacter johnsonii which causes vascular catheter-related bloodstream infection were isolated from clinical specimens and milk [16] (Table 4); strains AP2, AP4, GD2, JD4, KL3, KL4, MB3, R1, WN1, WN3, WN4, and WN5 which are phylogenetically close to Acinetobacter junii which causes septicemia, meningitis, peritonitis, and so forth were isolated from human clinical specimens like urine [17] (Table 4); strain MB4 which is phylogenetically close to Acinetobacter ursingii which causes bacteremia was isolated from blood [18] (Table 4); strain GD4 which is phylogenetically close to Aeromonas hydrophila subsp. Hydrophila which causes acute diarrheal disease was isolated from humans, animals, fish, and fresh water [11, 19] (Table 4); strain NG2 which is phylogenetically close to Citrobacter freundii which causes opportunistic infections was isolated from canal water [20] (Table 4); strain NR2 which is phylogenetically close to Pseudomonas aeruginosa which causes several infections in immunocompromised individuals was isolated from wide variety habitats including clinical samples and also from drinking water samples [4, 5] (Table 4); strains R6, R7, and R23 which are phylogenetically close to Pseudomonas alcaligenes which causes endocarditis occasionally were isolated from soil, water, and also from clinical samples [21] (Table 4); strains D22, GD6, MB2, and MK3 which are phylogenetically close to Pseudomonas otitidis which causes inflammation of the ear were isolated from the ear [22] (Table 4); strain D12 which is phylogenetically close to Bacillus anthracis which causes anthrax disease was isolated from sheep blood (Table 4); strain R5 which is phylogenetically close to Bacillus cereus which causes food poisoning was isolated from the soil and also food materials [23] (Table 4); and strain JU1 which is phylogenetically close to Bacillus infantis which causes sepsis was isolated from clinical specimens [24] (Table 4). …”

Section: Resultsmentioning

confidence: 99%

Identification of Opportunistic Pathogenic Bacteria in Drinking Water Samples of Different Rural Health Centers and Their Clinical Impacts on Humans

Pindi

Yadav

Shanker

2013

BioMed Research International

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International drinking water quality monitoring programs have been established in order to prevent or to reduce the risk of contracting water-related infections. A survey was performed on groundwater-derived drinking water from 13 different hospitals in the Mahabubnagar District. A total of 55 bacterial strains were isolated which belonged to both gram-positive and gram-negative bacteria. All the taxa were identified based on the 16S rRNA gene sequence analysis based on which they are phylogenetically close to 27 different taxa. Many of the strains are closely related to their phylogenetic neighbors and exhibit from 98.4 to 100% sequence similarity at the 16S rRNA gene sequence level. The most common group was similar to Acinetobacter junii (21.8%) and Acinetobacter calcoaceticus (10.9%) which were shared by 7 and 5 water samples, respectively. Out of 55 isolates, only 3 isolates belonged to coliform group which are Citrobacter freundii and Pantoea anthophila. More than half (52.7%, 29 strains) of the phylogenetic neighbors which belonged to 12 groups were reported to be pathogenic and isolated from clinical specimens. Out of 27 representative taxa are affiliated have eight representative genera in drinking water except for those affiliated with the genera Exiguobacterium, Delftia, Kocuria, and Lysinibacillus.

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Pseudomonas Alcaligenes Endocarditis

Abstract: Pseudomonas alcaligenes is a common soil and water inhabitant that has rarely been proven a human pathogen. We describe a fatal case of Pseudomonas alcaligenes endocarditis. The need for accurate identification of unusual organisms isolated in a clinical setting are discussed.

Cited by 27 publications

References 2 publications

Microbial contamination and labelling of self-prepared, multi-dose phenylephrine solutions used at a teaching hospital

Microbial contamination and labelling of self-prepared, multi-dose phenylephrine solutions used at a teaching hospital

Microbiological investigations on the water of a thermal bath at Budapest

Identification of Opportunistic Pathogenic Bacteria in Drinking Water Samples of Different Rural Health Centers and Their Clinical Impacts on Humans

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