Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

Abstract

Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes P. aeruginosa a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. In this review, we review the important acute and chronic infections caused by this pathogen. We next discuss various animal models which have been developed to evaluate P. aeruginosa pathogenesis and assess therapeutics against this pathogen. Next, we review current treatments (antibiotics and vaccines) and provide an overview of their efficacies and their limitations. Finally, we highlight exciting literature on novel antibiotic-free strategies to control P. aeruginosa infections.

Chemical Composition and Biological Activities of Essential Oils of Four Asarum Species Growing in Vietnam

“…Pseudomonas aeruginosa is a Gram-negative, aerobic, extremely versatile, antibiotic-resistant bacteria and causes infections in the blood, lungs, or other parts after surgery [ 29 ]. Only A. geophilum EO showed activity against Pseudomonas aeruginosa with a MIC value of 200 μg/mL.…”

Immunogenic Potential and Therapeutic Efficacy of Multi‐Epitope Encapsulated Silk Fibroin Nanoparticles against Pseudomonas aeruginosa‐Mediated Urinary Tract Infections

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Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms

“…These bacteria were selected due to their propensity to form biofilms, which cause nosocomial infections. 39,40 First, the short-term (3 h) antibacterial efficacy of the QC NPs was assessed against planktonic bacteria using the colony-counting assay. It is found that the QC NPs (5 μg mL −1 ) exhibited remarkable antibacterial properties against both P. aeruginosa and S. aureus, resulting in 6.77-log and 3.42-log reduction, respectively, in the number of bacterial colonies formed (Fig.…”