Pseudomonas aeruginosa in the healthcare facility setting

Abstract

Pseudomonas aeruginosa is a Gram-negative pathogen that has become an important cause of infection in humans and can be associated with significant morbidity and mortality.Severe infections usually affect immunocompromised patients or those with chronic debilitating diseases. Its significance as a pathogen is exacerbated by its resistance to antibiotics, virulence factors and its ability to adapt to a wide range of environments. P. aeruginosa can have multiple intrinsic or acquired mechanisms of resistance, frequently with high resistance rates to various antimicrobial classes. In recent years, the worldwide spread of the so-called 'high-risk clones' of multidrug-resistant or extensively drugresistant P. aeruginosa has become a public health threat that needs to be studied and managed with urgency and determination. Among Gram-negative infections, P. aeruginosa is one of the most common Gramnegative bacteria causing nosocomial and healthcare-associated infections in hospitalised patients. According to WHO guidelines, measures to prevent the transmission of multiresistant P. aeruginosa in healthcare facilities should include at least hand hygiene (with the appropriate use of alcohol-based solutions), contact precautions, patient isolation (single room or cohort), environmental cleanliness and surveillance.

Phylogenic diversity some of the pseudomonas Isolate from wound infection in Babylon province

“…The spread of multidrug-resistant P. aeruginosa is particularly concerning. Over recent years, the worldwide spread of so-called "high-risk clones" of multidrug-resistant or extensively drug-resistant (MDR/XDR) P. aeruginosa has become a public health threat that needs to be urgently and decisively studied and managed (Spagnolo et al, 2021). The result of our study was closed to Al-Muhannak (2020) who found that Levofloxacin resistance 70% and similar to the result of Mohammed (2012) which was 69.3%.…”

Evaluation of Multidrug-Resistant P. aeruginosa in Healthcare Facility Water Systems

“…The spread of multidrug-resistant P. aeruginosa is particularly concerning. Over recent years, the worldwide spread of so-called “high-risk clones” of multidrug-resistant or extensively drug-resistant (MDR/XDR) P. aeruginosa has become a public health threat that needs to be urgently and decisively studied and managed [ 3 ].…”

“…Healthcare-acquired infections (HAIs), particularly in the critical care setting, have become increasingly common over recent decades, with Gram-negative bacterial infections presenting the highest incidence among them [ 1 ]. P. aeruginosa is one of the most frequent and serious causes of HAIs (e.g., respiratory and urinary tract, skin and soft tissues, ear and eye infections, and bacteriemia), which particularly affect immunocompromised patients [ 2 , 3 , 4 ].…”

Genome-Wide Identification of Pseudomonas aeruginosa Genes Important for Desiccation Tolerance on Inanimate Surfaces

“…Factors that contribute to the prevalence of these infections are the immunosuppressed status of the patients, the intrinsic resistance of P. aeruginosa to antimicrobials and disinfectants, and the prevalence of P. aeruginosa in the environment ( 2 ). Reservoirs for P. aeruginosa in the health care setting include moist surfaces such as sinks, faucets, drains, and medical equipment such as ventilators and endoscopes ( 3 – 6 ). Contamination of these surfaces is promoted by the propensity of P. aeruginosa to grow as biofilms, which have enhanced resistance properties that hamper decontamination efforts.…”