Pseudolymphoma Syndrome

Abstract

A transient dermatologic abnormality which gave a histologic picture compatible with malignant lymphoma is described. The clinical manifestations included diarrhea, hepatosplenomegaly, moderate lymph node enlargement without histopathological changes and evidence of involvement of the reticulo-endothelial system. Both the dermatologic and gastrointestinal disorders appeared approximately 1 year after discontinuation of treatment with diphenylhydantoin, which the patient had taken for 2 years. The possible association between the transient abnormality and the previous diphenylhydantoin therapy justifies the classification of this case as ‘pseudolymphoma syndrome’.

Cefuroxime Axetil Related DRESS (drug reaction with eosinophilia and systemic symptoms) Syndrome

“…Dress syndrome has been described firstly after the use of anti-epileptic drugs. Therefore, it has been named as hypersensitivity syndrome associated with anticonvulsant drug or drug associated pseudolymphoma (3,4). Anti-epileptics and sulfonamides are the most common drugs that cause DRESS syndrome although many drugs can cause it.…”