Pseudohypertrophy of the Calf Muscles in a Patient with Diabetic Neuropathy: A Case Report

Lee, Eun Jin; Lee, Young Hwan; Jung, Kyung-Jae; Park, Young Chan; Kim, Ho Kyun; Kim, Ok Dong

doi:10.3348/jkrs.2007.57.3.287

Cited by 3 publications

(4 citation statements)

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“…Compared to thermal ablative modalities, IRE is not susceptible to heat sink from nearby vessels, has a shorter treatment time, and can be more precisely controlled [13]. The generated ablative zone in IRE has well-defined margins that demarcate ablated and non-ablated tissue, allowing for precise control [49,50]. This ablative zone resolves rapidly with little scarring or damage to the underlying noncellular matrix including preservation of adjacent vessels, ducts, and nerves [49][50][51].…”

Section: Discussionmentioning

confidence: 99%

“…The generated ablative zone in IRE has well-defined margins that demarcate ablated and non-ablated tissue, allowing for precise control [49,50]. This ablative zone resolves rapidly with little scarring or damage to the underlying noncellular matrix including preservation of adjacent vessels, ducts, and nerves [49][50][51]. More recently, studies have shown that mild hyperthermia results from IRE [19,27,[52][53][54].…”

Section: Discussionmentioning

confidence: 99%

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Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice

Rojo

Perez

Damasco

et al. 2021

International Journal of Hyperthermia

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Background: Metastatic prostate cancer in bone is difficult to treat as the tumor cells are relatively resistant to hormonal or chemotherapies when compared to primary prostate cancer. Irreversible electroporation (IRE) is a minimally invasive ablation procedure that has potential applications in the management of prostate cancer in bone. However, a common limitation of IRE is tumor recurrence, which arises from incomplete ablation that allows remaining cancer cells to proliferate. In this study, we combined IRE with radium-223 (Ra-223), a bone-seeking radionuclide that emits short track length alpha particles and thus is associated with reduced damage to the bone marrow and evaluated the impact of the combination treatment on bone-forming prostate cancer tumors. Methods: The antitumor activity of IRE and Ra-223 as single agents and in combination was tested in vitro against three bone morphogenetic protein 4 (BMP4)-expressing prostate cancer cell lines (C4-2B-BMP4, Myc-CaP-BMP4, and TRAMP-C2-BMP4). Similar evaluation was performed in vivo using a bone-forming C4-2B-BMP4 tumor model in nude mice. Results: IRE and Ra-223 as monotherapy inhibited prostate cancer cell proliferation in vitro, and their combination resulted in significant reduction in cell viability compared to monotherapy. In vivo evaluation revealed that IRE with single-dose administration of Ra-233, compared to IRE alone, reduced the rate of tumor recurrence by 40% following initial apparent complete ablation and decreased the rate of proliferation of incompletely ablated tumor as quantified in Ki-67 staining (53.58 ± 16.0% for IRE vs. 20.12 ± 1.63%; for IRE plus Ra-223; p ¼ 0.004). Histological analysis qualitatively showed the enhanced killing of tumor cells adjacent to bone by Ra-223 compared to those treated with IRE alone. Conclusion: IRE in combination with Ra-223, which enhanced the destruction of cancer cells that are adjacent to bone, resulted in reduction of tumor recurrence through improved clearance of proliferative cells in the tumor region.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice

Rojo

Perez

Damasco

et al. 2021

International Journal of Hyperthermia

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“…Lee et al. [7] described the association of denervation pseudohypertrophy of calf muscles with diabetic neuropathy. The pathophysiology of the fatty infiltration of denervation pseudohypertrophy has been reported [4] .…”

Section: Discussionmentioning

confidence: 99%

“…These features enable the differentiation of hypertrophy from pseudohypertrophy. Coexisting denervation hypertrophy [3] or atrophy [7] with denervation pseudohypertrophy has been reported. Other causes of muscle hypertrophy include overuse of the muscle and compensatory hypertrophy of the muscle as a response to functional loss of other muscles [12] .…”

Section: Discussionmentioning

confidence: 99%

Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy

Wong¹,

Chow²,

Lui³

et al. 2017

Radiology Case Reports

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Denervation of muscle usually leads to muscle atrophy with fatty replacement but, uncommonly, also results in muscle hypertrophy or pseudohypertrophy with fatty replacement. We report the ultrasonographic and magnetic resonance imaging (MRI) findings of a patient with diffuse fatty infiltration of calf muscles as a result of denervation pseudohypertrophy. The elevated fasting glucose, neurogenic electromyographic changes, and muscle atrophy with adipose tissue infiltration are consistent with diabetic neuropathy as the cause of denervation pseudohypertrophy. Lumbosacral radiculopathy and plexopathy were excluded by MRI. The imaging features reported in the literature are reviewed. The important differential diagnosis of infiltrating lipoma and denervation hypertrophy, as well as other causes of monomelic hypertrophy or swelling, is discussed. This case report demonstrates the importance of MRI, with clinical, biochemical, electrophysiological, and histologic correlation in the diagnosis of denervation pseudohypertrophy. Correct diagnosis of denervation pseudohypertrophy has an important role in guiding further investigations and treatment of the disease and the underlying cause.

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Electroporation combined with intelligent drug delivery promising new and clean approach to cancer treatment

Aghayari

2023

Results in Engineering

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Pseudohypertrophy of the Calf Muscles in a Patient with Diabetic Neuropathy: A Case Report

Cited by 3 publications

References 0 publications

Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice

Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice

Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy

Electroporation combined with intelligent drug delivery promising new and clean approach to cancer treatment

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