Pseudohyperkalemia in serum: the phenomenon and its clinical magnitude

Sevastos, Nikolaos; Theodossiades, G.; Efstathiou, Stamatis P.; Papatheodoridis, George V.; Manesis, Emanuel K.; Archimandritis, Athanasios

doi:10.1016/j.lab.2005.11.008

Cited by 52 publications

(49 citation statements)

References 12 publications

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“…In the clotting process, platelets undergo aggregation and degranulation while also releasing potassium. 2,3 As a result, serum potassium is higher (0.36 ± 18 mEq/L) compared with a sample collected in plasma. 4 This has also been noted in patients with significant erythrocytosis and leukocytosis.…”

Section: Discussionmentioning

confidence: 97%

Reverse Pseudohyperkalemia in a Patient with Chronic Lymphocytic Leukemia

Avelar

2014

TPJ

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Section: Discussionmentioning

confidence: 97%

Reverse Pseudohyperkalemia in a Patient with Chronic Lymphocytic Leukemia

Avelar

2014

TPJ

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“…A quick root cause analysis should be performed in conjunction with laboratory personnel to identify the factors leading to pseudohyperkalemia and appropriate measures should be taken in order to avoid any unnecessary and dangerous treatment to the patient. [7] Clinicians should be aware of the possibility of pseudohyperkalemia masking true hypokalemia, depriving the patient of required potassium replacement. Clinicians should also be familiar with how hemolysis is detected in their own laboratories, especially in smaller hospitals.…”

Section: Discussionmentioning

confidence: 99%

Root cause analysis of pseudohyperkalemia in a patient with focal segmental glomerulosclerosis: A case report

Talluri

Talluri²

2017

CRIM

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Pseudohyperkalemia, also known as factitious or spurious hyperkalemia, is predominantly due to hemolysis during the collection process of the specimen. Pseudohyperkalemia is a condition in which the falsely elevated potassium can cause significant clinical dilemma as patients may be given unnecessary and harmful treatment for hyperkalemia. In addition, pseudohyperkalemia can also mask hypokalemia resulting in patients potentially not receiving adequate potassium replacement. Thus, it is pivotal for clinicians and laboratory personnel to have a high index of suspicion for this condition in order for the patient to receive appropriate treatment. We present a case of pseudohyperkalemia without obvious hemolysis due to the use of a 23-gauge needle blood draw in a patient with stage IV chronic kidney disease from focal segmental glomerulosclerosis.

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“…Active research failed to find a cause of hyperkalemia, therefore pseudohyperkalemia was suspected and plasma potassium level was measured to confir m the diagnosis. The phenomenon of pseudohyperkalemia was first reported in 1955, and has been commonly observed in patients with severe thrombocytosis, erythrocytosis and the presence of activated platelets [10] . It is characterized by a marked elevation of serum potassium concentration with normal plasma potassium level.…”

Section: Discussionmentioning

confidence: 99%

A latent form of essential thrombocythemia presenting asportal cavernoma

Cai¹,

Zhou²,

Hong³

et al. 2009

WJG

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Essential thrombocythemia is frequently associated with abdominal thrombotic complications including portal cavernoma as a consequence of chronic portal vein thrombosis. Essential thrombocythemia in a latent form is difficult to identify at onset due to the absence of an overt disease phenotype. In the presented case report, the diagnosis of essential thrombocythemia was initially missed because the typical disease phenotype was masked by bleeding and hypersplenism. The correct diagnosis was only reached when the patient experienced persistent thrombocytosis and pseudohyperkalemia after a shunt operation.

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Pseudohyperkalemia in serum: the phenomenon and its clinical magnitude

Cited by 52 publications

References 12 publications

Reverse Pseudohyperkalemia in a Patient with Chronic Lymphocytic Leukemia

Reverse Pseudohyperkalemia in a Patient with Chronic Lymphocytic Leukemia

Root cause analysis of pseudohyperkalemia in a patient with focal segmental glomerulosclerosis: A case report

A latent form of essential thrombocythemia presenting asportal cavernoma

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