Pseudoginsenoside-F11 attenuates cognitive impairment by ameliorating oxidative stress and neuroinflammation in d‑galactose-treated mice

Zhang, Zhen; Yang, Hanlin; Yang, Jingyu; Xie, Jun; Xu, Jiaoyan; Liu, Chen; Wu, Chunfu

doi:10.1016/j.intimp.2018.11.026

Cited by 32 publications

(19 citation statements)

References 43 publications

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“…The PAE contains an abundance of flavonoids, phenols, and saponins according to the analysis of bioactive components. In the previous studies, the saponins extracted from natural products could improve cognitive deficits in SAMP8 mice [46], protect splenocytes and thymocytes in an ageing rat model induced by d-gal [33], and attenuate d-gal-induced ageing in rats by activating FOXO3a and Nrf2 pathways [43]. Luteolin reduced inflammatory in the brain of senescent mice [47] and showed neuroprotective activity of various brain disorders [48], and rutin could also protect ageing-related metabolic dysfunction [49].…”

Section: Discussionmentioning

confidence: 96%

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

Sun

et al. 2020

IJMS

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We aimed to study the effects of an ethyl acetate fraction of Physalis alkekengi (PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated β-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Overall, this study showed the potential application of PAE for the prevention or treatment of ageing-associated disorders.

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Section: Discussionmentioning

confidence: 96%

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

Sun

et al. 2020

IJMS

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“…Aggregation of reactive oxygen species (ROS) triggers flap necrosis ( Storz and Imlay, 1999 ). Studies have reported that PF11 treatment alleviates cognitive impairment by suppressing oxidative stress in d-galactose-treated mice ( Zhang et al, 2019 ). In our study, we observed that PF11 increased the levels of anti-oxidative stress related proteins SOD1, HO1, and eNOS in the random skin flaps implying that PF11 has anti-oxidative stress effects.…”

Section: Discussionmentioning

confidence: 99%

Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway

et al. 2021

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Random-pattern skin flap is widely used in tissue reconstruction. However, necrosis occurring in the distal part of the flap limits its clinical application to some extent. Activation of autophagy has been considered as an effective approach to enhance the survival of skin flaps. Pseudoginsenoside F11 (PF11), an ocotillol-type saponin, is an important component of Panax quinquefolium which has been shown to confer protection against cerebral ischemia and alleviate oxidative stress. However, it is currently unknown whether PF11 induces autophagy to improve the survival of skin flaps. In this study, we investigated the effects of PF11 on blood flow and tissue edema. The results of histological examination and western blotting showed that PF11 enhanced angiogenesis, alleviated apoptosis and oxidative stress, thereby improving the survival of the flap. Further experiments showed that PF11 promoted nuclear translocation of TFEB and by regulating the phosphorylation of AMPK. In summary, this study demonstrates that PF11 activates autophagy through the AMPK-TFEB signal pathway in skin flaps and it could be a promising strategy for enhancing flap viability.

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“…Chikusetsu saponin IVa, a major active triterpenoid saponin in Panax japonicus , inhibited NLRP3 inflammasome activation, hence ameliorating obesity and neuroinflammation in macrophages, adipocytes, primary neurons, and postoperative cognitive dysfunction rats [ 75 , 76 ]. PF11, pseudoginsenoside, in Panax quinquefolius and saponins in Panax notoginseng inhibited NLRP3 inflammasome initiation, attenuating age-related neuroinflammation in macrophages and neurons [ 77 , 78 ].…”

Section: Inhibitory Role Of Ginseng In Inflammasome Activationmentioning

confidence: 99%

Potential benefits of ginseng against COVID-19 by targeting inflammasomes

2022

Journal of Ginseng Research

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Pseudoginsenoside-F11 attenuates cognitive impairment by ameliorating oxidative stress and neuroinflammation in d‑galactose-treated mice

Cited by 32 publications

References 43 publications

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway

Potential benefits of ginseng against COVID-19 by targeting inflammasomes

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