Pseudoexfoliation in the Reykjavik Eye Study: prevalence and related ophthalmological variables

Abstract

. Purpose: To examine the age and sex‐specific prevalence of pseudoexfoliation syndrome (PEX) and its relationship with some ophthalmological variables. Methods: We carried out a population‐based study using a random sample taken from the national population census for citizens of Reykjavik, aged ≥ 50 years. A total of 1045 individuals participated in all parts of the study. Pseudoexfoliation was established by slit‐lamp examination with a maximally dilated pupil carried out by two experienced ophthalmologists, who were masked to one another’s results except in cases of disagreement where they had to reach a consensus. Results: In all, 108 (10.7%) persons were found to have PEX in at least one eye. Prevalence increased from 2.5% in those aged 50–59 years to 40.6% in those aged ≥ 80 years. Women were more frequently affected than men (12.3% versus 8.7%). This difference remained statistically significant after controlling for the effect of age (p < 0.001). Eyes with PEX were found to have higher intraocular pressure (IOP) than eyes without PEX (p < 0.05). However, PEX was not found to be related to central corneal thickness, anterior chamber depth, lens thickness, nuclear lens opacifications or optic disc morphology in a multivariate model. Conclusions: Pseudoexfoliation is an age‐related phenomenon commonly found in Iceland. It is more commonly found in women than in men and is associated with elevated IOP.

Evaluation of anterior segment parameters in patients with pseudoexfoliation syndrome using Scheimpflug imaging

“…Results reported in the literature have varied with respect to the CCT in pseudoexfoliative eyes. Arnarsson et al (9) found that PXS was not associated with CCT. Rüfer et al (24) determined that CCT was not significantly different among primary open-angle glaucoma, pseudoexfoliative glaucoma, and control groups, but patients with low-tension glaucoma had significantly lower CCT than that in the controls.…”

“…However, there are conflicting studies about central corneal thickness (CCT) in patients with PXS or pseudoexfoliative glaucoma. Most studies have reported similar CCT in PXS and normal eyes (9)(10)(11)(12)(13) , but some authors have reported a thinner (14,15) or thicker (16,17) CCT in PXS eyes than in normal eyes.…”

Comparison of central corneal thickness, corneal curvature and axial length values in pseudoexfoliation cases with or without cataract

“…Bu beneklerin elastik mikrofibriller içerdiğine inanılmaktadır. PES tek ya da çift taraflı olabilen, sıklığı yaşla artan bir hastalıktır (1 Çalışmaya alınan olguların düzeltilmiş ve düzeltilmemiş görme keskinlikleri, göz içi basıncı ölçümü, biyomikroskopla ön segment muayenesi, kataraktın engel olmadığı durumlarda indirekt oftalmoskopi ile fundus muayenesi, kataraktın engel olduğu durumlarda ise B-mod ultrasonografi ile arka segment incelemesi yapıldı.…”

Pseudoexfoliation and Blood Flow Abnormalities

“…Many studies, such as the Thessaloniki Eye Study 2 and Blue Mountain Eye Study, 3 have found that pseudoexfoliation syndrome prevalence varies from 2.3 to 11.9% amongst different populations. [4][5][6][7][8][9][10][11][12][13] Furthermore, 14.2 to 55.1% of patients with pseudoexfoliation syndrome are likely to progress into openangle glaucoma. 2,14 The Early Manifest Glaucoma found that pseudoexfoliation is a strong predictor of glaucoma progression independent of elevated intraocular pressures and other risk factors.…”