2017
DOI: 10.1111/ced.13072
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Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen

Abstract: Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86-year-old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with thin mica-like scales involving his glans penis. Histology of the lesion showed hyperkeratosis, parakeratosis, epidermal acanthosis and papillomatosis with no evidence of dysplasia. Immunohistoch… Show more

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Cited by 12 publications
(11 citation statements)
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“…Pseudoepitheliomatous, keratotic, and micaceous balanitis in fact can resemble both clinically and histologically genital hypertrophic lichen sclerosus et atrophicus [7]; both have a risk of malignant transformation. Our patient previously received a diagnosis of lichen sclerosus et atrophicus, suggesting a link between the two conditions.…”
Section: Case Discussionmentioning
confidence: 99%
“…Pseudoepitheliomatous, keratotic, and micaceous balanitis in fact can resemble both clinically and histologically genital hypertrophic lichen sclerosus et atrophicus [7]; both have a risk of malignant transformation. Our patient previously received a diagnosis of lichen sclerosus et atrophicus, suggesting a link between the two conditions.…”
Section: Case Discussionmentioning
confidence: 99%
“…68 Treatment is often variable, ranging from topical therapy with imiquimod, 5-fluoruracil, podophyllin, steroids to physical therapies such as cryotherapy or topical photodynamic therapy, electrocoagulation and/or CO 2 laser. 9,10 Advanced stages require wide margins surgery. 11…”
Section: Introductionmentioning
confidence: 99%
“…The duration of symptoms ranged from 2 months to 30 years, and 10 patients (41.6%) had a history of phimosis. [6][7][8][9]11,12,15,17,19,20 At the time of disease presentation, 19 patients (79.1%) were circumcised. Inguinal lymphadenopathy was not reported in the included patients.Histopathology of the lesion revealed hyperkeratosis and acanthosis in 14 patients.…”
mentioning
confidence: 99%
“…In symptomatic patients, itching, irritation, erythema, pain, soreness, pruritus, urinary symptoms, sexual symptoms and telangiectasia were reported. 1,2,[11][12][13][14][16][17][18][19] Urinary and sexual symptoms occurred in 16.6% (n = 4) and in 8.3% (n = 2) of the patients, respectively. The duration of symptoms ranged from 2 months to 30 years, and 10 patients (41.6%) had a history of phimosis.…”
mentioning
confidence: 99%
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