Pseudoepitheliomatous, keratotic, and micaceous balanitis mimicking lichen sclerosus et atrophicus

Tonin, Beatrice; Catenaro, Roberta; Girolomoni, Giampiero; Ghimenton, C; Gisondi, Paolo

doi:10.5070/d3269050171

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Pseudoepitheliomatous response to chronic inflammation has been proposed as a possible etiopathogenic mechanism. [ 4 ] Kang et al . reported a case of recurrent PKMB associated with human papillomavirus and postulated the role of transformation to verrucous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

A rare presentation of pseudoepitheliomatous keratotic and micaceous balanitis with malignant transformation

Nandakishore

Bhat

Fernandes

et al. 2022

Indian J Sex Transm Dis

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Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is a rare nonvenereal penile condition with a risk of malignant transformation. We report a case of PKMB in a 45-year-old male who presented with multiple keratotic growths over his glans penis after circumcision for long-standing phimosis. Histopathology revealed pseudoepitheliomatous hyperplasia and atypical cells. He was successfully treated with wide local excision.

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Section: Discussionmentioning

confidence: 99%

A rare presentation of pseudoepitheliomatous keratotic and micaceous balanitis with malignant transformation

Nandakishore

Bhat

Fernandes

et al. 2022

Indian J Sex Transm Dis

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“…Excision of localized disease proved effective for one of our patients; there are also nine cases of this previously described, with varying results. 6,7,[17][18][19]23,35,38,39 Other modalities published include partial penectomy (3 cases), [40][41][42] cryotherapy (3 cases), 10,17,27 radiotherapy (2 cases), 9,43 acitretin (2 cases) 24,26 and photodynamic therapy (1 case). 44…”

Section: Discussionmentioning

confidence: 99%

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases

Spencer

Watchorn

Kravvas

et al. 2022

Acad Dermatol Venereol

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Background Pseudoepitheliomatous keratotic and micaceous balanitis (PEKMB) is a clinicopathological entity characterized clinically by micaceous scale on the glans, and histologically by acanthosis, hyperkeratosis and pseudoepitheliomatous hyperplasia. We present a series of eight cases of this rare condition, the first series of more than two cases to be reported. Objectives To determine the clinical and histological characteristics of cases of PEKMB, and evaluate treatments used and clinical course. Methods This monocentric case series was conducted at the University College London Hospitals tertiary male genital dermatology clinic between April 2018 and August 2020. Eight patients with PEKMB were evaluated. Data were collected on demographics, clinical presentation, histological features, presence of human papilloma virus (HPV), history of lichen sclerosus, treatment of PEKMB and subsequent response, and presence or development of squamous cell carcinoma (SCC) or penile intraepithelial neoplasia (PeIN) during follow‐up. Results Eight Caucasian males presented with clinical and histological evidence of PEKMB. Seven had a background of lichen sclerosus; two had failed treatment with superpotent topical steroids and four had symptoms for three or more years prior to circumcision. There was no clinical or histological relationship with HPV infection, and p16 staining was negative. HPV PCR, performed in two cases, was negative. Basal atypia, insufficient to amount to PeIN, was present in six patients. One patient progressed to PeIN during follow‐up, and no patient progressed to invasive malignancy. Five patients were treated successfully with glans resurfacing and split skin graft reconstruction. Conclusions Our observations demonstrate that PEKMB represents a form of chronic, undiagnosed or misdiagnosed, inadequately treated or treatment refractory, unstable lichen sclerosus. The significant potential for squamous carcinogenesis (differentiated PeIN and verrucous carcinoma) can be mitigated by timely diagnosis and treatment. Glans resurfacing and split skin graft reconstruction appears to be a successful treatment modality in patients with refractory disease.

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Morphea and Extragenital Lichen Sclerosus Et Atrophicus Overlap

Dodeja,

Karani,

Pande

2024

Cureus

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Pseudoepitheliomatous, keratotic, and micaceous balanitis mimicking lichen sclerosus et atrophicus

Cited by 3 publications

References 8 publications

A rare presentation of pseudoepitheliomatous keratotic and micaceous balanitis with malignant transformation

A rare presentation of pseudoepitheliomatous keratotic and micaceous balanitis with malignant transformation

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases

Morphea and Extragenital Lichen Sclerosus Et Atrophicus Overlap

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