Pseudo surface acoustic wave dual delay line on 41°YX LiNbO3 for liquid sensors

205

113

This review presents a deep insight into the Surface Generated Acoustic Wave (SGAW) technology for biosensing applications, based on more than 40 years of technological and scientific developments. In the last 20 years, SGAWs have been attracting the attention of the biochemical scientific community, due to the fact that some of these devices - Shear Horizontal Surface Acoustic Wave (SH-SAW), Surface Transverse Wave (STW), Love Wave (LW), Flexural Plate Wave (FPW), Shear Horizontal Acoustic Plate Mode (SH-APM) and Layered Guided Acoustic Plate Mode (LG-APM) - have demonstrated a high sensitivity in the detection of biorelevant molecules in liquid media. In addition, complementary efforts to improve the sensing films have been done during these years. All these developments have been made with the aim of achieving, in a future, a highly sensitive, low cost, small size, multi-channel, portable, reliable and commercially established SGAW biosensor. A setup with these features could significantly contribute to future developments in the health, food and environmental industries. The second purpose of this work is to describe the state-of-the-art of SGAW biosensors for the detection of pathogens, being this topic an issue of extremely importance for the human health. Finally, the review discuses the commercial availability, trends and future challenges of the SGAW biosensors for such applications.

Section: Sgaw Devices For Biosensingmentioning

confidence: 99%

Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review

Rocha-Gaso

March-Iborra

Montoya-Baides

et al. 2009

205

113

“…The parameter that determines the resonance frequency of this device is the IDT spacing and its typical operating frequency is 30–500 MHz. The most commonly used substrate for this device is 36° YX LiTaO 3 , but ST- quartz [15,51], 41° YX LiNbO 3 [52,53], 64° YX LiNbO 3 [54–56], potassium niobate (KNbO 3 ) [57] and Langasite (LGS) [28,58] have also been utilized.…”

Section: Sgaw Devices For Biosensingmentioning

confidence: 99%

Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review

Rocha-Gaso

March-Iborra

Montoya-Baides

et al. 2009

This review presents a deep insight into the Surface Generated Acoustic Wave (SGAW) technology for biosensing applications, based on more than 40 years of technological and scientific developments. In the last 20 years, SGAWs have been attracting the attention of the biochemical scientific community, due to the fact that some of these devices -Shear Horizontal Surface Acoustic Wave (SH-SAW), Surface Transverse Wave (STW), Love Wave (LW), Flexural Plate Wave (FPW), Shear Horizontal Acoustic Plate Mode (SH-APM) and Layered Guided Acoustic Plate Mode (LG-APM) -have demonstrated a high sensitivity in the detection of biorelevant molecules in liquid media. In addition, complementary efforts to improve the sensing films have been done during these years. All these developments have been made with the aim of achieving, in a future, a highly sensitive, low cost, small size, multi-channel, portable, reliable and commercially established SGAW biosensor. A setup with these features could significantly contribute to future developments in the health, food and environmental industries. The second purpose of this work is to describe the state-of-the-art of SGAW biosensors for the detection of pathogens, being this topic an issue of extremely importance for the human health. Finally, the review discuses the commercial availability, trends and future challenges of the SGAW biosensors for such applications.

“…These SH-SAW biosensors are largely categorized into four general groups depending on their configurations: (1) a two-port delay line biosensor; (2) a one-port reflective delay line biosensor for wireless and battery-free measurements; (3) a resonator-type biosensor; and (4) a Love wave biosensor employing a waveguide layer (overlayer) on the top of the surface acoustic wave (SAW)-delay line. Of these biosensor configurations, the most widely used type is the two-port delay line biosensor, in which one delay line is coated with a sensitive film, while the other is left uncoated for use as a reference delay line [ 15 – 17 ]. The adsorption of a target biomolecule onto the sensitive film changes the velocity of the SH acoustic wave passing through the underneath of the sensitive film using various mechanisms such as the mass loading effect, viscoelastic effect and electro-conductivity effect, resulting in a frequency shift at the output of the SAW device.…”

Section: Introductionmentioning

confidence: 99%

Wireless and Simultaneous Detections of Multiple Bio-Molecules in a Single Sensor Using Love Wave Biosensor

Kim

et al. 2014

A Love wave-based biosensor with a 440 MHz center frequency was developed for the simultaneous detection of two different analytes of Cartilage Oligomeric Matrix Protein (COMP) and rabbit immunoglobulin G (IgG) in a single sensor. The developed biosensor consists of one-port surface acoustic wave (SAW) reflective delay lines on a 41° YX LiNbO3 piezoelectric substrate, a poly(methyl methacrylate) (PMMA) waveguide layer, and two different sensitive films. The Love wave biosensor was wirelessly characterized using two antennas and a network analyzer. The binding of the analytes to the sensitive layers induced a large change in the time positions of the original reflection peaks mainly due to the mass loading effect. The assessed time shifts in the reflection peaks were matched well with the predicted values from coupling of mode (COM) modeling. The sensitivities evaluated from the sensitive films were ∼15 deg/μg/mL for the rabbit IgG and ∼1.8 deg/ng/mL for COMP.