Pseudo-Pelger-Leukoeyten bei experimenteller Ratten-Leukämie

Transmission of a Filterable Agent from Rat Leukaemia Induced by X-Ray Irradiation and Treatment with Methylcholanthrene

“…In previous papers (9,10,24) we have shown that the solid BS-carcinoma, maintained by transplantation in Wistar rats of our colony, contains a submicroscopic agent which induces myelo genous leukaemia after a latency period of 5 to 15 months. In this paper we are reporting about the transmission by cell-free filtrates of myelogenous leukaemia induced by X-irradiation and methylcholanthrene.…”

“…This agent, probably a virus, can be activated by X-irradiation or by chemical carcinogens. On the other hand, many experimental findings suggest that oncogenic viruses may be of endogenic origin (2,5,9,17). They may arise from the cytoplasmatic organes, such as the endoplasmic reticulum, in consequence of their mutational changes (1,3).…”

“…In 1955 we succeeded, for the first time, in inducing myelo genous leukaemia in random-bred Wistar rats by cell-free filtrates from BS-carcinoma (9,22,24). This leukaemia is transplantable.…”

“…From 59 treated rats, lymphatic leukaemia developed in 6 and myelo genous in 2 rats. In our laboratory leukaemia was induced by combination of X-irradiation and peroral application of mcthylcholanthrenc in about 5% of animals (9). The rats were irradiated by a single dose of 800 r. Methylcholanthrene was applied three times a week by a stomach tube in a dose of 1 mg for 9 months.…”

Pelger-Huët Anomaly in Lymphocytic Leukaemia

“…In addition, Pf.lger cells have been produced with colchicine (15) and pyripher (16). They have also been found in experimental leukaemia in animals (17).…”