Acquired Pseudo-Pelger Anomaly of Granulocytic Leukocytes

Pelger-Huët Anomaly in Lymphocytic Leukaemia

“…The P e l g e r -H u ët anomaly of leukocytes has been reported in the literature in connection with various diseases such as chronic myelocytic leukaemia (3,8,9,10,11), acute myeloid leukaemia (11,12) myeloid metaplasia (12), polycythaemia (12,13), agra nulocytosis (5, 9), thrombopenic purpura (9), plasmocytoma (14) and enterocolitis (6). The combined occurrence of lymphocytic leukaemia and Pelger-Huet anomaly in the same patient is only mentioned briefly by Undritz (7), who says that Verloop had come across one such case.…”

“…Several authors, for instance, emphasise that pseudo-PELGER cells are often encountered in connection with myelocytic leukaemia in particular (3,5,14). The nuclear anomaly seems also to be reversible since the disappearance of anomalous cells coincided with a remission of the acute leukaemic process in at least one case re ported by Dorr and Moloney (12). In addition, Pf.lger cells have been produced with colchicine (15) and pyripher (16).…”

Promyelocytic Leukaemoid Reaction: An Atypical Presentation of Mycobacterial Infection

“…One of these was Pelger-Huet nuclear anomaly [8], and the other was the abnormal peroxi dase-positive primary granules characteristic of Chediak-Steinbrink-Higashi syndrome [9], The former morphological abnormality is usually seen in myelo proliferative and preleukaemic disorders [11,12], Ca meron [3] has reported a case of tuberculosis pre senting as myelomonocytic leukaemia which showed a favourable response to antituberculous chemother apy. Albeit various mechanisms have been postulated to explain the blood dyscrasias in tuberculosis [3,13], the current view favours the immunological alteration of the body by disseminated tuberculosis [3,13].…”

Preleukaemia

“…This is a heritable disorder but can be acquired secondary to other disorders particularly acute myeloid leukaemia (8 ) . D a r t e et al (7) demonstrated that in a case of acquired Pelger Huet anomaly secondary to myeloid leukaemia the proportion of anomalous cells increased as the disease progressed and this pattern was repeated here.…”