Pseudo-Achromia of Tinea Versicolor

Lewis, George M.

doi:10.1001/archderm.1936.01470170098008

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…2 Pityriasis versicolor may appear as the so-called alba form, which is characterised by depigmented areas on which sunburn can hardly be provoked. 3 The potent UV-filtering compound pityriacitrin, produced by Malassezia furfur as previously described by us, might explain this phenomenon. 4 The growth of Malassezia furfur is known to be inhibited by UV light 5 and this yeast is most sensitive among microorganisms that occur commonly on human skin, such as Candida albicans, Staphylococcus aureus and Staphylococcus epidermidis.…”

Section: Introductionmentioning

confidence: 53%

“…These yeast are also associated with pityriasis versicolor, a common skin disease especially in tropical regions 2 . Pityriasis versicolor may appear as the so‐called alba form, which is characterised by depigmented areas on which sunburn can hardly be provoked 3 . The potent UV‐filtering compound pityriacitrin, produced by Malassezia furfur as previously described by us, might explain this phenomenon 4…”

Section: Introductionmentioning

confidence: 76%

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Pityriacitrin – a potent UV filter produced by Malassezia furfur and its effect on human skin microflora

Machowinski

Krämer

Hort

et al. 2006

Mycoses

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In Malassezia furfur, tryptophan as the main nitrogen source induces production of the potent ultraviolet-absorbing indole compound pityriacitrin. An in vitro study about the effects of pityriacitrin on other human skin microorganisms is presented, with special focus on Candida albicans and staphylococci in which its toxicity and UV-protective capacity were investigated. Candida albicans was irradiated with UVB light either in the presence or in the absence of pityriacitrin (11 mmol) and the growth rate was determined. A UVB dose of 1 J cm(-2) caused death of the fungi without pityriacitrin, whereas those in the presence of pityriacitrin showed almost unaffected growth. A diffusion test in staphylococci revealed no antibiotic effects of pityriacitrin. For testing of an ultraviolet-protective effect, staphylococci were either inoculated and irradiated in a plate model for visual assessment of growth or inoculated and irradiated in square quartz cylinders for quantitative measurement of cell density, each time in the absence or presence of pityriacitrin. Cell density of the bacterial suspensions exhibited nearly no influence of pityriacitrin on growth rates, while again a UV-protective effect was observed. In summary, pityriacitrin has an ultraviolet-protective effect on Candida albicans and staphylococci with no toxicity in the range tested.

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Section: Introductionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 76%

Pityriacitrin – a potent UV filter produced by Malassezia furfur and its effect on human skin microflora

Machowinski

Krämer

Hort

et al. 2006

Mycoses

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“…32 It is not regularly developed in depigmented areas of PVa. While depigmentation with scaling has been reported, 25,33 depigmented areas without any desquamation 23 represent problems in the differential diagnosis of PVa with other depigmenting diseases, particularly with vitiligo. 16 In the older literature time course dependent presence of scaling is described.…”

Section: Clinic Of Pityriasis Versicolor Albamentioning

confidence: 99%

“…There is no description of pigment incontinence so depigmentation does not result from destruction of melanocytes. The DOPA reaction in skin specimens of depigmented lesions is predominantly positive 16,28,33 . Ruete is the only author describing a completely negative DOPA reaction in the depigmented area, which, however, was demonstrated in only one skin sample 20…”

Section: Histology and Electron Microscopy Of Pityriasis Versicolor Albamentioning

confidence: 99%

“…The DOPA reaction in skin specimens of depigmented lesions is predominantly positive. 16,28,33 Ruete is the only author describing a completely negative DOPA reaction in the depigmented area, which, however, was demonstrated in only one skin sample. 20 Light microscopy of depigmented PVa as well as of hyperpigmented areas of PV reveals lower pigment density within the melanocytes in the DOPA reaction and Fontana-Masson stain compared with normal skin of the same individual.…”

Section: Histology and Electron Microscopy Of Pityriasis Versicolor Albamentioning

confidence: 99%

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Pityriasis versicolor alba

Thoma¹,

Hj²,

Mayser³

2005

Acad Dermatol Venereol

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Pityriasis versicolor alba is a hypopigmented or depigmented variant of pityriasis versicolor characterized by maculous, partly pityriasiform, scaly depigmented lesions occurring particularly in seborrhoeic areas. Long-persisting hypopigmentation after healing of the pityriasis versicolor was first described by Gudden in 1853. Hypopigmentation and depigmentation were later differentiated as an independent variant of the disease. In 1848, Eichstedt recognized the pathogen-related character of pityriasis versicolor in its hyperpigmented form. Today it is generally accepted that the disease is caused by yeasts of the genus Malassezia, of which nine species are differentiated. It is controversial whether a single species is responsible for the disease. The pathogenesis of depigmentation has not been established. A screening effect by the scale layer as well as toxic effects on pigment synthesis by fungal metabolites have been discussed. With regard to the second mechanism, the newly discovered tryptophan-derived metabolites of M. furfur might be significant. Evidence-based data concerning the therapy of pityriasis versicolor alba do not exist. According to current recommendations, pityriasis versicolor should be rapidly treated with antimycotics, followed by ultraviolet therapy to induce maturation of existent melanosomes and accelerate repigmentation. However, depigmented lesions are difficult to improve by ultraviolet therapy.

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Fluorescent Material in Scales, Nails, and Hair

Lèvit¹

1959

Arch Dermatol

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Pseudo-Achromia of Tinea Versicolor

Cited by 10 publications

References 3 publications

Pityriacitrin – a potent UV filter produced by Malassezia furfur and its effect on human skin microflora

Pityriacitrin – a potent UV filter produced by Malassezia furfur and its effect on human skin microflora

Pityriasis versicolor alba

Fluorescent Material in Scales, Nails, and Hair

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