Psammomatoid juvenile ossifying fibroma of the jaws

Abstract

Juvenile ossifying fibroma is an uncommon, benign, bone-forming neoplasm with aggressive local growth that is distinguished from other fibro-osseous lesions primarily by its age of onset, clinical presentation and aggressive behavior. Although a benign entity, juvenile ossifying fibroma is known to be locally aggressive and has a high tendency to recur. Two distinctive microscopic patterns have been described: A trabecular variant and a psammomatoid variant. This latter variant is predominantly a craniofacial lesion and occurs rarely in the jaws. We present herein two cases of psammomatoid juvenile ossifying fibroma involving the jaws. The first case was a mandibular lesion in a 31-year-old female whereas the second case presented with maxillary involvement in a 46-year-old female. In addition, the pathology of the lesion was analyzed with confocal laser scanning microscopy.

Le fibrome ossifiant juvénile : 2 cas et revue de littérature

“…Le rythme de croissance de la tumeur diffère selon sa localisation et son agressivité. Son augmentation de volume peut être à l'origine de paresthésie, malocclusion, sinusite ou proptosis [12,13]. De façon générale, le FOJ est une tumeur très agressive et de croissance rapide comparée à d'autres lésions fibro-osseuses des maxillaires.…”

“…La tumeur peut entraîner une expansion ou une rupture des corticales, un déplacement voire une résorption des racines [2,13]. Le fibrome ossifiant est caractérisé par un aspect en « verre dépoli », non encapsulé, séparé de l'os environnant par une frontière radio-opaque [12,14]. Cet aspect peut aider à le différencier de la dysplasie fibreuse qui est caractérisée par une image radiographique sans limite nette [15].…”

A Novel Treatment of Aggressive Psammomatoid Juvenile Ossifying Fibroma: A Case Report

“…Approximately, 75% of PsJOFs develop in the orbit, paranasal sinuses, and calvaria, whereas only about 25% of all cases involve the maxilla or mandible (8). The first clinical manifestation is a swelling of the maxilla.…”

“…Johnson et al have reported JOFs occurring at any age between 3 months and 72 years (4). These lesions are unique because of their aggressive behavior mimicking malignancy (8), so needs to be distinguished from malignant bone tumors because there is a similarity of clinical manifestations, but JOF can be easily excluded from malignant bone tumors on the routine histological examination (9).…”

Juvenile Psammomatoid Ossifying Fibroma of Maxillary Sinus: Case Report with Review of Literature

“…The spectrum of fibro-osseous lesions includes a variety of developmental, reactive or dysplastic lesions and neoplastic entities [4]. According to WHO classification in 2005, benign fibro-osseous lesions in the oral and maxillofacial regions were divided into two categories, osteogenic neoplasms and non-neoplastic bone lesions; cemento-ossifying fibroma was included into the former category [5].…”