Psammoma bodies and thyroid cancer

Klinck, G. H.; Winship, Theodore

doi:10.1002/1097-0142(195907/08)12:4<656::aid-cncr2820120406>3.0.co;2-#

Cited by 96 publications

(40 citation statements)

References 3 publications

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“…greater in its antero posterior dimension than its transverse dimension) has 93% specificity for malignancy. 15 This appearance is thought to be due to a centrifugal tendency in tumor growth, which does not necessarily occur at a uniform rate in all dimensions. In this study it is found that 77.27% of cases showing this feature.…”

Section: Shapesupporting

confidence: 89%

“…Their occurrence has been described in follicular and anaplastic thyroid carcinomas as well as in benign conditions such as follicular adenoma and Hashimoto thyroiditis. 10,[14][15][16][17] At US, micro calcifications appear as punctate hyper echoic foci without acoustic shadowing. In this study micro calcifications are found in 45.5% of malignant cases and only in one benign case…”

Section: Calcificationsmentioning

confidence: 99%

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Predictors of malignancy in solitary nodule thyroid

2017

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INTRODUCTIONSolitary thyroid nodule (SNT) is a common thyroid disorder, clinically palpable nodules are encountered in about 8% of the adult population and the incidence of malignancy in SNT is very high compared to other thyroid swelling. The risk of malignancy in SNT is 15% compred to 3% in multinodular goiter. With the use of ultrasound, the chance of detection of thyroid nodules has increased considerably.

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Section: Shapesupporting

confidence: 89%

Section: Calcificationsmentioning

confidence: 99%

Predictors of malignancy in solitary nodule thyroid

2017

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“…As for the diagnostic significance of various patterns of thyroid calcification, the current study has led us to the same conclusion as that stated by previous investigators (Klinck and Winship, 1959;Batsakis et al, 1960;Hisada et al, 1962;Onishi, 1966;Hoshi et al, 1967;Margolin et al, 1967). Namely, only the presence of psammoma bodies has a diagnostic value and they are almost pathognomonic to the thyroid carcinoma.…”

Section: Discussionsupporting

confidence: 85%

Roentgenographic-Histologic Patterns of Calcification in Thyroid Nodules

Fujimoto

Akisada

1970

Endocrinol Japon

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Synopsis Roentgenographicand histologic examinations were carried out on excised specimens of 100 cases of malignant thyroid neoplasms and of 98 cases of benign nodules. Industrial film and low voltage were used to obtain the maximum detail. Microscopic sections stained with hematoxylin and eosin were examined in all the cases and the selected 24 sections were stained by von Kossa's method. Calcium deposits were grossly classified into psammomatous and coarse types. The former was seen in 59 of 100 malignant tumors and in only 2 of 98 benign nodules, whereas the latter was observed equally in both the malignant and benign nodules at the rate of 42%. Roentgenographic-histologic study revealed that most of the psammomatous calcifications were produced by true psammoma bodies, but there were a few exceptions, which were minute calcific deposits in the fibrous stroma and, in the cases of the medullary carcinoma, were calcifications in the amyloid. Several modes of development and distribution of psammoma bodies were found and each example was shown. Coarse calcifications were present in areas of fibrosis and showed various configurations. In only 2 adenomas, calcific deposits were seen along the sinusoidal vascular structures within the tumor parenchyma and fleece-like shadows were obtained on x-ray films. Other types of coarse calcification have no relationship to histologic diagnosis.

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“…Microcalcifications correspond pathologically to calcified psammoma bodies that are typical of papillary cancer (Meissner et al, 1958;Klinck et al, 1959;Pusztaszeri et al, 2013). Macro calcification or coarse calcifications are related to fibrosis and degeneration (Wang et al, 2006).…”

Section: Discussionmentioning

confidence: 99%