Predictors of malignancy in solitary nodule thyroid

Paul, Prasad; Ali, Karatparambil Abid; Jasir, Mohammed

doi:10.18203/2349-2902.isj20170217

Cited by 5 publications

(10 citation statements)

References 11 publications

(20 reference statements)

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“…In agreement with our study, Paul et al reported that the incidence of malignancy is higher in men [12]. Moreover, Li et al reported that the incidence of thyroid cancer in male patients was significantly higher than in female patients (p=0.003) [13].…”

Section: Discussionsupporting

confidence: 93%

Thyroid Nodule Size and Prediction of Cancer: A Study at Tertiary Care Hospital in Saudi Arabia

Al‐Hakami¹,

Alqahtani²,

Alahmadi³

et al. 2020

Cureus

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Background Thyroid nodules have become relatively common in clinical practice, and their prevalence increases with age. The majority of thyroid nodules are benign, with 5-15% being malignant. There are a number of well-established predictors of malignancy in thyroid nodules, but thyroid nodule size has been a cause for concern for many researchers and results of the studies are still controversial about their probability of malignancy. Up to the current knowledge, there is no published study that evaluates if thyroid nodule size is associated with the risk of malignancy in Saudi Arabia, so in this study, we aim to find that. Methods This is a retrospective study of 987 patients who underwent thyroid nodule fine-needle aspiration (FNA) and subsequent thyroidectomy for thyroid nodules measuring ≥ 1 cm. Results Thyroid cancer was more prevalent in males than females, and in patients who were older than or equal to 45 years. Nodular size of 1-1.9 cm was more prevalent among cancer patients than in benign cases (p<0.001). Conclusions The highest malignancy risk was observed in nodules <2 cm and no increase in malignancy risk for nodules >2 cm. Nevertheless, when examined by type of thyroid malignancy, the rate of follicular carcinoma and other rare malignancy increased with increasing nodule size.

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Section: Discussionsupporting

confidence: 93%

Thyroid Nodule Size and Prediction of Cancer: A Study at Tertiary Care Hospital in Saudi Arabia

Al‐Hakami¹,

Alqahtani²,

Alahmadi³

et al. 2020

Cureus

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“…Regarding TSH levels there was no significant difference between benign and malignant nodules (p=0.722). There are statistically significant ultrasound data shown in (table 3) 16 .…”

Section: Discussionmentioning

confidence: 87%

“…A recent study reported similar data with high incidence of malignancy in males 1 9. On the other hand, Paul et al (2017) reported that incidence of malignancy is higher in females 16 . Other studies reported that there is no significant difference between both sexes regarding the incidence of malignancy 18,20,21 .…”

Section: Outmentioning

confidence: 99%

“…Out of 30 cases with malignant thyroid nodules there were 25 cases with hypoechoic pattern (p=0.004). Paul et al (2017), reported that hypo-echoic nodules were seen in 82% of malignant cases 16 . Other studies reported similar data 8.24 .…”

Section: Outmentioning

confidence: 99%

“…reported that enlargement of lymph nodes are of low value in predicting malignancy in thyroid nodules 16 .…”

Section: Outmentioning

confidence: 99%

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Predictors of Malignancy in Patients With Thyroid Nodule(s)

Alatiar

Elfol²,

Rageh³

2017

J Surg Cl Res

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Purpose: To detect the predictors of malignancy in patients with thyroid nodule(s). Background: Thyroid nodules are common surgical problem with 5-10% risk of malignancy. Thyroid surgery is a major operation with many complications. So, it is important to search for the predictors of malignancy in thyroid nodules to spare more benign lesions from surgery. Patients and methods: This prospective study includes 150 patients with thyroid nodule(s), all were admitted for thyroidectomy at Menoufia University Hospital. Demographic and clinical data, ultrasound, fine needle aspiration reports and final histopathology were recorded and analyzed. Patients with previous thyroid surgery or previous neck biopsy were excluded. Results: About 20% of the studied population proved to have malignant nodules on final histopathology reports. Out of 150 cases, there were 83 with multi-nodular goiter and 67 with solitary thyroid nodules. There were higher incidence of malignancy in male patients. The incidence also was higher in solitary nodules than in multinodular goiter. There were statistically significant ultrasound features differences such as; micro-calcifications, ill-defined edges, solid consistency, hypo-echoic pattern, intra-nodular vascularity and size below 2cm. Regarding fine needle biopsy, there were a significant increase in incidence of malignancy from Bethesda(II) – Bethesda(VI) with highest incidence in Bethesda(VI). Conclusion: Predictors of malignancy detected were; male gender, solitary nodules, micro-calcifications, hypo-echoic pattern, ill-defined edges, intra-nodular vascularity, solid nodules, size below 2 cm and Bethesda VI. Large scale multi center studies are needed for more solid statistical result.

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Predictors of Malignancy in Thyroid Nodules

Ragab

Sayouh

Sarhan

2021

International Journal of Medical Arts

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Background: Better and early prediction of malignant thyroid nodule, and sure differentiation from benign one, is crucial need to decrease the rate of non-indicated surgeries. The aim ofthe work: To find risk factors and predictors of malignancy in patients with thyroid nodule[s]. Patients and Methods: Fifty patients with thyroid nodule[s] were included. All patients were evaluated by history taking, clinical examination and laboratory investigations. Imaging studies included thyroid ultrasound [US]. All were also submitted to fine needle aspiration cytology [FNAC] before treatment by total or subtotal thyroidectomy.Excised tissues were sent to histopathological analysis. Results:The incidence of malignancy was 22.0%. both benign and malignant groups were comparable as patient characteristics, complaints except the significant increase in cosmetic disfigurement among patients with benign nodules [92.3% vs. 45.5%]. Patients with malignant nodules had a significant increase of ill-defined margins, intranodular vascularity and enlarged lymph nodes [72.7%, 63.6% and 72.7% vs 5.1%, 12.8% and 25.6% respectively]. Ill-defined margins, enlarged lymph node and high grade in FNAC were the predictors of thyroid malignancy. Conclusion:Predictors of malignant thyroid nodules are ill-defined edges, enlarged lymph node and high grade in FNAC. This helps clinicians to spare more benign cases from surgical interference.

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Predictors of malignancy in solitary nodule thyroid

Cited by 5 publications

References 11 publications

Thyroid Nodule Size and Prediction of Cancer: A Study at Tertiary Care Hospital in Saudi Arabia

Thyroid Nodule Size and Prediction of Cancer: A Study at Tertiary Care Hospital in Saudi Arabia

Predictors of Malignancy in Patients With Thyroid Nodule(s)

Predictors of Malignancy in Thyroid Nodules

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