PS-TBD triggered general protocol for the synthesis of 4 H -chromene, pyrano[4,3- b ]pyran and pyrano[3,2- c ]chromene derivatives of 1 H -pyrazole and their biological activities

Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines

“…[5][6][7] Fused pyran derivatives have emerged as promising candidates in cancer therapeutics due to their ability to target the cellular pathways, resulting in the inhibition of cancer cell growth, induction of apoptosis, and disruption of essential cellular processes that are crucial for tumor progression. [8][9][10][11][12][13][14][15][16][17][18][19][20] These moieties have also been reported to exhibit a wide array of pharmacological activities that include antimicrobial, [21][22][23][24][25][26][27] antitubercular, 21 antioxidant, 24,28 analgesic, 25 antileishmanial, 29 antiplatelet, 30 formyl peptide receptor 1 (FPR1) antagonist, 31 and anticonvulsant activities. 32 In addition, they were also identified as potent selective estrogen receptor modulators (SERMs), 33 inhibitors of enzymes such as acetylcholinesterase, 28 monoamine oxidase, 34,35 topoisomerase 2, 36 c-Src kinase, 37 xanthine oxidase, 38 and aldehyde reductase 2 (ALR2).…”

One‐pot green synthesis, study of fluorescence properties, and biological activity of pyrano[3,2‐c]chromenes derivatives via mesoporous materials MgO/SBA‐15

“…In the literature, many works have been approved, and prepared heterogeneous catalysts are used for the synthesis of pyrano-[3,2-c]chromenes under heating and in the presence of solvents notably: rare earth perfluorooctanoates [RE(PFO) 3 ] [31], MgO nanoparticle [32], High Surface Area MgO [33], H 14 [NaP 5 W 30 O 110 ], H 6 P 2 W 18 O 62 ‧ 18H 2 O [34], Nano aluminum oxide, Nano aluminum hydroxide [35], nanostructured diphosphate Na 2 CaP 2 O 7 [36], α-Fe 2 O 3 nanoparticles [37], sulfonic acid functionalized silica (SiO 2 PrSO 3 H) [38], silica-bonded N-propylpiperazine sodium n-propionate (SBPPSP) [39], magnetic catalytic system ([γ-Fe 2 O 3 @Hap-Si-(CH 2 ) 3 -AMP] [40], polymer supported sulfanilic acid [41], ZnAl 2 O 4 -Bi 2 O 3 composite nanopowder [42], Fe 3 O 4 @SiO 2imid-PMAn nanoparticles [43], CuO nanoparticles [44,45], Bi 2 O 3 nanoparticles [46], ZnO nano-particles [47], polystyrene supported 7-methyl-1,5,7-triazabicyclo [4.4.0]dec-5-ene PS-TBD [48], nano-SiO 2 [49], dehydroabietylamine-cinchonine-squaramide [50], Zn 2 SnO 4 nanoparticles [51], Zn 3 (PO 4 ) 2 ‧4H 2 O [52].…”

Design, Synthesis, Biological Evaluation, and Molecular Modeling of Novel 4H-Chromene Analogs as Potential Succinate Dehydrogenase Inhibitors

“…Chromene scaffolds exist in molecular structures of various natural products, such as flavones and coumarins. Chromene derivatives have divergent biological activities, including inhibitory activities against pathogenic fungi, such as Fusarium oxysporrm, Geotricum candidum, , Trichophyton rubrum, , Aspergillus fumigatus, , Aspergillus flavus, , Candida albicans, − and Aspergillus niger (Figure S2). ,, Therefore, chromene derivatives play an important part in the research and development of bioactive compounds, natural products, and synthetic drugs.…”