Prussian blue nanoparticles: Synthesis, surface modification, and application in cancer treatment

Gautam, Milan; Poudel, Kishwor; Yong, Chul Soon; Kim, Jong Oh

doi:10.1016/j.ijpharm.2018.07.055

Cited by 88 publications

(70 citation statements)

References 178 publications

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“…The necessary features for preclinical trials of nanodrugs include controlled preparation at the gram level and good dispersion stability under physiological conditions. Various PB nanoparticles with different structures have been prepared, and these have exhibited good dispersion stability under physiological conditions 34 . However, the controlled mass production of PB nanoparticles even at the gram level remains a challenge.…”

Section: Resultsmentioning

confidence: 99%

Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway

Xie¹,

Zhao²,

Gao³

et al. 2021

Theranostics

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Rationale: Acute pancreatitis (AP) is a serious acute condition affecting the abdomen and shows high morbidity and mortality rates. Its global incidence has increased in recent years. Inflammation and oxidative stress are potential therapeutic targets for AP. This study was conducted to investigate the intrinsic anti-oxidative and anti-inflammatory effects of Prussian blue nanozyme (PBzyme) on AP, along with its underlying mechanism. Methods: Prussian blue nanozymes were prepared by polyvinylpyrrolidone modification method. The effect of PBzyme on inhibiting inflammation and scavenging reactive oxygen species was verified at the cellular level. The efficacy and mechanism of PBzyme for prophylactically treating AP were evaluated using the following methods: serum testing in vivo , histological scoring following hematoxylin and eosin staining, terminal deoxynucleotidyl transferase dUTP nick end labeling fluorescence staining, polymerase chain reaction array, Kyoto Encyclopedia of Genes and Genomes analysis and Western blotting analysis. Results: The synthetic PBzyme showed potent anti-oxidative and anti-inflammatory effects in reducing oxidative stress and alleviating inflammation both in vitro and in vivo in the prophylactic treatment of AP. The prophylactic therapeutic efficacy of PBzyme on AP may involve inhibition of the toll-like receptor/nuclear factor-κB signaling pathway and reactive oxygen species scavenging. Conclusion: The single-component, gram-level mass production, stable intrinsic biological activity, biosafety, and good therapeutic efficacy suggest the potential of PBzyme in the preventive treatment of AP. This study provides a foundation for the clinical application of PBzyme.

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Section: Resultsmentioning

confidence: 99%

Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway

Xie¹,

Zhao²,

Gao³

et al. 2021

Theranostics

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“…The representative reaction scheme is presented in Figure . It is reported that presence of excess amount of FeCl 3 favors the precipitation of the crystalline Prussian blue, whereas equivalent amount favors the formation of water soluble material. In the present study, we were not interested in the precipitation of neat Prussian blue, where counter ion will be Fe(II)/Fe(III) .…”

Section: Resultsmentioning

confidence: 99%

“…It is reported that presence of excess amount of FeCl 3 favors the precipitation of the crystalline Prussian blue, whereas equivalent amount favors the formation of water soluble material. In the present study, we were not interested in the precipitation of neat Prussian blue, where counter ion will be Fe(II)/Fe(III) . Instead, we were interested to make a Prussian blue with proton as counter ion, which can protonate EPANI to enhance its electrochemical performance in EOP application.…”

Section: Resultsmentioning

confidence: 99%

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A non‐gassing electroosmotic pump with sandwich of poly(2‐ethyl aniline)‐Prussian blue nanocomposite and PVDF membrane

et al. 2019

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Low voltage, non‐gassing electroosmotic pump (EOP) was assembled with poly(2‐ethyl aniline) (EPANI)‐Prussian blue nanocomposite electrode and commercially available hydrophilic PVDF membranes. The nanocomposite material combines excellent oxidation/reduction capacity of EPANI with exceptional stability by shuttling of proton between Prussian blue nanoparticles and EPANI redox matrix. The flow rate was highly dependent on the electrode composition but it was linear with applied voltage. The flow rate at 5 V for different nanocomposite, EPANI, EPANI‐A, EPANI‐B, and EPANI‐C were 127.29, 187.41, 148.51, and 95.47 µL/min cm2, respectively, which increases substantially with increase in the Prussian blue content. The obtained best electro osmotic flux was 43 µL/min/V/cm2 for EPANI‐A. It was higher than most of the EOP assembled using polyquinone and polyanthraquinone redox polymers. The assembled EOP remained exceptionally stable until the electrode charge capacity was fully utilized. The best EOP produces a maximum stall pressure of 1.2 kPa at 2 V. These characteristics make it suitable for a variety of microfluidic/device applications.

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“…The conditions of PB preparation and their sorption capacity are shown in Table 1. An excess of FeCl 3 was applied to ensure the insoluble PB's precipitation [33]. We started with a 1:1.15 molar ratio, but during the washing most of the precipitate dissolved.…”

Section: Prussian Blue Preparation and Characterizationmentioning

confidence: 99%

Hybrid Pectin-Based Sorbents for Cesium Ion Removal

et al. 2020

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In this paper, beads-shaped hybrid sorbents composed of pectin and Prussian blue were prepared. Various ratios of pectin and Prussian blue in hybrid sorbents were tested. Obtained sorbents had high and roughly constant sorption capacity in a broad pH range (4–10), in which also the swelling index and stability of sorbents were satisfactory. The preliminary sorption studies proved that almost 100% of cesium removal efficiency may be achieved by using the proper sorbent dose. The sorption capacity of the hybrid sorbent with a 1:1 ratio of pectin to Prussian blue equaled q = 36.5 ± 0.8 mg/g (dose 3 g/L, pH = 6, temp. = 22 ± 1 °C, t = 24 h). The obtained results showed that the prepared hybrid pectin-based sorbents are promising for cesium ions removal.

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Prussian blue nanoparticles: Synthesis, surface modification, and application in cancer treatment

Cited by 88 publications

References 178 publications

Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway

Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway

A non‐gassing electroosmotic pump with sandwich of poly(2‐ethyl aniline)‐Prussian blue nanocomposite and PVDF membrane

Hybrid Pectin-Based Sorbents for Cesium Ion Removal

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