Prussian Blue (bio)sensing device for distance-based measurements

Granica, Mateusz; Tymecki, Łukasz

doi:10.1016/j.aca.2020.08.037

Cited by 11 publications

(5 citation statements)

References 40 publications

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“…Besides chloride, other sweat biomarkers such as glucose and ascorbic acid [ 36 ] can also be detected. For instance, glucose detection is achieved using the Prussian white (PW)/Prussian blue (PB) system.…”

Section: Resultsmentioning

confidence: 99%

Skin‐Interfaced Bifluidic Paper‐Based Device for Quantitative Sweat Analysis

Deng,

Li,

Song

et al. 2023

Advanced Science

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The erratic, intermittent, and unpredictable nature of sweat production, resulting from physiological or psychological fluctuations, poses intricacies to consistently and accurately sample and evaluate sweat biomarkers. Skin‐interfaced microfluidic devices that rely on colorimetric mechanisms for semi‐quantitative detection are particularly susceptible to these inaccuracies due to variations in sweat secretion rate or instantaneous volume. This work introduces a skin‐interfaced colorimetric bifluidic sweat device with two synchronous channels to quantify sweat rate and biomarkers in real‐time, even during uncertain sweat activities. In the proposed bifluidic‐distance metric approach, with one channel to measure sweat rate and quantify collected sweat volume, the other channel can provide an accurate analysis of the biomarkers based on the collected sweat volume. The closed channel design also reduces evaporation and resists contamination from the external environment. The feasibility of the device is highlighted in a proof‐of‐the‐concept demonstration to analyze sweat chloride for evaluating hydration status and sweat glucose for assessing glucose levels. The low‐cost yet highly accurate device provides opportunities for clinical sweat analysis and disease screening in remote and low‐resource settings. The developed device platform can be facilely adapted for the other biomarkers when corresponding colorimetric reagents are exploited.

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Section: Resultsmentioning

confidence: 99%

Skin‐Interfaced Bifluidic Paper‐Based Device for Quantitative Sweat Analysis

Deng,

Li,

Song

et al. 2023

Advanced Science

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“…Optical biosensors can be mainly divided into direct and indirect types. The former relies on the transducers' optical properties change that induced by the binding of the analyte (e.g., surface plasmon resonance (SPR), reflectometry, interferometry, and photoluminescence) 122 (Fig. 4A).…”

Section: Optical Paper-based Printable Biosensorsmentioning

confidence: 99%

Printable biosensors towards next-generation point-of-care testing: paper substrate as an example

Liu¹,

Lu²,

Zhang³

et al. 2023

Lab Chip

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“…However, one of their areas of opportunity is the limit of detection, which may prevent their application in non-conventional fluids. To overcome this challenge, other detection approaches have been analyzed, such as detection by electrochemical methods [ 114 , 115 ], distance-based [ 83 , 116 ], luminescence [ 79 , 117 ], fluorescence [ 79 , 118 ], calorimetry [ 119 , 120 ], and mass spectra [ 121 , 122 ]. Most of the paper-based POCs reported in Table 1 of this review have reported stability under refrigeration (4 °C) [ 4 , 69 , 73 , 76 , 79 , 80 , 84 , 123 ].…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

2021

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A point-of-care (POC) can be defined as an in vitro diagnostic test that can provide results within minutes. It has gained enormous attention as a promising tool for biomarkers detection and diagnosis, as well as for screening of chronic noncommunicable diseases such as diabetes mellitus. Diabetes mellitus type 2 is one of the metabolic disorders that has grown exponentially in recent years, becoming one of the greatest challenges to health systems. Early detection and accurate diagnosis of this disorder are essential to provide adequate treatments. However, efforts to reduce incidence should remain not only in these stages but in developing continuous monitoring strategies. Diabetes-monitoring tools must be accessible and affordable; thus, POC platforms are attractive, especially paper-based ones. Paper-based POCs are simple and portable, can use different matrixes, do not require highly trained staff, and are less expensive than other platforms. These advantages enhance the viability of its application in low-income countries and hard-to-reach zones. This review aims to present a critical summary of the main components required to create a sensitive and affordable enzymatic paper-based POC, as well as an oriented analysis to highlight the main limitations and challenges of current POC devices for diabetes type 2 monitoring and future research opportunities in the field.

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Prussian Blue (bio)sensing device for distance-based measurements

Cited by 11 publications

References 40 publications

Skin‐Interfaced Bifluidic Paper‐Based Device for Quantitative Sweat Analysis

Skin‐Interfaced Bifluidic Paper‐Based Device for Quantitative Sweat Analysis

Printable biosensors towards next-generation point-of-care testing: paper substrate as an example

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

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