Prussian blue as an antidote for radioactive thallium and cesium poisoning

Altagracia-Martínez, Marina; Jaime, Kravzov-Jinich; Martínez-Núñez, Juan Manuel; Ríos-Castañeda, Camilo; López-Naranjo, Francisco

doi:10.2147/odrr.s31881

Cited by 47 publications

(29 citation statements)

References 32 publications

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“…Above all, PBNPs are suitable for their potential clinical applications because PB is already used in the clinic as a treatment for radiation exposure. 51 Furthermore, PBNPs could easily be coated with poly- l -lysine (PLL) to reduce their negative charge and facilitate cell internalization. In this study, we developed a simple and efficient method to label hMSCs with PBNPs and then used them as a contrast agent for photoacoustic stem cell imaging.…”

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confidence: 99%

Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue–Poly(l-lysine) Nanocomplexes

et al. 2017

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Acoustic imaging is affordable and accessible without ionizing radiation. Photoacoustic imaging increases the contrast of traditional ultrasound and can offer good spatial resolution when used at high frequencies with excellent temporal resolution. Prussian blue nanoparticles (PBNPs) are an emerging photoacoustic contrast agent with strong optical absorption in the near-infrared region. In this study, we developed a simple and efficient method to label human mesenchymal stem cells (hMSCs) with PBNPs and imaged them with photoacoustic imaging. First, PBNPs were synthesized by the reaction of FeCl3 with K4[Fe(CN)6] in the presence of citric acid and complexed with the cationic transfection agent poly-l-lysine (PLL). The PLL-coated PBNPs (PB-PLL nanocomplexes) have a maximum absorption peak at 715 nm and could efficiently label hMSCs. Cellular uptake of these nanocomplexes was studied using bright field, fluorescence, and transmission electron microscopy. The labeled stem cells were successfully differentiated into two downstream lineages of adipocytes and osteocytes, and they showed positive expression for surface markers of CD73, CD90, and CD105. No changes in viability or proliferation of the labeled cells were observed, and the secretome cytokine analysis indicated that the expression levels of 12 different proteins were not dysregulated by PBNP labeling. The optical properties of PBNPs were preserved postlabeling, suitable for the sensitive and quantitative detection of implanted cells. Labeled hMSCs exhibited strong photoacoustic contrast in vitro and in vivo when imaged at 730 nm, and the detection limit was 200 cells/µL in vivo. The photoacoustic signal increased as a function of cell concentration, indicating that the number of labeled cells can be quantified during and after cell transplantations. In hybrid ultrasound/photoacoustic imaging, this approach offers real-time and image-guided cellular injection even through an intact skull for brain intraparenchymal injections. Our labeling and imaging technique allowed the detection and monitoring of 5 × 104 mesenchymal stem cells in living mice over a period of 14 days.

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confidence: 99%

Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue–Poly(l-lysine) Nanocomplexes

et al. 2017

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“…Prussian‐blue acting as “artificial peroxidase”, offers a highly selective detection of the hydrogen peroxide product of oxidase biocatalytic reactions . PB has been widely used for oral treatment of poisoning by the heavy metals like thallium and cesium, and its use appears to be very safe under physiological conditions even following high oral doses . Poly‐orthophenylenediamine (PPD) is commonly employed for the electropolymeric entrapment of oxidases, rejection of potential interferences and protection of the biosensor surface .…”

Section: Mouthguard Sensors In Oral Cavitymentioning

confidence: 99%

“…Prussian-bluea ctinga s" artificial peroxidase", offers ah ighlys elective detection of the hydrogen peroxide product of oxidaseb iocatalytic reactions [155][156][157]. PB has been widely used for oral treatment of poisoning by the heavy metals like thallium and cesium,a nd its use appears to be very safe under physiologicalc onditions even following high oral doses [158][159][160].P oly-orthophenylenediamine (PPD) is commonly employed for the electropolymeric entrapmento fo xidases,r ejectiono fp otential interferences and protection of the biosensor surface [161][162][163].S uch coupling of the extremely low-potential detection of the peroxide product afforded by the PB transducer and the exclusion of electroactive constituents of whole saliva leads to high selectivity and stability.…”

Section: Lactate Sensori Noral Cavitymentioning

confidence: 99%

Cavitas Sensors: Contact Lens Type Sensors & Mouthguard Sensors

Mitsubayashi

Arakawa

2016

Electroanalysis

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“Cavitas sensors” attached to body cavities such as the contact lens and mouthguard (“no implantable”, “no wearable”) are attracted attention as self‐detachable devices for daily medicine. Many types of contact lens (CL) sensors using electrical and optical methods have been developed for monitoring not only chemicals (glucose, lactate) and electrical conductivity in tear fluid, but also transcutaneous gases at eyelid mucosa. A CL intraocular pressure telemetric sensor has been also commercialized and applied to patients for monitoring the intraocular pressure. Some mouthguard sensors have been investigated for a real‐time measurement of salivary chemicals. A graphene based sensor on tooth enamel was reported to be capable of salivary bacterium detection. Here we review the challenges regarding the integration of biosensors into monitoring for biological information of body cavities. The self‐detachable cavitas sensors are expected to improve the quality of life in the near future.

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“…Use of colorimetric analyses of these specimens can lead to false positives (CDC, 1987). Prussian Blue is the treatment of choice for Tl exposure, in that it acts by binding Tl in the gastrointestinal tract, making it unavailable for reabsorption (Altagracia-Martínez et al, 2012;Sun et al, 2012;Riyaz et al, 2013). Treatment should be initiated when 24 h urinary Tl excretion exceeds 0.5 mg. Additionally, a toxic level of Tl in the urine of >300 μg/L has been suggested (Sullivan, 1992).…”

Section: Treatmentmentioning

confidence: 99%

Thallium

Thompson¹

2015

Handbook of Toxicology of Chemical Warfare Agents

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Prussian blue as an antidote for radioactive thallium and cesium poisoning

Cited by 47 publications

References 32 publications

Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue–Poly(l-lysine) Nanocomplexes

Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue–Poly(l-lysine) Nanocomplexes

Cavitas Sensors: Contact Lens Type Sensors & Mouthguard Sensors

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