Pruritus in Diabetes Mellitus: Investigation of Prevalence and Correlation With Diabetes Control

Neilly, J. B.; Martin, Adam; Simpson, N. B.; MacCuish, A C

doi:10.2337/diacare.9.3.273

Cited by 89 publications

(41 citation statements)

References 4 publications

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“…Itch has not been considered to be associated with diabetes except in localized forms of itch associated with candida and intertrigo infections (64). In a large study, generalized pruritus without apparent cause was present in 3% (8/300) of diabetic patients, but this was not significantly more than controls (65). However, in a recent large-scale study in Japan involving more than 2500 diabetics, 11% of diabetics compared with 2% of matched controls had ttuncal pruritus; the truncal pruritus was also found to be highly associated with diabetic polyneuropathy (66).…”

Section: Diabetes Mellitusmentioning

confidence: 95%

Itch in Ethnic Populations

Tey

Yosipovitch

2010

Acta Derm Venerol

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Racial and ethnic differences in the prevalence and clinical characteristics of itch have rarely been studied. The aim of this review is to highlight possible associations between ethnicity and different forms of chronic itch. We provide a current review of the prevalence of different types of itch in ethnic populations. Genetic variation may significantly affect receptors for itch as well as response to anti-pruritic therapies. Primary cutaneous amyloidosis, a type of pruritic dermatosis, is particularly common in Asians and rare in Caucasians and African Americans, and this may relate to a genetic polymorphism in the Interleukin-31 receptor. Pruritus secondary to the use of chloroquine for malaria is a common problem for African patients, but is not commonly reported in other ethnic groups. In patients with primary biliary cirrhosis, pruritus is more common and more severe in African Americans and Hispanics compared with Caucasians. Racial and ethnic differences in itch and its medical care are poorly understood. Research is needed to examine biological, psychosocial, and lifestyle factors that may contribute to these disparities.

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Section: Diabetes Mellitusmentioning

confidence: 95%

Itch in Ethnic Populations

Tey

Yosipovitch

2010

Acta Derm Venerol

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“…5 In contrast, one study showed that generalised pruritus of unknown cause was especially common in people with diabetes (8/300 patients), but pruritus vulvae was significantly more common in women with diabetes (18.4%) compared with 100 non-diabetic controls (5.6%) and was strongly associated with poor diabetic control. 6 …”

Section: Introductionmentioning

confidence: 99%

Diabetes and pruritus

Babakinejad¹,

Walton²

2016

Br J Diabetes

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Pruritus is often reported to be associated with diabetes mellitus although this remains controversial. Careful historytaking and examination are key to establishing the cause of itching in a patient with diabetes after excluding local cutaneous disease or an underlying lymphoma. Options for management of this distressing condition include emollients, topical antipruritic agents (e.g. calamine, menthol, capsaicin, corticosteroids, calcineurin inhibitors or local anaesthetics), systemic antipruritic agents (e.g. H1 antihistamines, doxepin and gabapentin), broad-band or narrowband ultraviolet B phototherapy and psychological therapies. Br J Diabetes 2016;16:154-155

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“…Pruritus in diabetes is common but rarely if ever generalized unless it is caused by chronic renal failure. Anogenital pruritus is a common symptom of diabetes and is usually a result of candidosis [38]. Pruritus is an occasional manifestation of diabetic neuropathy.…”

Section: Neurogenic Itch Including Itch Associated With Systemic Dismentioning

confidence: 99%

Pathogenesis and Treatment of Pruritus

Greaves

2010

Curr Allergy Asthma Rep

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Classification of itch into four categories-pruritoceptive, neurogenic, neuropathic, and psychogenic-has proven to be of utility to clinicians and investigators. Itch is recognized to be transmitted by dedicated afferent neurons, and a matrix of cerebral cortical loci involved in perception and the desire to scratch has been recognized. This highlights the multidimensional nature of the itch sensation. Some of the many mediators of itch, especially relevant in pruritogenic itch, are the result of cross-talk between dermal mast cells and adjacent cutaneous afferents. Keratinocytes of the epidermis express many neuropeptides, and their receptors are far from passive bystanders in the neurophysiology of itch. Mediators can also act centrally (eg, opioid peptides that act on micro receptors in the central nervous system). The pathophysiology of pruritus in neurogenic itch caused by common systemic diseases is gradually being elucidated, especially in the itch of cholestasis, although the molecular basis of itching in chronic renal failure remains elusive. Better understanding of the mediators of itch and their receptors has led to the imminent development of novel anti-itch compounds, including interleukin-31 inhibitors, histamine H4-receptor antagonists, and neurokinin-1 receptor antagonists.

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Pruritus in Diabetes Mellitus: Investigation of Prevalence and Correlation With Diabetes Control

Cited by 89 publications

References 4 publications

Itch in Ethnic Populations

Itch in Ethnic Populations

Diabetes and pruritus

Pathogenesis and Treatment of Pruritus

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