Pruritus

Greaves, M. W.

doi:10.1002/9780470750520.ch16

Cited by 7 publications

(12 citation statements)

References 158 publications

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“…Ein ähnliches Phänomen ist die sog. Atmoknesis, bei der durch Luftexposition Pruritus auslösbar ist [8, 30].…”

Section: Klinische Manifestation Von Pruritusunclassified

“…Ein Beispiel hierfür ist die asteatotische Dermatitis des älteren Patienten. Auch bei der polymorphen Lichtdermatose kann Pruritus dem Auftreten der UV‐induzierten Papulovesikel und Erytheme um Monate vorausgehen [8, 25, 30, 58]. Bei vielen juckenden Systemerkrankungen ist der zugrundeliegende pathophysiologische Prozeß noch unklar.…”

Section: Klinische Manifestation Von Pruritusunclassified

“…Wenn eine kausale Behandlung nicht möglich ist, gewinnt die symptomatische Therapie an Bedeutung. Obgleich der Histamin‐abhängige Pruritus leicht zu beeinflussen ist, stellen alle anderen Pruritusformen ein therapeutisches Problem dar [25, 30, 58].…”

Section: Allgemeine Therapeutische Aspekteunclassified

“…Beispielsweise kann Pruritus der Manifestation eines Lymphoms um Jahre voraus gehen oder gar die einzige kutane Manifestation sein [71]. Chronischer Pruritus beeinträchtigt, ähnlich wie Schmerz, das Allgemeinbefinden des Patienten erheblich und kann im Extremfall zu physischer und psychischer Erschöpfung führen [8, 25, 30, 58].…”

Section: Introductionunclassified

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Pruritus – Pathophysiologie, Klinik und Therapie – Eine Übersicht

Ständer

Weißhaar

Steinhoff

et al. 2003

J Deutsche Derma Gesell

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Pruritus is an unpleasant sensory perception of the skin associated with the desire to scratch. As a physiological nociception, pruritus leads to the removal of harmful agents such as parasites and plants from the skin surface. More often, pruritus occurs as a severe and therapy-refractory symptom of various underlying dermatological and systemic diseases. Comparable to chronic pain, chronic pruritus worsens the general condition and may lead to physical and psychological exhaustion. Until the 1990s, pruritus had been regarded as an incomplete pain sensation. Only recently, itch was defined as a separate, pain-independent sensation with its own mediators, spinal neurons and cortical areas. These observations led to the development of new therapeutic modalities. This paper gives an overview of itch pathophysiology, clinical types and therapies.

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“…Ein ähnliches Phänomen ist die sog. Atmoknesis, bei der durch Luftexposition Pruritus auslösbar ist [8, 30].…”

Section: Klinische Manifestation Von Pruritusunclassified

Section: Allgemeine Therapeutische Aspekteunclassified

Section: Introductionunclassified

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Pruritus – Pathophysiologie, Klinik und Therapie – Eine Übersicht

Ständer

Weißhaar

Steinhoff

et al. 2003

J Deutsche Derma Gesell

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“…NO is a ubiquitous free radical with a variety of biological functions that can influence the immune system, neurotransmission, and smooth muscle relaxation [8]. The skin is an enormous organ in the human body which consists of three main layers and various cells, including keratinocytes, Langerhans cells, melanocytes, dermal dendritic cells, fibroblast, endothelial cells, and migratory lymphocytes [9]. Keratinocytes, fibroblasts, melanocytes, Langerhans, and endothelial cells express Nitric Oxide Synthase (NOS) and are capable of releasing NO [10].…”

Section: Introductionmentioning

confidence: 99%

Association of Nitric Oxide With Delayed Skin Problems After Sulfur Mustard Exposure: Part of Sardasht-Iran Cohort Study

et al. 2019

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Background: Exposure to Sulfur Mustard (SM) leads to short-and long-term adverse effects on various organs, including the skin. Despite several studies on long-term clinical manifestations of skin toxicity in SM-exposed individuals, the pathogenesis of SM-induced skin disorders is not fully understood. Materials and Methods:As part of Sardasht-Iran Cohort Study (SICS), this study aimed to find out the possibility of any correlation between the serums level of Nitric Oxide (NO) and skin problems due to the long-term effect of SM as well as the kind of skin illness. In this historical cohort study, 372 male SM-exposed subjects and 128 age-matched unexposed controls were studied. Clinical evaluation was carried out for all participants, and their serum concentration of NO was measured.Results: According to our results, the Mean±SD serum level of NO in the exposed group with skin disorders were significantly higher than that in the exposed group without skin disorders (1483.00±488.754µg/mL vs. 1364.50±487.887µg/mL; P=0.024). Also, among the exposed group, there was a significant elevation of serum NO associated with the type of lesion. For ezxample, specific lesions like mustard scar were associated with higher levels of NO compared to non-specific lesions like xerosis, itching, seborrheic dermatitis, etc. Also, a significant elevation in serum NO levels was found in the exposed subjects with pigmentation disorders (both hypo-and hyper-pigmentation) compared to the exposed participants without these skin problems (P<0.05). Finally, a significant difference in the serum level of NO was seen between the SM-exposed and the control subjects with no cherry angioma (P<0.05). Conclusion:Our results show the highest serum level of NO in the exposed group with specific lesions and the lowest or normal level of NO in the unexposed group with no skin illness. The elevated serum levels of NO may be associated with the progression of some skin complications in the SM-exposed subjects. This finding serves as a basis for further research on the molecular mechanisms and pathways involved in the pathogenesis of skin disorders in SM-exposed patients.

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Aetiological factors in vulvar dermatitis

Wojnarowska

et al. 2000

Acad Dermatol Venereol

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Pruritus

Cited by 7 publications

References 158 publications

Pruritus – Pathophysiologie, Klinik und Therapie – Eine Übersicht

Pruritus – Pathophysiologie, Klinik und Therapie – Eine Übersicht

Association of Nitric Oxide With Delayed Skin Problems After Sulfur Mustard Exposure: Part of Sardasht-Iran Cohort Study

Aetiological factors in vulvar dermatitis

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