Pruritic erythematous linear plaques on the neck and back. "Flagellate" erythema secondary to bleomycin therapy

Lindae, Mary L.

doi:10.1001/archderm.123.3.395

Cited by 11 publications

(1 citation statement)

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“…There does not seem to be a characteristic distribution as cases have shown involvement of the face, trunk and extremities. Dermatographia is present to a limited extent and the role of scratching in producing the linear shape of the lesions has been debated (15). However, studies have shown the clear appearance of linear streaks in the absence of direct trauma (5).…”

Section: Discussionmentioning

confidence: 99%

Bleomycin-induced flagellate erythema: A case report and review of the literature

et al. 2014

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Bleomycin has been used most commonly in the treatment of Hodgkin’s lymphoma, certain germ cell tumors (GCT) and for the sclerosis of recurrent pleural effusions. Bleomycin toxicity predominantly affects the skin and lungs. Skin toxicity includes Raynaud’s phenomenon, hyperkeratosis, nail-bed changes and palmoplantar desquamation. Flagellate erythema is an unusual rash occurring specifically during bleomycin use. In the present study, we report a case of bleomycin-induced flagellate erythema in a patient with GCT. A 42-year-old male was diagnosed with stage IIIB testicular cancer and treated with bleomycin, etoposide and cisplatin chemotherapy. After 10 days from the initiation of treatment, the patient subsequently developed a generalized pruritus and erythematous linear rash that was most prominent on the trunk, and upper and lower extremities. The patient was commenced on a short course of low-dose oral prednisolone, 20 mg daily, and antihistamine. Consequently, bleomycin was withheld from the patient’s treatment regimen. The present study describes the case, along with a review of the associated literature.

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Section: Discussionmentioning

confidence: 99%

Bleomycin-induced flagellate erythema: A case report and review of the literature

et al. 2014

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Bleomycin induced hyperpigmentation with yolk sac tumor

et al. 2007

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Hyperpigmentation is one of the cutaneous side effects of chemotherapautic agents, but it is usually accepted as a cosmetic problem. We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin. The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.

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