Bleomycin induced hyperpigmentation with yolk sac tumor

Yarış, Nilgün; Çakır, Murat; Kalyoncu, Mukaddes; Ökten, Ayşenur

doi:10.1007/s12098-007-0089-8

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…This phenomenon is noted to occur between 24 hours and 9 weeks following treatment, with an incidence of 8% to 38% . Cutaneous hyperpigmentation does not seem to be dose related, as it has been reported with a dose as low as 5 mg given parentally . The mechanism of cutaneous hyperpigmentation is unknown.…”

Section: Discussionmentioning

confidence: 92%

“…A more commonly encountered bleomycin side effect is cutaneous—flagellate—hyperpigmentation . This phenomenon is noted to occur between 24 hours and 9 weeks following treatment, with an incidence of 8% to 38% .…”

Section: Discussionmentioning

confidence: 99%

“…A more commonly encountered bleomycin side effect is cutaneous-flagellate-hyperpigmentation. [31][32][33][34][35] This phenomenon is noted to occur between 24 hours and 9 weeks following treatment, with an incidence of 8% to 38%. 31 Cutaneous hyperpigmentation does not seem to be dose related, as it has been reported with a dose as low as 5 mg given parentally.…”

Section: Discussionmentioning

confidence: 99%

“…31 Cutaneous hyperpigmentation does not seem to be dose related, as it has been reported with a dose as low as 5 mg given parentally. 33 The mechanism of cutaneous hyperpigmentation is unknown. Proposed mechanisms include localized increase in melanogenesis, pigmentary incontinence secondary to inflammation, alterations in normal pigmentation patterns, and toxic effects of the drug itself, inducing neutrophilic eccrine hidradenitis.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic transmucosal direct puncture sclerotherapy for management of airway vascular malformations

et al. 2015

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A multidisciplinary approach to airway vascular malformations with a combination of endoscopy and direct puncture bleomycin sclerotherapy was demonstrated to be a safe and effective treatment in our patient cohort. Direct laryngoscopy and nasopharyngoscopy provide easy access to the nasopharynx, oropharynx, retro- and/or parapharyngeal spaces and larynx. Unlike traditional agents, bleomycin induces minimal edema and therefore is an ideal substance to treat airway lesions.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endoscopic transmucosal direct puncture sclerotherapy for management of airway vascular malformations

et al. 2015

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“…It is reported that FH can manifest after bleomycin dosages ranging from 5 U up to 465 U (15). Yaris et al reported a child patient undergone treatment with such a low dose as 5 U, with the parental consent (16). The linear or streaked pigmentation usually develops after a cumulative dose between 100-300 U of bleomycin (6,17), whereas considering our cases the cumulative doses were 38 U and 30 U.…”

Section: Discussionmentioning

confidence: 70%

Flagellate Hyperpigmentation Following Treatment with Low-Dose Bleomycine: Report of two cases

Cokmert¹,

Demir²,

Akyol³

2015

Acta Oncol Tur.

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ÖZETBleomisin'in mukokutanöz yan etkileri, 100 U'den daha yüksek kümülatif dozları alan hastalarda yaygındır. Flagella benzeri hiperpigmentasyon bleomisin kullanımının neden olduğu, vakaların yaklaşık % 8-20'sinde görülen ilginç bir cilt reaksiyonudur. Mekanizması bilinmemektedir. Tanı karakteristik klinik görünüme dayanmaktadır. Hiperpigmente cilt lezyonlarının histolojik incelemesi, bazal keratinositlerde artmış melanin içeriğini ortaya koymaktadır. Hafif vakalar antihistaminiklere ve/veya sistemik steroide yanıt verir fakat birçok vakada ilacın kesilmesi gerekebilir. Biz rölatif olarak daha düşük (kümülatif dozlar 30 ve 38 U) dozlarla bleomisin kaynaklı flagella benzeri hiperpigmentasyonu olan 2 vaka sunuyoruz. Bleomisin kullanan hastalarda hiç de nadir olmayan bu komplikasyonu klinisyenler akılda bulundurmalıdırlar. Anahtar Kelimeler: Hiperpigmentasyon, Bileomisin, Cilt ABSTRACT Mucocutaneus side effects of bleomycin therapy are common in patients receiving cumulative doses greater than 100 U (100 mg). Flagellate hyperpigmentation is an interesting cutaneus reaction caused by bleomycin use, and is seen in about 8-20% of cases. The mechanism is unknown. Diagnosis is based on its characteristic clinical appearance. Histological examination of hyperpigmented skin lesions has demonstrated increased melanin content in basal keratinocytes. It has been suggested that mild cases may respond to antihistamines and ⁄ or systemic steroids, but in many cases discontinuation of the drug may be necessary. We present two patients (cumulative doses of 30 and 38 U) that developed bleomycin-induced flagellate hyperpigmentation with relatively low doses. Because the condition is not uncommon in patients who are using this drug, the clinician should be mindful of this complication.

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Current awareness: Pharmacoepidemiology and drug safety

2008

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Bleomycin induced hyperpigmentation with yolk sac tumor

Cited by 5 publications

References 5 publications

Endoscopic transmucosal direct puncture sclerotherapy for management of airway vascular malformations

Endoscopic transmucosal direct puncture sclerotherapy for management of airway vascular malformations

Flagellate Hyperpigmentation Following Treatment with Low-Dose Bleomycine: Report of two cases

Current awareness: Pharmacoepidemiology and drug safety

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