Prurigo Nodularis and Uremia

Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients

“…Histological data on a total of 135 patients with PN are available in the relevant literature (Table 1). About 19 papers including case reports describe different findings, but mainly hyperkeratosis, acanthosis, papillomatosis, irregular elongation of rete ridges, or a dermal inflammatory infiltrate 9,10,13,14,16–30 . Overall, only few criteria and nondetailed descriptions were presented.…”

Advanced glycation end product (AGE)-immunoreactive materials in chronic prurigo patients receiving a long-standing haemodialysis

“…Patients with renal failure frequently have generalized severe pruritus. In one study, up to 85% of patients on haemodialysis suffered from itching, and the high incidence of prurigo nodularis in chronic renal failure/haemodialysis patients is considered to be due to repeated localized scratching and rubbing 4 …”

“…In one study, up to 85% of patients on haemodialysis suffered from itching, and the high incidence of prurigo nodularis in chronic renal failure ⁄ haemodialysis patients is considered to be due to repeated localized scratching and rubbing. 4 Incubation of proteins with high glucose leads to advanced glycation end products (AGEs) through the Maillard reaction. Several AGE structures including pyrraline, pentosidine, and N e -(carboxymethyl) lysine (CML) have been identified and demonstrated to play a potential role in the pathogenesis of ageing and the complications of diabetic and nondiabetic renal failures.…”