Advanced glycation end product (AGE)-immunoreactive materials in chronic prurigo patients receiving a long-standing haemodialysis

Abstract

We report two patients with chronic prurigo who suffered from chronic renal failure and were treated by haemodialysis. Histological examination of pruritic nodules revealed that the papillary dermis of the lesional skin was eosinophilic and amorphous, and free from dermal cell infiltration. Immunohistochemical study demonstrated that advanced glycation end product (AGE)-immunoreactive materials accumulated in the papillary dermis of the lesional skin. This immunohistochemical finding was never observed in the nonlesional skin adjacent to prurigo nodules of the present cases, and renal disease-free prurigo skin (n = 6) and nonprurigo skin of haemodialysis patients (n = 3). AGE-modified materials in the papillary dermis may be related to the pathogenesis of prurigo nodules in the haemodialysis patients.

Role of Advanced Glycation Endproducts and Potential Therapeutic Interventions in Dialysis Patients

“…In this study, AGE deposits were only observed in the prurigo nodules, but not in the adjacent nonlesional skin in these patients. In addition, a lack of AGE deposits was also noted in renal‐disease free prurigo skin as well as in nonprurigo skin of HD patients (81).…”

“…As studies have shown enhanced AGE deposition in the skin of HD patients (as measured by skin autofluorescence) is associated with both overall and cardiovascular mortality, other dialysis related complications have also been assessed using skin autofluorescence (69). For example, in a case series from 2004, an association was observed between the deposition of immunoreactive AGEs in the papillary dermis of long‐term HD patients with chronic prurigo (81). In this study, AGE deposits were only observed in the prurigo nodules, but not in the adjacent nonlesional skin in these patients.…”

Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia

“…Thus, the accumulation of skin AGEs also might be involved in the pathophysiology underlying drug‐induced photosensitivity. Indeed, the accumulation of AGEs in skin has been shown to be involved in the pathophysiology of some dermatological diseases, such as solar elastosis (Yoshinaga et al, ), prurigo nudularis in dialysis patients (Dyer et al, ; Meng et al, ), and perforating dermatosis (Fujimoto & Tajima, ; Seite et al, ).…”