Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing

Li, Jingzhen; Liu, Fei; Lv, Yuexia; Sun, Kui; Zhao, Yuntong; Reilly, Jamas; Zhang, Yangjun; Tu, Jiayi; Yu, Shanshan; Liu, Xiliang; Qin, Yayun; Huang, Yu-Wen; Gao, Pan; Jia, Danna; Chen, Xiang; Han, Yunqiao; Shu, Xinhua; Luo, Daji; Tang, Zhaohui; Liu, Mugen

doi:10.1093/nar/gkab003

Cited by 24 publications

(24 citation statements)

References 61 publications

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“…PRPF31 (pre-mRNA processing factor 31) is an important protein required for pre-mRNA splicing between 4/U6 disnRNA and the U5 snRNP [ 21 ]. PRPF31 has been found to have loss of function, leading in lower quantities of active snRNPs and worse splicing efficiency [ 22 ]. APEX1 (APEX nuclease (multifunctional DNA repair enzyme) 1) may assume a part in malignancy by repairing DNA harm [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis

Arulprakasam

Pandi

Dhandapani

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes and reveal its molecular mechanism. In order to explore the potential facts for gastric cancer, the expression profiles of two different datasets were used (GSE161533 and GSE54129). The genes were confirmed to be part of the PPI network for gastric cancer pathogenesis and prognosis. In Cytoscape, the CytoHubba module was used to discover the hub genes. Responsible hub genes were identified. Data from Kaplan–Meier plotter confirmed the predictive value of these distinct genes in various stages of gastric malignancy. Upregulated and downregulated genes were identified to utilize for further analysis. Positive regulation by a host of viral process, positive regulation of granulocyte differentiation, negative regulation of histone H3–K9 methylation were found in DEGs analysis. In addition, five KEGG pathways were identified as an essential enhancer that include nucleotide excision repair; base excision repair; DNA replication; homologous recombination; and complement and coagulation cascades. POLE, BUB1B, POLD4, C3, BLM, CCT7, PRPF31, APEX1, PSMA7, and CDC45 were chosen as hub genes after combining the PPI results. Our study recommends that BUB1B, CCT7, APEX1, PSMA7, and CDC45 might be potential biomarkers for gastric cancer. These biomarkers are upregulated genes. Therefore, suppression of these genes will increase the survival rate in gastric cancer patients.

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Section: Discussionmentioning

confidence: 99%

In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis

Arulprakasam

Pandi

Dhandapani

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Longer rod Oss. Delayed development of OSs [125] prpf31 Decreased in neuronal precursors and mature neurons at both 48 and 60 hpf [126] rho…”

Section: Gene Photoreceptor Features Reference Adipor1mentioning

confidence: 99%

Zebrafish Model in Ophthalmology to Study Disease Mechanism and Drug Discovery

Hong

Luo

2021

Pharmaceuticals

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Visual impairment and blindness are common and seriously affect people’s work and quality of life in the world. Therefore, the effective therapies for eye diseases are of high priority. Zebrafish (Danio rerio) is an alternative vertebrate model as a useful tool for the mechanism elucidation and drug discovery of various eye disorders, such as cataracts, glaucoma, diabetic retinopathy, age-related macular degeneration, photoreceptor degeneration, etc. The genetic and embryonic accessibility of zebrafish in combination with a behavioral assessment of visual function has made it a very popular model in ophthalmology. Zebrafish has also been widely used in ocular drug discovery, such as the screening of new anti-angiogenic compounds or neuroprotective drugs, and the oculotoxicity test. In this review, we summarized the applications of zebrafish as the models of eye disorders to study disease mechanism and investigate novel drug treatments.

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“…The depletion of Sf3A2 and PrP31 resulted in defective spindle assembly formation, metaphase arrest and aberrations in chromosome segregation [ 162 ]. Additionally, the depletion of PrP31 influenced the alternative splicing of the genes involved in mitosis and DNA repair during the early stages of embryogenesis [ 163 ].…”

Section: Link Between Alterations In Rna Processing Factors and Chrom...mentioning

confidence: 99%

The Interplay of Cohesin and RNA Processing Factors: The Impact of Their Alterations on Genome Stability

Osadska

Selicky

Kretova

et al. 2022

IJMS

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Cohesin, a multi-subunit protein complex, plays important roles in sister chromatid cohesion, DNA replication, chromatin organization, gene expression, transcription regulation, and the recombination or repair of DNA damage. Recently, several studies suggested that the functions of cohesin rely not only on cohesin-related protein–protein interactions, their post-translational modifications or specific DNA modifications, but that some RNA processing factors also play an important role in the regulation of cohesin functions. Therefore, the mutations and changes in the expression of cohesin subunits or alterations in the interactions between cohesin and RNA processing factors have been shown to have an impact on cohesion, the fidelity of chromosome segregation and, ultimately, on genome stability. In this review, we provide an overview of the cohesin complex and its role in chromosome segregation, highlight the causes and consequences of mutations and changes in the expression of cohesin subunits, and discuss the RNA processing factors that participate in the regulation of the processes involved in chromosome segregation. Overall, an understanding of the molecular determinants of the interplay between cohesin and RNA processing factors might help us to better understand the molecular mechanisms ensuring the integrity of the genome.

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Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing

Cited by 24 publications

References 61 publications

In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis

In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis

Zebrafish Model in Ophthalmology to Study Disease Mechanism and Drug Discovery

The Interplay of Cohesin and RNA Processing Factors: The Impact of Their Alterations on Genome Stability

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