Visual impairment and blindness are common and seriously affect people’s work and quality of life in the world. Therefore, the effective therapies for eye diseases are of high priority. Zebrafish (Danio rerio) is an alternative vertebrate model as a useful tool for the mechanism elucidation and drug discovery of various eye disorders, such as cataracts, glaucoma, diabetic retinopathy, age-related macular degeneration, photoreceptor degeneration, etc. The genetic and embryonic accessibility of zebrafish in combination with a behavioral assessment of visual function has made it a very popular model in ophthalmology. Zebrafish has also been widely used in ocular drug discovery, such as the screening of new anti-angiogenic compounds or neuroprotective drugs, and the oculotoxicity test. In this review, we summarized the applications of zebrafish as the models of eye disorders to study disease mechanism and investigate novel drug treatments.

The precursor influences on Ni/Co metal−organic frameworks' (Ni/Co-MOFs') structure and electrochemical performances were studied, and highly enhanced Ni/Co-MOF nanosheets was obtained from a nitrate precursor and named as MN. Compared with the Ni/Co-MOF nanosheets obtained from a chloride precursor under the same concentration (labeled as MC), the nitrate developed MN exhibited a much thinner and crossarranged nanosheets' structure, which contained a higher Ni/Co ratio (MN, 1.82; MC, 1.47). These structural differences led to totally different electrochemical behaviors. At 1 A/g, the MN thinner nanosheets showed a superior specific capacitance of 2860 F/g, which remained above 90% after 2000 cycles. On the contrary, the MC thicker nanosheets had a maximum specific capacitance of 1350 F/g at 1 A/g, and it decreased to around 47% after 500 cycles. With an energy density of 88.84 Wh/kg and a power density of 750.89 W/kg, the MN thinner nanosheets also performed well in asymmetric solid-state supercapacitors.

For increasing the specific capacitance of supercapacitors, boron-doped g-C 3 N 4 quantum dots (B-CNQDs) were synthesized by KOH cutting and further adsorbed on the surface of Ni(OH) 2 nanoflowers (B-CNQDx-Ni) by a mild impregnation method via electrostatic force. The B-CNQDx-Ni nanocomposites exhibit an increased surface area and reduced band gap energy compared with pure Ni(OH) 2 , which result in a larger contact area between the electrode and the electrolyte and enhanced chargetransfer kinetics. The best B-CNQDx-Ni sample has an excellent specific capacitance of 1700 F/g at 1.5 A/g, low impedance at the alkaline conduction of 7.421 Ω, and a high stability cycling performance of 82% capacity retention after 5000 cycles, suggesting that B-CNQDx-Ni is a type of suitable electrode material used in supercapacitors. KEYWORDS: Boron-doped g-C 3 N 4 quantum dots, KOH cutting, Ni(OH) 2 nanoflowers, supercapacitors, impregnation method

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This chapter examined young consumer vulnerability by focusing on young consumers aged 11-17 to identify relevant issues associated with young consumer vulnerability from a marketing perspective. Young consumers are considered vulnerable when compared with adult consumers. Young consumers are commonly targeted by companies in the marketplace, from sectors such as beauty, luxury goods, alcohol, snack foods, e-sports, online gambling, or impulse purchases of other product categories. The authors discussed the potential issues of current marketing practices in targeting young consumers and the efforts that have been made so far by companies to address the issue of young consumer vulnerability by including five case company examples of young consumer inclusion. In addition, they discussed the ethical and marketing implications for brands in targeting young consumers, aiming for more equity and inclusion.

Introduction: Vascular endothelial cell injury and angiogenesis induced by hyperglycemia are the main pathological basis of vascular complications in diabetes mellitus. The purpose of our study was to investigate the role and mechanism of miR-210-3p on high glucose-induced angiogenesis. Methods: Human umbilical vein endothelial cells (HUVECs) were treated with high glucose (HG) to mimic the pathological process of hyperglycemia. HUVECs were divided into the Control group, HG group, HG+inhibitor-NC group, and HG+miR-210-3p inhibitor group. Proliferation and migration were tested by wound healing assay, tube formation, and Transwell assay. Quantitation real-time PCR and Western blots were performed to determine the expression of miR-210-3p and relative proteins, respectively. Results: The level of miR-210-3p significantly increased in HUVECs treated by HG. The knockdown of miR-210-3p attenuated the tube formation, proliferation, and migration of cultured HUVECs in vitro to inhibit angiogenesis by increasing the expression of fibroblast growth factor receptor-like 1 (FGFRL1) and then attenuating the phosphorylation of STAT3, ERK, and ATK. Conclusion: Our study revealed that miR-210-3p might be a promising target for the treatment of diabetic-associated vascular injury.

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