PRP and BMAC for Musculoskeletal Conditions via Biomaterial Carriers

Yamaguchi, Fabio S.M.; Shams, Shahin; Silva, Eduardo A.; Stilhano, Roberta Sessa

doi:10.3390/ijms20215328

Cited by 18 publications

(18 citation statements)

References 139 publications

(180 reference statements)

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“…Given that bone marrow contains a complex environment of many cell populations, the use of BMA clot may represent a viable alternative, able to reduce the costs and drawbacks linked to the expansion of cells from the BM, in terms of regulatory compliance and the investment required for the manipulation and storage of biological materials. To elaborate, obtaining BMAC is invasive, requires closed systems during preparation, and the positive results are strongly correlated with the number of stem cells [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Aspirate Matrix: A Convenient Ally in Regenerative Medicine

Lana¹,

Fonseca

Azzini³

et al. 2021

IJMS

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The rise in musculoskeletal disorders has prompted medical experts to devise novel effective alternatives to treat complicated orthopedic conditions. The ever-expanding field of regenerative medicine has allowed researchers to appreciate the therapeutic value of bone marrow-derived biological products, such as the bone marrow aspirate (BMA) clot, a potent orthobiologic which has often been dismissed and regarded as a technical complication. Numerous in vitro and in vivo studies have contributed to the expansion of medical knowledge, revealing optimistic results concerning the application of autologous bone marrow towards various impactful disorders. The bone marrow accommodates a diverse family of cell populations and a rich secretome; therefore, autologous BMA-derived products such as the “BMA Matrix”, may represent a safe and viable approach, able to reduce the costs and some drawbacks linked to the expansion of bone marrow. BMA provides —it eliminates many hurdles associated with its preparation, especially in regards to regulatory compliance. The BMA Matrix represents a suitable alternative, indicated for the enhancement of tissue repair mechanisms by modulating inflammation and acting as a natural biological scaffold as well as a reservoir of cytokines and growth factors that support cell activity. Although promising, more clinical studies are warranted in order to further clarify the efficacy of this strategy.

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Section: Discussionmentioning

confidence: 99%

Bone Marrow Aspirate Matrix: A Convenient Ally in Regenerative Medicine

Lana¹,

Fonseca

Azzini³

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…7,8,10,11,21 There have been several clinical studies supporting the use of BMAC for the treatment of cartilage lesions. 9,10,[22][23][24][25] As the use of BMAC for osteochondral lesions continues to be evaluated, we offer a technique for use in treating OCD lesions, with tips from our experience in implementing this technique. Another technique has described in which the parent bone of an OCD undergoes microfracture to release mesenchymal cells on the parent bone.…”

Section: Discussionmentioning

confidence: 99%

Arthroscopic Fixation of Knee Femoral Condyle Osteochondritis Dissecans Fragment With Bone Marrow Aspirate Concentrate

Massey¹,

McClary²,

McBride³

et al. 2021

Arthroscopy Techniques

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This article reviews a technique for arthroscopic fixation of an osteochondritis dissecans fragment with bone marrow aspirate concentrate augmentation. This technique involves safe harvest of bone marrow arthroscopically from the intercondylar notch, proper preparation and debridement of the parent bone, reduction of the progeny osteochondritis dissecans fragment, insertion of the bone marrow aspirate concentrate, and placement of multiple headless compression screws for fixation.

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“…MSCs present in BMAC products are multipotent stem cells and have been used in the orthopedic field due to their strong self-renewal capacity along with the potential to differentiate into all musculoskeletal lineages. MSCs are a secretory organ of cytokines, chemokines, GFs, and anti-inflammatory molecules that promote the recovery of the injured tissue[ 8 ]. According to The International Society for Cellular Therapy Position Statement, there are four minimum criteria for MSC identification: (1) MSCs must be plastic-adherent when cultured under standard conditions; (2) MSCs must demonstrate the capacity for osteogenic, adipogenic, and chondrogenic differentiation; (3) MSCs must express CD73, CD90, and CD105; and (4) MSCs must lack expression of hematopoietic lineage markers ( e.g.…”

Section: Bmacmentioning

confidence: 99%

“…The use of BMAC in clinical trials is relatively new when compared to PRP. However, good to excellent results have been demonstrated, especially in the treatment of chondral lesions[ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma vs bone marrow aspirate concentrate: An overview of mechanisms of action and orthobiologic synergistic effects

Lana¹,

Fonseca²,

Macedo³

et al. 2021

WJSC

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The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past decade. Currently, there are multiple alternatives available as suitable treatments; however, the use of autologous blood-derived products such as platelet-rich plasma (PRP), bone marrow aspirate (BMA) and BMA concentrate (BMAC), specifically, is expanding. Although many investigations attempted to demonstrate the effectiveness of these therapies, even with positive results, the literature lacks standardized protocols and overall accuracy in study designs, which leads to variance and difficulty in reproducibility of protocols. The efficacy of PRP for the treatment of cartilage, bone and muscle tissues is well known. Although BMAC has generated optimistic results for the same purposes, its applicability in clinical trials is still relatively recent when compared to PRP. Both products demonstrate the potential to set forth reparative processes, each in their own distinct mechanism. The combination of these biological products has been previously proposed, yet little is known about their synergism. Evidence indicates that growth factor, cytokine, and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal healing. BMAC products seem to work well without PRP; however, the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow itself. Nevertheless, additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy.

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PRP and BMAC for Musculoskeletal Conditions via Biomaterial Carriers

Cited by 18 publications

References 139 publications

Bone Marrow Aspirate Matrix: A Convenient Ally in Regenerative Medicine

Bone Marrow Aspirate Matrix: A Convenient Ally in Regenerative Medicine

Arthroscopic Fixation of Knee Femoral Condyle Osteochondritis Dissecans Fragment With Bone Marrow Aspirate Concentrate

Platelet-rich plasma vs bone marrow aspirate concentrate: An overview of mechanisms of action and orthobiologic synergistic effects

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