Proximity hybridization induced DNA assembly for label-free surface-enhanced Raman spectroscopic detection of carcinoembryonic antigen

Target-Responsive DNA Nanoclaw for the On-Site Identification of Chinese Medicines with Naked Eye

“…With the development of DNA nanotechnology − and artificial synthesis of oligonucleotides, DNA probes have attracted more and more attention in nucleic acid assay and biomedical applications due to their programmability and excellent specificity, and the implemented signal amplification strategies, including enzyme reactions, − catalytic hairpin assembly (CHA), and programmed catalytic self-assembly, achieve high sensitivity for targets with low abundance . Additionally, the combination of inorganic nanomaterials with unique physicochemical properties further expands the application of DNA probes.…”

A methylene blue-functionalized DNA concatemer for the construction of a turn-off fluorescent immunosensor for the sensitive detection of carcinoembryonic antigen

“…1 Currently, CEAs are considered among the most common tumor biomarkers that can provide monitoring information for cancer treatment. So far, various analytical methods have been developed to detect CEAs, such as enzyme-linked immunosorbent assay (ELISA), 2 chemiluminescence immunoassay (CLIA), 3 electrochemical methods (EC), 4 colorimetric sensing, 5 surface-enhanced Raman spectroscopy, 6 and fluorescence sensing. 7 Among them, fluorescence sensing has become popular and received wide attention due to its simple operation, fast response, low cost, and high sensitivity.…”

Ultrasensitive Electrochemical Detection of Carcinoembryonic Antigen with a Label‐Free Immunosensor Using Gold Nanoparticle‐Decorated Poly(pyrrole‐co‐3,4‐ethylenedioxythiophene)

“…[6] These methods are fluoroimmunoassay, [7] chemiluminescence immunoassays, [8] enzyme-linked immunosorbent assay, [9] radioimmunoassay, [10] and surface-enhanced Raman spectroscopy. [11] However, it is known that these methods have many disadvantages such as the need for complex and expensive instruments, time-consuming processes, low detection, and the use of potentially dangerous reagents. On the other hand, compared with other traditional immunoassay methods, electrochemical immunosensors have been superior to other methods due to their essential advantages such as device simplicity, small analytical volumes, simple pretreatment procedure, low cost, high sensitivity, and selectivity.…”

“…Immunoassays examining the special relationship between antigen and antibody are important analytical methods used in clinical research and biochemical analyses due to their high sensitivity and specificity [6] . These methods are fluoroimmunoassay, [7] chemiluminescence immunoassays, [8] enzyme‐linked immunosorbent assay, [9] radioimmunoassay, [10] and surface‐enhanced Raman spectroscopy [11] . However, it is known that these methods have many disadvantages such as the need for complex and expensive instruments, time‐consuming processes, low detection, and the use of potentially dangerous reagents.…”