“Proximal-type” epithelioid sarcoma vs. malignant rhabdoid tumor of the vulva: A case report, review of the literature, and an argument for consolidation

Argenta, Peter A.; Thomas, Sajeena G.; Chura, Justin C.

doi:10.1016/j.ygyno.2007.05.045

Cited by 55 publications

(70 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However adjuvant radiotherapy did not show statistically significant reduction in mortality from the disease. 2 Other reports advocate adjuvant radiotherapy in the presence of high-grade tumors or inadequate surgical margins. 6 The role of postoperative chemotherapy is questionable.…”

Section: Discussionmentioning

confidence: 99%

“…6 The role of postoperative chemotherapy is questionable. Argenta et al 2 reported in a study of 31 cases of vulva epithelioid sarcoma or malignant rhabdoid tumor that adjuvant chemotherapy were applied as a front-line therapy in 7 patients, of which 3 were disease free at 8, 11, and 21 months. The other 4 died of disseminated disease within 8 months of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…1 Epithelioid sarcomas of the vulva are extremely rare, and only 20 cases have been reported in the literature so far. 2,3 Epithelioid sarcomas occurring in the perineum and pubic regions have a higher rate of local recurrence and distant metastasis than those occurring in the upper and lower extremities. For this reason, epithelioid sarcomas are classified into "distal type" that occurs in the upper and lower extremities, and "proximal type" that occurs in the trunk and pubic region.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A case of epithelioid sarcoma arising in the vulva

2008

View full text Add to dashboard Cite

Epithelioid sarcoma of vulva is extremely rare. Only 20 cases have been reported in the literature so far. Early diagnosis is difficult because of its benign appearance as a painless subcutaneous nodule. Therefore treatment can be delayed, although epithelioid sarcoma requires prompt surgery. We report a case of epithelioid sarcoma that occurred in the left vulva with a brief review of literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A case of epithelioid sarcoma arising in the vulva

2008

View full text Add to dashboard Cite

show abstract

“…17 Epithelioid sarcoma (ES) is a very aggressive undifferentiated soft-tissue sarcoma with extremely rare presentation on the vulva (2% of cases). 18,19 About 20 cases in the world literature have been described; more than half of them have a poor prognosis, while single cases were reported as successfully treated. 18 'Proximal' type epithelioid sarcoma (PES) and malignant rhabdoid tumor (MRT) are believed to represent closely related lesions, probably belonging to the same clinicopathologic spectrum.…”

Section: Leiomyosarcoma Of the Vulvamentioning

confidence: 99%

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

Chokoeva¹,

Tchernev

Cardoso

et al. 2015

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Their incidence has increased dramatically during recent years, probably due to the different sexual habits and changes in the prevalence of HIV/ AIDS and HPV virus carriers, among other factors. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety eight percent of all vulvar tumors are benign and only 2% are malignant. The overall incidence of tumors with vulvar location is between two and seven cases per 100,000 women, and it increases with age, while the death rate is estimated at 0.7 per 100,000 women. Sarcomas of the vulva comprise approximately 1-3% of all vulvar cancers, with leiomyosarcomas, epithelioid sarcomas, and rhabdomyosarcomas being the most common among them. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In this paper, we present the most common forms of sarcomas of the vulva (leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, rhabdomyosarcoma) in order to emphasize the broad differential diagnosis, rare appearance, non-specific clinical picture, aggressive course, and high mortality.

show abstract

“…Varios estudios realizados sobre casos de sarcomas epitelioides proximales en periné y vulva demuestran que una escisión parcial inicial favorece la ARTICLE IN PRESS aparición de recurrencias y metástasis [3][4][5][6][7] . En cuanto al papel de la adyuvancia, no hay datos concluyentes todavía, por lo que su administración no está clara 6 , aunque se sabe que en casos de tumores T1 con posterior estudio anatomopatoló-gico de márgenes libres, la cirugía sola es suficiente, no requiere adyuvancia 4 y sólo debe mantenerse un buen seguimiento clínico de la enfermedad.…”

Section: Discussionunclassified