Provoked seizures and status epilepticus in a pediatric population with COVID‐19 disease

Thongsing, Apirada; Eizadkhah, Donya; Fields, Cheryl M.; Ballaban‐Gil, Karen

doi:10.1111/epi.17293

Cited by 30 publications

(35 citation statements)

References 16 publications

(20 reference statements)

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“…The complex febrile seizure proportion in the pandemic was also significantly higher than that of the corresponding pre-pandemic period (15.4%, 28/182 patients). This increased ratio is similar to that reported in a recent study, where an increase in complex febrile seizures in pediatric patients (88%, 14/16 patients) during the resurgence of COVID-19 was observed [9]. However, in two other studies, the proportion of complex febrile seizures to total febrile seizures was reported to be approximately 32% and 22%, respectively [2,10].…”

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confidence: 90%

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Complex Febrile Seizures in Children with COVID-19 Infection

et al. 2023

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Coronavirus disease 2019 , first reported in Wuhan, China in 2019, is an infectious disease caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The incidence rate is lower in children than in adults, but as the number of infected patients has increased recently, the number of pediatric patients has also increased [1,2]. The typical symptoms of COVID-19 include fever, cough, chills, aches, headaches, anorexia, and anosmia [1]. Neurological manifestations can also occur in patients with COVID-19. Several studies have reported neurological manifestations of COVID-19 in children [1][2][3][4]. Panda et al. [4] reviewed these manifestations and reported that 16% of all such patients showed non-specific neurological symptoms, such as headache, myalgia, and fatigue, whereas 1% of them showed specific neurological symptoms, such as seizures and encephalopathy. Another study reported that neurological manifestations, including febrile and non-febrile seizures, were observed in 3% of children with COVID-19 [1].Febrile seizures are relatively common neurologic disorders, affecting 2% to 5% of children under the age of 5 years. There are two types of febrile seizures: simple and complex seizures. Simple febrile seizures refer to generalized seizures

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confidence: 90%

“…proximately 20% to 30% of all febrile seizures are complex [5,6]. Several cases of febrile seizures have been reported in patients with COVID-19, indicating that SARS-CoV-2 can cause febrile seizures [2,[7][8][9][10].…”

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confidence: 99%

Complex Febrile Seizures in Children with COVID-19 Infection

et al. 2023

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“…According to this study, most patients presented with simple febrile seizures 26 . In contrast, subsequent studies have mentioned cases presenting febrile seizures of atypical ages and severe complex febrile/provoked seizures like our outcomes 27–29 . In addition, patients without a history of epilepsy presented with status epilepticus have been reported due to Omicron subvariant BA.1 infection in Japan 30 .…”

Section: Discussionmentioning

confidence: 67%

The diversity in the clinical features of children hospitalized with COVID‐19 during the nonvariant, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variant periods of SARS CoV‐2: Caution for neurological symptoms in Omicron variant

Şahin

Karadağ‐Öncel

Buyuksen

et al. 2023

Journal of Medical Virology

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Since the COVID-19 pandemic began, various severe acute respiratory syndrome coronavirus 2 variants have been identified with different characteristics than the nonvariant strain. We retrospectively evaluated the demographic and clinical differences in the cohort of hospitalized COVID-19 children (1 month-18 years old) between March 11, 2020, and September 31, 2022, by the time the variants identified in our country predominate. Bonferroni post hoc analysis was performed to compare the differences between the periods. Of the 283 children in this study, 142 (50.2%) were females. The median age was 36 (interquartile range [IQR]: 7-132) months. Sixty-three (22.2%) patients were hospitalized in the nonvariant period, 24 (8.5%) in the Alpha period, 93 (32.9%) in the Delta period, and 103 (36.4%) in the Omicron period. Fever was the most common symptom in all groups, with no statistically significant differences (p = 0.25). In the Omicron period, respiratory and gastrointestinal symptoms decreased, and neurological symptoms increased significantly compared to other periods: [respiratory symptoms; nonvariant (65.1%) vs. Omicron (41.7%), (p = 0.024)], [gastrointestinal symptoms; Delta (41.9%) vs. Omicron (22.3%), (p = 0.018), [neurological symptoms; Delta (14.5%) vs. Omicron (31.1%), (p = 0.03]. Altered mental status and seizures were more common during the Omicron period compared to the pre-Omicron (nonvariant, Alpha, and Delta) period (p = 0.017 and p = 0.005, respectively). Although the main symptoms in children with COVID-19 were fever and respiratory symptoms, an increase in severe neurological manifestations was seen throughout the Omicron variant period.

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“…A study found that convulsions could be a sign of the Omicron variant in children with COVID-19 [83] . Another study on children with COVID-19 found that the Omicron variant is more likely to be associated with neurologic manifestations such as seizures compared with other COVID-19 virus variants [84] . However, there is still a lack of multicenter and forwardlooking research on the neurological complications caused by specific COVID-19 virus variants.…”

Section: Mechanisms Underlying the Neurologic Complications Of Covid-19mentioning

confidence: 99%

Neurological complications of coronavirus disease 2019 and the underlying mechanisms

Yang¹,

Mao²,

Guan³

et al. 2022

Adv Neuro

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The recent global pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although respiratory symptoms are the primary manifestation of the majority of COVID-19 patients, an increasing number of neurological symptoms and manifestations of COVID-19 have been observed. In this review, we detail the neurological complications of COVID-19, such as gustatory and olfactory dysfunctions, stroke, memory decline, muscle injury, and seizures. Furthermore, we introduce neural invasion mechanism underlying SARS-CoV-2 infection and, further, explain the occurrence of these complications. This review offers insights into the neurological signs and symptoms of COVID-19, which may help improve the prognosis of the infected patients.

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Provoked seizures and status epilepticus in a pediatric population with COVID‐19 disease

Cited by 30 publications

References 16 publications

Complex Febrile Seizures in Children with COVID-19 Infection

Complex Febrile Seizures in Children with COVID-19 Infection

The diversity in the clinical features of children hospitalized with COVID‐19 during the nonvariant, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variant periods of SARS CoV‐2: Caution for neurological symptoms in Omicron variant

Neurological complications of coronavirus disease 2019 and the underlying mechanisms

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