Provitamin A carotenoids from an engineered high-carotenoid maize are bioavailable and zeaxanthin does not compromise β-carotene absorption in poultry

Díaz-Gómez, Joana; Moreno, José María Villagrán; Angulo, E.; Sandmann, Gerhard; Zhu, Changfu; Capell, Teresa; Nogareda, C.

doi:10.1007/s11248-017-0029-y

Cited by 12 publications

(4 citation statements)

References 45 publications

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“…However, adding more color additives to poultry diets does not induce a change from white skin to yellow skin color, indicating that the coloring of the chicken skin is more complex. Furthermore, the presence of zeaxanthin in the feed might interfere with the absorption of b-carotene, as chickens fed on diets with low levels of zeaxanthin accumulated higher levels of retinol in the liver [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Variations in BCO2 Coding Sequence Causing a Difference in Carotenoid Concentration in the Skin of Chinese Indigenous Chicken

Wang

Gan

Luo

et al. 2023

Genes

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Carotenoid consumption decreases the risk of cancer, osteoporosis, or neurodegenerative diseases through interrupting the formation of free radicals. The deposition of carotenoids in chicken skin makes the skin color turn from white into yellow. The enzyme β-carotene oxygenase 2 (BCO2) plays a key role during the degradation process of carotenoids in skin. How the BCO2 affects the skin color of the chicken and whether it is the key factor that results in the phenotypic difference between yellow- and white-skin chickens are still unclear. In this research, the measurement of the concentration of carotenoids in chicken skin by HPLC showed that the carotenoid concentration in chickens with a yellow skin was significantly higher than that in white-skin chickens. Moreover, there were significant differences in BCO2 gene expression in the back skin between yellow- and white-skin chickens. Scanning the SNPs in BCO2 gene revealed a G/A mutation in exon 6 of the BCO2 gene in white and yellow skin chicken. Generally, one SNP c.890A>G was found to be associated with the chicken skin color and may be used as a genetic marker in breeding for yellow skin in Chinese indigenous chickens.

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Section: Discussionmentioning

confidence: 99%

Variations in BCO2 Coding Sequence Causing a Difference in Carotenoid Concentration in the Skin of Chinese Indigenous Chicken

Wang

Gan

Luo

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

“…However, adding more color additives to poultry diets does not induce a change from white skin to yellow skin color, indicating that coloring of the chicken skin is more complex. Furthermore, the presence of zeaxanthin in the feed might interfere with the absorption of b-carotene, as chickens fed on diets with low levels of zeaxanthin accumulated higher levels of retinol in the liver [21].…”

Section: Discussionmentioning

confidence: 99%

Variations in BCO2 Coding Sequence Causing a Difference in Carotenoid Concentration in the Skin of Chickens

Wang

Gan

Luo

et al. 2020

Preprint

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Background: Carotenoid consumption decreases the risk of cancer, osteoporosis, or neurodegenerative diseases through interrupting the formation of free radicals. Carotenoid-pigmented egg yolk, skin, legs, beak, comb, and feathers in broilers give consumers the impression that they are healthier than none-pigmented ones. Deposition of carotenoids in chicken skin makes the skin color turn from white into yellow. The enzyme β-carotene oxygenase 2 (BCO2) plays a key role during the degradation process of carotenoids in skin. How does the BCO2 affects the skin color of chicken, and whether it is the key factor resulted in the phenotypic difference between yellow- and white- skin chickens are still unclear. Three female chickens of the Guangxi Huang and Qingjiao Ma breed were slaughtered and used for carotenoid concentration and BCO2 expression level analysis. The carotenoid concentration in chicken skin was determined by HPLC. A total of 1054 DNA samples from seven different chicken breeds were genotyped and allele frequencies analysis.Results: In the present study, we measured the concentration of carotenoids in chicken skin showed that the carotenoid concentration in chicken with a yellow skin was significantly higher than that with white skin chicken. Then we analyzed the expression profile of BCO2 in different tissues and observed significant differences in gene expression in the back skin between yellow- and white- skin chicken. Scanning the SNPs in BCO2 gene, it revealed a G/A mutation in exon 6, which was confirmed by PCR-RFLP. Copy number variation (CNV) was also detected; the copy number in white yellow skin chicken was almost 2-fold of that than in yellow skin chicken. These results implied that the G/A mutation and CNV in chicken skin may play a key role in regulating the carotenoids degradation. Conclusions: Generally, reduced expression of the BCO2 gene due to lower CVNs may be responsible for the deposition of carotenoids and as a consequence a yellow skin color in yellow skin chicken. One SNP c.890A>G was found to be associated with the chicken skin color and may be used as a genetic marker in breeding for yellow skin in chicken in the future.

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“…Díaz‐Gómez et al. (2017a) stated that genetically modified maize having a higher concentration of lutein, β‐carotene and zeaxanthin showed similar pigmentation and growth performance to those fed commercial diet with synthetic colour additives. Another similar study reported that high carotenoid diet fed to broiler has enhanced pigmentation and protective immunity against infectious bursal disease (Nogareda et al., 2016).…”

Section: Health Benefits Of Carotenoids For Poultrymentioning

confidence: 99%

Health benefits of carotenoids and potential application in poultry industry: A review

Nabi

Arain

Rajput

et al. 2020

Animal Physiology Nutrition

122

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Carotenoids are one of the widespread and ubiquitous lipid-soluble pigments that produce a wide range of colours which are universally found in various plants, microalgae, bacteria and fungi. Recently, interest in using carotenoids as feed ingredients has increased markedly owing to their bioactive and health-promoting properties. In terms of applications, carotenoid-rich products are widely available in the form of food and feed additive, supplements and natural colourants. Carotenoids play a versatile biological role that contributes to therapeutic effects, including anticancer, immunomodulators, anti-inflammatory, antibacterial, antidiabetic and neuroprotective. Dietary supplementation of carotenoids not only improves the production performance and health of poultry birds, but also enhances the quality of egg and meat. Several studies have suggested that the supplementation of plant derived carotenoids revealed numerous health-promoting activities in poultry birds. Carotenoids reduce the oxidative stress in pre-hatched and post-hatched birds through different mechanisms, including quench free radicals, activating antioxidant enzymes and inhibiting the signalling pathways. Use of carotenoids in poultry feed as a part of nutrient that confers bird health and improve product quality. Carotenoids play a critical role for the pigmentation of egg yolk, skin, legs, beak, comb, feather and fat. Birds consumed carotenoid deficient diet resulting hues of their egg yolk or pale coloured skin. Therefore, uniform pigmentation generally indicates the health status and quality of the poultry products. This review aims to gather recent information regarding bioactive properties of carotenoids and highlight pharmaceutical and health beneficial effects of carotenoids for the poultry industry. Additionally, it explores the importance of carotenoids as alternative feed ingredients for poultry to boost the production performance and replace synthetic medicine and nutrients.

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Provitamin A carotenoids from an engineered high-carotenoid maize are bioavailable and zeaxanthin does not compromise β-carotene absorption in poultry

Cited by 12 publications

References 45 publications

Variations in BCO2 Coding Sequence Causing a Difference in Carotenoid Concentration in the Skin of Chinese Indigenous Chicken

Variations in BCO2 Coding Sequence Causing a Difference in Carotenoid Concentration in the Skin of Chinese Indigenous Chicken

Variations in BCO2 Coding Sequence Causing a Difference in Carotenoid Concentration in the Skin of Chickens

Health benefits of carotenoids and potential application in poultry industry: A review

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