Provisional Matrix Deposition in Hemostasis and Venous Insufficiency: Tissue Preconditioning for Nonhealing Venous Ulcers

Diabetic foot ulcers (DFU), one of the most serious complications of diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, the DFU microenvironment is rather complicated and characterized by hyperglycemia, ischemia, hypoxia, hyperinflammation, and persistent infection. However, the current clinical therapies for DFU are dissatisfactory, which drives researchers to turn attention to advanced nanotechnology to address DFU therapeutic bottlenecks. In the last decade, a large number of multifunctional nanosystems based on the microenvironment of DFU have been developed with positive effects in DFU therapy, forming a novel concept of “DFU nanomedicine”. However, a systematic overview of DFU nanomedicine is still unavailable in the literature. This review summarizes the microenvironmental characteristics of DFU, presents the main progress of wound healing, and summaries the state‐of‐the‐art therapeutic strategies for DFU. Furthermore, the main challenges and future perspectives in this field are discussed and prospected, aiming to fuel and foster the development of DFU nanomedicines successfully.

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“…(1) Unrelated to massive blood loss, some wounds are accompanied by slight blood loss; hemostasis is initiated immediately after trauma; [ 33 ]…”

Section: Dfu Wounds and The Microenvironment Of Perturbed Wound Healingmentioning

confidence: 99%

“…(1) Unrelated to massive blood loss, some wounds are accompanied by slight blood loss; hemostasis is initiated immediately after trauma; [33] (2) Wounds mostly manifest as ulceration and accumulation of necrotic debris at the edges. [31] Inflammation Transient Chronic and persistent…”

Section: Dfu Wounds and The Microenvironment Of Perturbed Wound Healingmentioning

confidence: 99%

Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Huang

Yang

et al. 2022

Advanced Science

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“…Although this phase is crucial in removing invading pathogens, dead cells, and debris, the released mediators during this phase are also important for proliferation of keratinocytes, fibroblasts, and epithelial cells. As new tissues develop, the environment becomes less pro‐inflammatory and more anti‐inflammatory which skews the monocyte differentiation away from the pro‐inflammatory (M1) towards the anti‐inflammatory (M2) macrophage phenotype that promotes angiogenesis (Koh & DiPietro, 2011; Parker et al ., 2013; Sinno & Prakash, 2013; Kumar et al ., 2015; Thiruvoth et al ., 2015; Landén et al ., 2016; Young et al ., 2016; Werner & Grose, 2017; Larouche et al ., 2018).…”

Section: The Effect Of Es Products On the Inflammation Phase Of Wound Healingmentioning

confidence: 99%

“…However, in contrast to the primary sub‐phase, the secondary phase eventually leads to the formation of insoluble fibrin rather than platelet aggregation. The fibrin mesh and platelet aggregate from a complete clot that prevents further blood loss, provides a barrier against invading microbes, serves as matrix for invading cells and functions as a reservoir of growth factors important for the healing process (Koh & DiPietro, 2011; Parker et al ., 2013; Sinno & Prakash, 2013; Kumar et al ., 2015; Thiruvoth et al ., 2015; Landén et al ., 2016; Nandi & Brown, 2016; Young et al ., 2016; Werner & Grose, 2017; Larouche et al ., 2018).…”

Section: The Effect Of Es Products On the Haemostasis Phase Of Wound ...mentioning

confidence: 99%

“…Wound healing can be divided into four overlapping physiological phases of repair: Haemostasis, inflammation, proliferation, and remodelling phases (Koh & DiPietro, 2011; Cazander et al ., 2013; Parker et al ., 2013; Sinno & Prakash, 2013; Kumar et al ., 2015; Thiruvoth et al ., 2015; Landén et al ., 2016; Nigam & Morgan, 2016; Young et al ., 2016; Werner & Grose, 2017; Larouche et al ., 2018). These four phases usually progress smoothly, however, in some cases healing may be trapped in one of these phases, usually the inflammatory phase, leading to exacerbated scarring and neoplastic progression (Zhao et al ., 2016).…”

Section: Introductionmentioning

confidence: 99%

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The effect of Lucilia sericata larval excretion/secretion (ES) products on cellular responses in wound healing

Gazi

Taylan-Özkan

Mumcuoglu³

2020

Medical Vet Entomology

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Chronic wounds are still regarded as a serious public health concern, which are on the increase mainly due to the changes in life styles and aging of the human population. There are different types of chronic wounds, each of which requires slightly different treatment strategies. Nevertheless, wound bed preparation is included in treatment of all types of chronic wounds and involves tissue debridement, inflammation, and infection control, as well as moisture balance and epithelial edge advancement. Maggot therapy (MT) is a form of biological debridement which involves the application of live medical grade Lucilia sericata (Meigen, 1826) (Diptera: Calliphoridae) larvae. Whereas it was initially thought to act mainly through debridement, today MT is known to influence all four overlapping physiological phases of wound repair: homeostasis, inflammation, proliferation, and remodelling/maturing. During MT, medical‐grade larvae are applied either freely or enclosed in tea‐bag like devices (biobag) inside the wounds, which suggests that larva excretion/secretion (ES) products can facilitate the healing processes directly without the need of direct contact with the larvae. This review summarizes the relevant literature on ES‐mediated effects on the cellular responses involved in wound healing.

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Ulcus cruris venosum

Weber

Deinsberger

2022

hautnah

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ZusammenfassungDas Ulcus cruris venosum entsteht im Rahmen einer fortgeschrittenen chronisch-venösen Insuffizienz und stellt die häufigste Entität chronischer Ulzerationen der unteren Extremität dar. Da die Prävalenz im Alter deutlich ansteigt, stellen venöse Ulzera in einer alternden Gesellschaft ein zunehmend relevantes Gesundheitsproblem dar, welches mit einer signifikanten Morbidität und einer hohen sozioökonomischen Belastung verbunden ist. Die Behandlung stellt aufgrund der niedrigen Heilungsrate, der häufigen Chronifizierung und der hohen Rezidivrate eine Herausforderung dar. Die Therapie umfasst in der Regel mehrere Modalitäten, wobei stets die Reduktion der venösen Hypertension in den zuführenden Gefäßen im Vordergrund steht. Bezüglich konservativer Therapieoptionen stehen die Kompressionstherapie, die pharmakologische Therapie sowie ergänzend die lokale Wundpflege zur Verfügung. Im Rahmen der kausalen, invasiven Therapie der dem Ulkus zugrunde liegenden Varkositas finden vor allem endoluminal-ablative Verfahren, die offene chirurgische Sanierung und die Schaumsklerotherapie ihre Anwendung. Neben einer Optimierung der invasiven Verfahren, liegt vor allem in der Entwicklung adjuvanter Therapiemodalitäten noch großes Potenzial.

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Provisional Matrix Deposition in Hemostasis and Venous Insufficiency: Tissue Preconditioning for Nonhealing Venous Ulcers

Cited by 5 publications

References 138 publications

Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

The effect of Lucilia sericata larval excretion/secretion (ES) products on cellular responses in wound healing

Ulcus cruris venosum

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