Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease globally.Despite the increased demand placed on healthcare systems, little attention has been given to the 2 design and implementation of efficient and effective models of care for patients with NAFLD. In many healthcare settings, no formal pathways exist and where pathways are in place, they are often not standardized according to good practices. We systematically searched the peer-reviewed literature with the aim of identifying published examples of comprehensive models of care that answered four key questions: what services are provided; where are they provided; who is offering them; and how are they coordinated and integrated within healthcare systems. We identified seven models of care and synthesized the findings into eight recommendations nested within the 'what, where, who and how' of care models. These recommendations, aimed at policymakers and practitioners designing and implementing models of care, can help to address the increasing need for the provision of good practice care for patients with NAFLD.