Protozoan Intestinal Parasitic Infection in Patients with Hematological Malignancies

Łanocha, Aleksandra; Łanocha-Arendarczyk, Natalia; Wilczyńska, Dominika; Zdziarska, Barbara; Kosik-Bogacka, Danuta

doi:10.3390/jcm11102847

Cited by 10 publications

(7 citation statements)

References 43 publications

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“…and Blastocystis spp. was found to be significantly higher in patients with hematological malignancies, especially large B-cell lymphoma and plasma cell myeloma, than in healthy controls [79].…”

Section: Parasitic Protozoans In Patients Immunocompromised or With P...mentioning

confidence: 82%

Protozoan Infections Acquired from Food or Drinking Water: An Update

Rossi,

Amadoro,

Santonicola

et al. 2024

Preprint

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This review summarizes the most recent developments of research on protozoan parasite infections ac-quired through food and drinking water and is aimed at gathering updated knowledge on the risk factors, illnesses caused, and measures for prevention. Reports included dated from 2019 to the present and regarded recent outbreaks and cases of severe infec-tions, prevalence in different population segments and food handlers, and occurrence in food and drinking water. Cryptosporidium spp., Entamoeba histolytica, Giardia intestinalis, Trypanosoma cruzi and Toxoplasma gondii were the microorganisms most frequently involved in large outbreaks and/or severe infections, while Cyclospora cayetanensis was most frequently involved in single case reports. Cystoisospora belli was implied in severe infections in immunocompromised patients, while Blastocystis homi-nis, Sarcocystis spp., Dientamoeba fragilis, Endolimax nana and Pentatrichomonas hominis appeared to be less relevant for number of symptomatic infections and pathogenic potential. A progressive improvement in surveillance of protozoan infections and infection sources was highlighted, especially in developed countries. The apparent increase in cases was concomitant with the implementa-tion of reporting systems and the application of molecular diagnostic methods that represent valuable in-struments for establishing epidemiological links and preventing or limiting outbreaks. The pathogenic role and sources of infection should be better elucidated for some species.

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Section: Parasitic Protozoans In Patients Immunocompromised or With P...mentioning

confidence: 82%

Protozoan Infections Acquired from Food or Drinking Water: An Update

Rossi,

Amadoro,

Santonicola

et al. 2024

Preprint

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“…[ 23 ] The reduced CD4 lymphocyte count in peripheral blood of the other two (2/4, 50.0%) patients suffering from hematologic malignancies favored parasitic infestation with intestinal parasitic infections. [ 24 25 26 ]…”

Section: Discussionmentioning

confidence: 99%

The spectrum of parasitic infections with emphasis on the clinico-epidemiological characteristics and risk factors among immunocompromised and immunocompetent patients at a university hospital in Northern India

Kar,

Singh,

Tejan

et al. 2024

Journal of Family Medicine and Primary Care

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Introduction: Intestinal parasitic infections pose a substantial threat to public health and are a huge burden to the economic development of a developing country. We aimed to identify the spectrum of intestinal parasitic infections with an emphasis on demographic and clinical characteristics observed among immunocompromised and immunocompetent patients. Materials and Methods: This observational study was performed in the Parasitology section of the Department of Microbiology from January 2022 to July 2022. A total of 2628 stool samples were obtained from patients presenting with chief complaints of abdominal pain, distension, vomiting, and foul-smelling feces. All the clinical and diagnostic data of the patients enrolled in the above-mentioned period were extracted from the ward files, hospital electronic records, and laboratory registers. Result: A total of 2628 stool samples were sent to the Parasitology section of the Department of Microbiology. Out of the above-mentioned samples, 70 (70/2628, 2.66%) samples yielded gastrointestinal parasites on microscopic examination. The mean age of the patients included in our cohort study was 32.53 ± 16.21 years with a male predominance of 72.86% (51/70, 72.86%). The most common gastrointestinal parasite identified from stool samples was Giardia lamblia (61/70, 87.14%). All cases of opportunistic gastrointestinal infection caused by Cryptosporidium spp. (4/70, 5.71%) in our study cohort were found to infest the immunocompromised patients. Conclusion: This study determines the spectrum of intestinal parasitic infections among the immunocompromised and immunocompetent individuals and guides physicians in starting appropriate anti-parasitic treatment along with the instillation of strict hand hygiene techniques.

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“…ranged from 2 to 21% in patients with hematological malignancies. 17 , 18 , 19 , 20 In patients undergoing autologous or allogeneic stem cell transplant therapy, intestinal parasite infections, including Blastocystis sp. were scarcely reported.…”

Section: Discussionmentioning

confidence: 99%

Blastocystis sp.—An emerging cause of diarrhea post stem cell transplantation

Radhwi

Almohammadi

Al-Marzouki

et al. 2023

Clinical Case Reports

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Key Clinical Message Protozoans are endemic in the Middle East and diarrhea workup post stem cell transplant should always include stool examination for ova and parasites. Abstract We present a case of Blastocystis sp. infection in a multiple myeloma patient who developed diarrhea on day five of post‐autologous stem cell transplantation. Diarrhea is a major complication and a potential cause of mortality in this population. Testing for endemic protozoan is recommended.

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Protozoan Intestinal Parasitic Infection in Patients with Hematological Malignancies

Cited by 10 publications

References 43 publications

Protozoan Infections Acquired from Food or Drinking Water: An Update

Protozoan Infections Acquired from Food or Drinking Water: An Update

The spectrum of parasitic infections with emphasis on the clinico-epidemiological characteristics and risk factors among immunocompromised and immunocompetent patients at a university hospital in Northern India

Blastocystis sp.—An emerging cause of diarrhea post stem cell transplantation

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