Proton two‐dimensional chemical shift imaging for evaluation of prostate cancer: External surface coil vs. endorectal surface coil

Kaji, Yuichi; Wada, Akihiko; Imaoka, Izumi; Matsuo, Michimasa; Terachi, Toshiro; Kobashi, Yoichiro; Sugimura, Kazuro; Fujii, Masahiko; Maruyama, Katsuya; Takizawa, Osamu

doi:10.1002/jmri.10204

Cited by 34 publications

(24 citation statements)

References 14 publications

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“…Also, if the concentration of metabolites is low these are not detected or sometimes artifacts mask observation of metabolites. Table 2 presents the metabolite ratio values reported by various researchers [83,89,[92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108]135]. A correlation between metabolite ratio and the Gleason grade has also been reported [98,109].…”

Section: Magnetic Resonance Spectroscopy and Imagingmentioning

confidence: 87%

Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective

Jagannathan

Kumar

et al. 2008

Magn Reson Mater Phy

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The challenges in detection, localization, and staging of prostate cancer have prompted the investigation of the role of various magnetic resonance (MR) methodologies in a large cohort of men prior to biopsy. The identification of suspicious areas of malignancy was carried out using magnetic resonance imaging (MRI), magnetic resonance spectroscopic imaging (MRSI) and diffusion-weighted imaging (DWI). Our data shows that apparent diffusion coefficient (ADC) may be a reliable marker to differentiate normal, benign, and malignant prostate tissues similar to the metabolite ratio. Also, the combined use of MRSI and DWI improves the diagnosis of prostate cancer. In this review, we present our experience on the use of MRI, MRSI and DWI methods in the assessment of prostate cancer in Indian men. Further, analysis of the comparison of the ADC and the metabolite ratio values reported in the literature across various patient populations are presented.

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Section: Magnetic Resonance Spectroscopy and Imagingmentioning

confidence: 87%

Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective

Jagannathan

Kumar

et al. 2008

Magn Reson Mater Phy

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“…In our study, a effective voxel size of approximately 12×12×27 mm 3 (approximately 3.89 cm 3 ) is resulting. The 2D MR spectroscopic imaging sequence used by Kaji et al [17] with a standard spine array coil yielded a voxel size of 1 cm 3 . However, data were also interpolated (to a 32×32 matrix) and effective and nominal voxel sizes were not distinguished.…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

“…For clinical purposes, however, 3D multivoxel techniques covering the whole prostate are mandatory for the assessment of tumour localization and extent. Recently, Kaji et al reported that 2D MR spectroscopic imaging has comparable detection accuracy to the endorectal coil when an external surface coil is used [17]. However, for accurate diagnosis, total prostate coverage is required.…”

Section: Introductionmentioning

confidence: 96%

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3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5�T in clinical routine: a feasibility study

et al. 2004

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The objective of this study was to demonstrate the feasibility of 3D proton MR spectroscopic imaging (MRSI) of the prostate using a standard spine instead of a dedicated endorectal coil at 1.5 T. Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate hyperplasia) were examined. MRI and MRSI were conducted with commercial array surface coils at 1.5 T. Ratios of choline (Cho), creatine (Cr) and citrate (Ci) were calculated for tumour, central and peripheral zone retrospectively, based on axial T2 weighed MR images and histology reports. Prostate cancer was characterized by significantly elevated (Cho+Cr)/Ci ratio compared with non-tumourous prostate tissue. The quality of all proton MR spectra was considered to be good or acceptable in 17/28 patients (61%) and poor in 11/28 (39%) examinations. In 20/25 patients with proven malignancy (80%), MRSI was considered to be helpful for the detection of prostate cancer. In 4/25 patients with proven malignancy (16%) who underwent seed implantation, radiotherapy or hormone deprivation before MR examination spectroscopy was of poor and non-diagnostic quality. MRSI of the prostate is feasible within clinical routine using the spine array surface coil at 1.5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils.

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“…Essentially, CSI detects in vivo the tissue distributions of metabolites (10). CSI has been utilized to monitor biochemical and metabolic phenotypic changes noninvasively in animals and humans (10,(15)(16)(17). CSI has also been utilized to detect intracranial mobile lipids in the rat brain utilizing an ultrashort echo time (TE) (18).…”

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confidence: 99%

In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGFα/c-myc transgenic mouse model

Griffitts

Tesiram

Reid

et al. 2009

Journal of Lipid Research

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Current detection methods (computed tomography, ultrasound, and MRI) for hepatocarcinogenesis in humans rely on visual confirmation of neoplastic formations. A more effective early detection method is needed. Using in vivo magnetic resonance spectroscopy (MRS), we show that alterations in the integral ratios of the bis-allyl to vinyl hydrogen protons in unsaturated lipid fatty acyl groups correlate with the development of neoplastic formations in vivo in a TGFa/c-myc mouse hepatocellular carcinoma (HCC) model. HPLC analysis of the TGFa/c-myc mice liver tissue revealed a significant increase in the amount of oleic acid, along with alterations in linoleic and g-linolenic acids, as compared with control CD1 mice. Electrospray ionization tandem mass spectrometry analysis indicated a significant increase in the abundance of specific glycerol phosphatidylcholine (GPCho) lipids containing palmitic and oleic acids between control CD1 and TGFa/c-myc mice liver tissue extracts. Western blot analysis of the mice liver tissue indicates alterations in the desaturase enzyme stearoyl CoA desaturase (SCD)1, responsible for palmitic and oleic acid formation. Microarray analysis detected alterations in several genes involved with fatty acid metabolism, particularly SCD2, in transgenic mouse liver tissue. In correlation with the HPLC, mass spectrometry, Western blot, and microarray analyses, we are able to confirm the ability of in vivo MRS to detect precancerous lesions in the mouse liver before visual neoplastic formations were detectable by MRI. Hepatocellular carcinoma (HCC) is one of the most deadly forms of cancer in the world. The World Health Organization reports that liver cancer is the third highest cause of death from cancer, with HCC being predominantly observed in Asian and African countries (1). There are many known causes of HCC, including hepatitis B and C, cirrhosis, and aflatoxin exposure. The techniques currently used for diagnosis of liver cancer rely on imaging modalities (MRI, computed tomography, and ultrasound) that, at the highest sensitivity, are able to detect evidence of neoplasia when there is a formation of at least 1 mm. Image confirmation of a neoplasm this size usually only occurs at a later stage in cancer development when therapy treatments are not as effective. Therefore, the prognosis for a patient when they have visual evidence of neoplasia is poor. Additionally, neoplasms at the lower range of imaging detection are often unverifiable without biopsy. There is a need, therefore, to develop a method that can detect neoplastic formations at an earlier stage than those now in use.The efficacy of utilizing MRI, which mainly detects only protons from water hydrogens, for hepatic tumor detection and the measurement of tumor volumetric growth has been established previously (2, 3). We have utilized MRI in this study for visual confirmation of neoplastic tissue formations in the TGFa/c-myc mouse liver tumor model. In addition to the MRI visible liver changes, there have been several metabolic ...

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Proton two‐dimensional chemical shift imaging for evaluation of prostate cancer: External surface coil vs. endorectal surface coil

Cited by 34 publications

References 14 publications

Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective

Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective

3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5�T in clinical routine: a feasibility study

In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGFα/c-myc transgenic mouse model

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