Proton spectroscopy of human brain: Effects of age and sex

Charles, H. Cecil; Lazeyras, François; Krishnan, K. Ranga Rama; Boyko, Orest B.; Patterson, Linda; Doraiswamy, P. Murali; McDonald, William M.

doi:10.1016/0278-5846(94)90125-2

Cited by 99 publications

(73 citation statements)

References 14 publications

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“…NAA, like Glu, is also localized primarily in neurons and is considered to be a putative neuronal marker [27,42]. Our finding of reduced NAA in the motor cortex region with normal aging is consistent with previous MRS studies that demonstrated decreased NAA with age in certain regions of the normal brain [4,6,35]. The present study further showed a strong positive correlation between Glu and NAA concentration, which is consistent with the idea that Glu is localized primarily in neurons and that neuronal integrity is vulnerable in the aging process.…”

Section: Discussionsupporting

confidence: 91%

“…glial versus neuronal), and it is not clear to what extent Cr and Cho represent glial compartments. In contrast, no age-related NAA and Glu changes were detected in the COR region, consistent with other 1 H MRS studies that also report stable NAA with aging in white matter [5,6,31,33]. In this context, it is interesting to note that m-Ins concentration decreased in the MC region and increased in the COR region in older subjects compared to the younger group (m-Ins is used predominantly as glial marker in the 1 H MRS literature [3]).…”

Section: Discussionsupporting

confidence: 88%

“…Several 1 H MRS studies demonstrated that compared to younger populations, older subjects have reduced cerebral N-acetyl aspartate (NAA), a putative neuronal marker [27,42], suggesting neuronal loss or deficit in neuronal metabolism [4,6,35]. Since Glu is also located primarily in neurons [28,29] and its concentration in the brain most likely reflects neuronal integrity, it should also decrease with age, similar to the NAA.…”

Section: Introductionmentioning

confidence: 99%

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Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T

Kaiser

Schuff

Cashdollar

et al. 2005

Neurobiology of Aging

217

150

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Proton magnetic resonance spectroscopy was performed at 4 T to determine effects of age, region and gender on glutamate and glutamine in the normal human brain. Furthermore, glutamate and glutamine alterations with age were tested for correlations with other cerebral metabolites. Two 8 cm 3 volumes were selected in corona radiata and mesial motor cortex in normal subjects (N = 24) between 24 and 68 years old. Older subjects had lower glutamate concentration in the motor cortex compared to younger subjects (p < 0.001). In corona radiata, older subjects demonstrated a trend in higher glutamine compared to younger subjects (p = 0.05). Glutamate in the motor cortex was positively correlated with glutamine, N-acetyl aspartate and creatine. Reduced glutamate and Nacetyl aspartate in the motor cortex is consistent with neuronal loss/shrinkage with age. In conclusion, different patterns in association with normal aging in these brain regions were detected in this study.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T

Kaiser

Schuff

Cashdollar

et al. 2005

Neurobiology of Aging

217

150

View full text Add to dashboard Cite

show abstract

“…Elevations in white matter Cho/Cre have been observed in children with mild developmental delays at the age of 2 years, presumably as a result of under-myelination (Filippi et al, 2002). Charles et al found that the choline, creatine, and NAA levels were all lower in the gray matter of older subjects than younger subjects, but found no differences in white matter between older and younger subjects (Charles et al, 1994).…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 97%

Advances in white matter imaging: A review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging

Wozniak

Lim

2006

Neuroscience & Biobehavioral Reviews

240

178

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Several newer magnetic resonance imaging (MRI) techniques are increasingly being applied to the study of white matter development and pathology across the lifespan. These techniques go beyond traditional macrostructural volumetric methods and provide valuable information about underlying tissue integrity and organization at the microstructural and biochemical levels. We first provide an overview of white matter development and discuss the role of white matter and myelin in cognitive function. We also review available studies of development that have employed traditional volumetric measures. Then, we discuss the contributions of four newer imaging paradigms to our understanding of brain development and aging. These paradigms are Diffusion Tensor Imaging (DTI), Magnetization Transfer Imaging (MTI), T2-Relaxography, and Magnetic Resonance Spectroscopy (MRS). Studies examining brain development during childhood and adulthood as well as studies of the effects of aging are discussed.

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“…The effect of aging on the content of the key brain metabolite NAA has been the subject of recent proton magnetic resonance spectroscopy studies in brain research. The content of NAA was generally higher in the brain of young experimental animals and healthy young volunteers [25] and low NAA concentration was found in the cortex of older volunteers [26]. However there are many opposite results, where the brain concentration of N-acetyl compounds was not reduced, in the elderly healthy control group [27].…”

Section: Discussionmentioning

confidence: 97%