Middle-aged rat hippocampus and some early changes accompanying aging

Gaspárová, Zdenka; Janega, Pavol; Prónayová, Naďa; Liptaj, Tibor

doi:10.2478/s11535-012-0074-8

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Age‐related changes in hippocampus‐dependent function and hippocampal morphology have been reported in numerous articles (Rapp and Amaral, ; Geinisman et al, ; Rapp and Gallagher, ; Rasmussen et al, ; Porter and Landfield, ; Gaserova et al, ; Ojo et al, ). For a long time, neuronal death in the hippocampus was regarded as the principal contributor to hippocampus‐dependent functional impairments during aging.…”

Section: Introductionmentioning

confidence: 90%

Stereological Investigation of the Age‐Related Changes of the Myelinated Fibers in the Hippocampus of Male Rats

Lü

Yang

Chen

et al. 2014

The Anatomical Record

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The decline of hippocampus-dependent learning and memory during normal aging is not associated with neuron death and synapse loss. Until now, age-related changes in the myelinated fibers of the hippocampus have not been investigated. Therefore, in this study, the myelinated fibers in the hippocampi of young (6 months), middle-aged (18 months), and old-aged (28 months) male Sprague-Dawley rats were studied with transmission electron microscope and stereological methods, following spatial learning tests in a Morris water maze. The results showed that hippocampus-dependent spatial learning was impaired in old-aged rats but that the total volume, length, and mean diameter of the myelinated fibers in the hippocampus, as well as the hippocampal volume, remained constant during the normal aging process. Our results suggest that the age-related decline in hippocampusdependent spatial learning is not attributable to myelinated fiber changes in the hippocampus and that other, undetermined factors are responsible.

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