Proton radiation therapy (prt) for pediatric optic pathway gliomas: comparison with 3d planned conventional photons and a standard photon technique

Fuß, Martin; Hug, Eugen B.; Schaefer, Rosemary A.; Nevinny-Stickel, Meinhard; Miller, Daniel W.; Slater, James M.; Slater, Jerry D.

doi:10.1016/s0360-3016(99)00337-5

Cited by 139 publications

(71 citation statements)

References 32 publications

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“…This is seen in 65-85% of patients with tumors of the optic nerves. 18 When tumor is confined to the optic nerves, CT imaging demonstrates well-demarcated enlargement of the nerve, often with a tortuous or kinked appearance of the nerves. 15,65 Tumors of the chiasm exhibit a variety of appearances, from an enlargement of the chiasm to a suprasellar mass that may calcify.…”

Section: Diagnostic Imagingmentioning

confidence: 99%

“…On T2-weighted images, the inverse is seen. Furthermore, patients with NF1 are more likely to demonstrate glioma extension along the optic tracts into the lateral geniculate ganglia and temporal lobes 18,73 as well as infiltrating lesions. 25 Hydrocephalus may be apparent for large tumors that obstruct CSF outflow (Figs.…”

Section: Diagnostic Imagingmentioning

confidence: 99%

“…17,76 In addition, new techniques of delivering radiation, including stereotactic radiosurgery and proton beam radiotherapy, have been developed. 18 Stereotactic conformal radiotherapy has been associated with a 79% 5-year survival rate without the cognitive or endocrine disturbances associated with traditional external-beam radiation therapy. 11,51,65 Proton beam therapy is an attractive option for radiation therapy, as it is able to provide high doses of radiation to the lesion with sharp fall-off of energy within millimeters of the treatment area.…”

Section: Radiotherapy For Opgsmentioning

confidence: 99%

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Optic pathway gliomas: a review

Binning

Liu

Kestle

et al. 2007

FOC

169

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✓Optic pathway gliomas represent approximately 3–5% of childhood intracranial tumors. They usually occur in children during the first decade of life and are seen in 11–30% of patients with neurofibromatosis Type 1 (NF1). Although these tumors are typically low-grade gliomas, the clinical course and natural history are highly variable, making treatment paradigms difficult. Overall, however, they are often indolent tumors that can be observed over time for progression without initial treatment, especially in patients with NF1. Chemotherapy is the first-line treatment for progressive tumors, and radiation therapy is reserved for patients with progressive disease who are older than 5–7 years. Surgery is reserved for large tumors causing mass effect or hydrocephalus and tumors confined to the orbit or unilateral optic nerve.

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Section: Diagnostic Imagingmentioning

confidence: 99%

Section: Diagnostic Imagingmentioning

confidence: 99%

Section: Radiotherapy For Opgsmentioning

confidence: 99%

See 1 more Smart Citation

Optic pathway gliomas: a review

Binning

Liu

Kestle

et al. 2007

FOC

169

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“…With prices exceeding $100 million per unit, the cost-benefit ratio remains to be accurately described; efficacy data are still maturing. Diseases for which benefits have been seen with charged particles include uveal melanomas, 51 optic pathway gliomas, 52 skull-based tumors, 53 pituitary adenomas, 54 acoustic neuromas, 55 nasopharynx and paranasal sinuses, 56,57 spinal cord tumors, 58,59 prostate cancer, 60,61 lung cancer, [62][63][64][65] gastrointestinal malignancies, [66][67][68] and pediatric cancers. 69 …”

Section: Charged Particlesmentioning

confidence: 99%

Radiation Techniques in Neuro-Oncology

Khuntia

Mehta

2009

Neurotherapeutics

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Summary: Radiation therapy plays a critical role in the management of tumors of the brain. A variety of radiotherapy techniques have been used to treat these tumors. This review describes both classic and more recent and advanced techniques available to manage these tumors. Included is a discussion of standard two-and three-dimensional radiation, as well as intensity-modulated radiotherapy, image-guided radiation therapy, stereotactic radiosurgery, and heavy particles.

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“…This risk is especially an issue for pediatric neuro-oncology [71]. With regard to proton therapy for pediatric cranial tumors, early treatment-related morbidity associated with proton therapy is low and decreased long-term toxicity in the maturing child is expected [43,75]. A comparative analysis of the incidence of secondary cancer after therapy for Hodgkin's disease with photon or proton radiation indicated that IMRT has little or no improvement over conventional treatments.…”

Section: Proton and Helium Radiation Therapymentioning

confidence: 99%

Late effects from hadron therapy

Blakely

Chang

2004

Radiotherapy and Oncology

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Successful cancer patient survival and local tumor control from hadron radiotherapy warrant a discussion of potential secondary late effects from the radiation. The study of late-appearing clinical effects from particle beams of protons, carbon, or heavier ions is a relatively new field with few data. However, new clinical information is available from pioneer hadron radiotherapy programs in the USA, Japan, Germany and Switzerland. This paper will review available data on late tissue effects from particle radiation exposures, and discuss its importance to the future of hadron therapy.Potential late radiation effects are associated with irradiated normal tissue volumes at risk that in many cases can be reduced with hadron therapy. However, normal tissues present within hadron treatment volumes can demonstrate enhanced responses compared to conventional modes of therapy. Late endpoints of concern include induction of secondary cancers, cataract, fibrosis, neurodegeneration, vascular damage, and immunological, endocrine and hereditary effects. Low-dose tissue effects at tumor margins need further study, and there is need for more acute molecular studies underlying late effects of hadron therapy.2

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Proton radiation therapy (prt) for pediatric optic pathway gliomas: comparison with 3d planned conventional photons and a standard photon technique

Cited by 139 publications

References 32 publications

Optic pathway gliomas: a review

Optic pathway gliomas: a review

Radiation Techniques in Neuro-Oncology

Late effects from hadron therapy

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