Optic pathway gliomas: a review

Binning, Mandy J.; Liu, James K.; Kestle, John R. W.; Brockmeyer, Douglas L.; Walker, Marion L.

doi:10.3171/foc-07/11/e2

Cited by 169 publications

(68 citation statements)

References 83 publications

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“…The literature has primarily focused on pediatric patients with gliomas of the optic pathway, which represent approximately 3-5% of all pediatric intracranial tumors, with the majority of cases characterized as pilocytic astrocytoma [1]. A subtype of gliomas in this region, termed optic chiasmatic-hypothalamic gliomas, simultaneously involve the optic chiasm and the hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

Gliomas in the Sellar Turcica Region: A Retrospective Study Including Adult Cases and Comparison with Craniopharyngioma

Deng¹,

Li²,

Guan³

et al. 2014

Eur Neurol

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Purpose: Previous studies of sellar gliomas have been confined to pediatric optic pilocytic gliomas. The present study aimed to analyze the features of sellar gliomas involving both pediatric and adult patients with various pathologies and to compare them with craniopharyngiomas to better differentiate the diagnosis. Methods: Twenty-seven sellar gliomas were retrospectively examined regarding their demographics, pathologies, clinical and imaging presentations, surgeries and postoperative complications. Thirty craniopharyngiomas from the same period and 880 gliomas of the most common pathologies from 2008-2014 were included for comparisons. Results: In total, 55.6% of the sellar gliomas were adult cases. The pathology included pilocytic astrocytoma, ganglioglioma, diffuse astrocytoma, pilomyxoid astrocytoma, oligoastrocytoma, and glioblastoma. Compared with craniopharygiomas, sellar gliomas presented with a significantly lower ratio of visual disturbances, growth hormone deficiencies, lesion cystic changes, and calcification. Sellar gliomas had significantly greater effects on the patients' mentality and anatomical brain stem involvement. Total resections were achieved in 11 patients, which were significantly lower compared with craniopharyngiomas. Conclusions: Sellar gliomas affect both pediatric and adult patients with pathological changes extending beyond pilocytic astrocytomas. They have diverse clinical manifestations and imaging presentations. Differences exist regarding several aspects between sellar gliomas and craniopharyngiomas, which may facilitate a differential diagnosis.

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Section: Introductionmentioning

confidence: 99%

Gliomas in the Sellar Turcica Region: A Retrospective Study Including Adult Cases and Comparison with Craniopharyngioma

Deng¹,

Li²,

Guan³

et al. 2014

Eur Neurol

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“…The history of these tumors is variable based on histology, presence, or absence of NF1, and also individual differences in each patient [31]. Treatment can range from observation in asymptomatic patients with smaller tumors to chemotherapy, radiation therapy, and surgery.…”

Section: Discussionmentioning

confidence: 98%

“…Usually chemotherapy is the first-line treatment for progressive tumors, and radiation therapy is reserved for patients with progressive disease who are older than 5-7 years. Large tumors with mass effect or hydrocephalus may require surgery [31]. Because PMA generally exhibits more aggressive biological behavior, physicians have been inclined to implement adjuvant therapy earlier in the course of treatment [32].…”

Section: Discussionmentioning

confidence: 99%

High accuracy of arterial spin labeling perfusion imaging in differentiation of pilomyxoid from pilocytic astrocytoma

et al. 2015

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“…We utilized 3-D tractography of the optic nerves to evaluate tumor involvement, which correlated with the intraoperative findings. Gliomas are among the more common supratentorial pediatric primary brain tumors and have a propensity to occur centrally, at a suprasellar or chiasmatic location, as hypothalamic or optic gliomas [14]. Optic nerve pathway gliomas are rare and often unresectable tumors in children [15].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Diffusion Tensor Imaging of the Optic Nerves to Guide Treatment of Pediatric Suprasellar Tumors

et al. 2009

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Background/Aims: As a preoperative planning tool, conventional magnetic resonance (MR) imaging may have limited value in differentiating tumors from white matter tracts. MR diffusion tensor imaging (MRDTI) has become a useful tool for evaluating white matter tracts in relation to surrounding structures and has been used in surgical planning for brain tumors involving white matter. We investigated the use of DTI of the optic nerves in surgical planning for pediatric suprasellar tumors. Methods: We present findings in 10 pediatric control patients and 2 cases of pediatric suprasellar tumors in which a routine 6-direction DTI of the brain was performed at 3 T. Postprocessing permitted the study of the diffusion tensor parameters, as well as the tractography, of the optic nerves. Results: The control patients demonstrated the optimization of the technique and permitted the quantitation of fractional anisotropy and apparent diffusion coefficient values. The tumor cases demonstrated the utility of optic nerve DTI to differentiate between optic nerves and suprasellar/chiasmatic brain tumors. Conclusions: A routine 6-direction DTI of the pediatric brain at 3 T permits a detailed DTI study of the optic nerves. Optic nerve tractography can be used to aid in the evaluation and treatment of pediatric brain tumors in the area of the optic chiasm.

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Optic pathway gliomas: a review

Cited by 169 publications

References 83 publications

Gliomas in the Sellar Turcica Region: A Retrospective Study Including Adult Cases and Comparison with Craniopharyngioma

Gliomas in the Sellar Turcica Region: A Retrospective Study Including Adult Cases and Comparison with Craniopharyngioma

High accuracy of arterial spin labeling perfusion imaging in differentiation of pilomyxoid from pilocytic astrocytoma

Magnetic Resonance Diffusion Tensor Imaging of the Optic Nerves to Guide Treatment of Pediatric Suprasellar Tumors

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