Proton beam radiotherapy: a specialized treatment alternative

Thornton, Allan F.; Fitzek, Markus M.; Klein, Susan; Dickey, Edward; Sullivan, Molly; O’Ryan-Blair, Avril; Schreuder, Niek; Allgower, Christopher; Mascia, Anthony; Farr, J; Cameron, John

doi:10.1016/s1548-5315(11)70041-9

Cited by 4 publications

(6 citation statements)

References 25 publications

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“…Inevitably, this has an impact on its viability as a treatment option. This limitation is largely associated with the cost of proton centres, including installation fees, equipment and software expenses and personnel to maintain the equipment 14 . Had the findings within this study demonstrated more favourable outcomes in patients treated with proton therapy, a comprehensive cost analysis would have been suggested to consider costs arising as a result of treatment failure using EPB.…”

Section: Discussionmentioning

confidence: 97%

“…14 Had the findings within this study demonstrated more favourable outcomes in patients treated with proton therapy, a comprehensive cost analysis would have been suggested to consider costs arising as a result of treatment failure using EPB. 39 Inevitably, this has an impact on its viability as a treatment option.…”

Section: Clinical Availabilitymentioning

confidence: 93%

“…There is currently a lack of clinical availability of proton therapy facilities, and this is largely associated with the cost of proton centres. 14 Whether treatment outcomes can justify additional proton centres will also be considered.…”

Section: Normal Tissue Morbidity and Local Tumour Controlmentioning

confidence: 99%

“…Within this review, a comparison of the outcomes in patients treated with the two modalities was made to determine which treatment option is superior. There is currently a lack of clinical availability of proton therapy facilities, and this is largely associated with the cost of proton centres 14 . Whether treatment outcomes can justify additional proton centres will also be considered.…”

Section: Introductionmentioning

confidence: 99%

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Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

Appleton

Bridge

2010

J Radiother Pract

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The aims of conservative treatment in patients with ocular melanoma are globe retention, good visual acuity (VA) and local control. Two well-established radiation conservative treatment options are proton beam radiotherapy and episcleral plaque brachytherapy (EPB). Patients who receive treatment with either of these options will experience some degree of radiation-related ocular complications and poor VA. The purpose of this review of the literature is to establish whether there is a significant clinical difference in normal tissue morbidity and local tumour control between proton therapy and EPB, and whether this difference can justify the purchase and implementation of additional proton therapy facilities. Based on this review, evidence suggested that both treatment options are comparable, and that neither proton therapy nor EPB is clinically superior than the other regarding normal tissue morbidity and local tumour control. This review highlighted the need for further research on a larger scale in order to bridge the gap that is apparent within the literature.

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Section: Discussionmentioning

confidence: 97%

Section: Clinical Availabilitymentioning

confidence: 93%

Section: Normal Tissue Morbidity and Local Tumour Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

Appleton

Bridge

2010

J Radiother Pract

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“…eye structures (optic nerve, cornea, lens, retina and crystalline lens), besides reducing the enucleation rate. Eyes preservation is achieved in 90% to 95% of cases, with vision remaining functional after 5 years in approximately 50% of the patients (2) .…”

mentioning

confidence: 99%

Análise da distribuição espacial de dose absorvida em próton terapia ocular

Christóvão

Campos

2010

Radiol Bras

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OBJETIVO: Propõe-se avaliar os perfis de dose em profundidade e as distribuições espaciais de dose para protocolos de radioterapia ocular por prótons, a partir de simulações computacionais em código nuclear e modelo de olho discretizado em voxels. MATERIAIS E MÉTODOS: As ferramentas computacionais empregadas foram o código Geant4 (GEometry ANd Tracking) Toolkit e o SISCODES (Sistema Computacional para Dosimetria em Radioterapia). O Geant4 é um pacote de software livre, utilizado para simular a passagem de partículas nucleares com carga elétrica através da matéria, pelo método de Monte Carlo. Foram executadas simulações computacionais reprodutivas de radioterapia por próton baseada em instalações pré-existentes. RESULTADOS: Os dados das simulações foram integrados ao modelo de olho através do código SISCODES, para geração das distribuições espaciais de doses. Perfis de dose em profundidade reproduzindo o pico de Bragg puro e modulado são apresentados. Importantes aspectos do planejamento radioterápico com prótons são abordados, como material absorvedor, modulação, dimensões do colimador, energia incidente do próton e produção de isodoses. CONCLUSÃO: Conclui-se que a terapia por prótons, quando adequadamente modulada e direcionada, pode reproduzir condições ideais de deposição de dose em neoplasias oculares.

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Therapy of Uveal Melanoma. A Review

Rušňák¹,

Hecová²,

Kasl³

et al. 2021

CSO

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The aim of intraocular melanoma therapy is to achieve local tumor control, reduce the risk of metastasis development, preserve the eyeball and possibly the visual function of the eye. The choice of therapeutic approach requires a comprehensive view and individual approach to each patient with uveal melanoma. Factors considered include local finding (location, tumor size and shape, tumor activity, central visual acuity, intraocular complications), age and the patient‘s overall physical and psychological condition, as well as the patient‘s wishes. The most widely used method of uveal melanoma treatment is radiotherapy. The effect of radiation is caused by the absorption of ionizing radiation energy, the effect of radiation on the cell is manifested by cell death (depletion), or by a cytogenetic information change (mutation). Brachytherapy uses scleral applicators with radionuclide - ruthenium (Ru-106) applicators dominate in Europe and iodine (I-125) applicators in the USA. In external radiotherapy, the source of ionizing radiation is outside the patient‘s body. Both stereotactic radiosurgery and fractionated stereotactic radiotherapy are used. In the Czech Republic, treatment is carried out using Leksell gamma knife or CyberKnife, while proton therapy dominates in the world. The development of serious radiation complications (radiation retinopathy, neuropathy, neovascular glaucoma, toxic tumor syndrome, etc.) should be considered. Surgical therapy involves a variety of invasive procedures. Iridectomy is performed for iris melanoma. Anteriorly located choroidal melanomas and / or ciliary body melanomas can be resolved by transscleral resection (exoresection). For posterior choroidal melanomas, a combination of external tumor irradiation with pars plana vitrectomy is used. Enucleation is a method of choice in advanced tumors that cannot be effectively irradiated. Orbital exenteration is indicated in advanced tumors with extrabulbar spread or in relapsed tumor after previous enucleation.

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Proton beam radiotherapy: a specialized treatment alternative

Cited by 4 publications

References 25 publications

Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

Análise da distribuição espacial de dose absorvida em próton terapia ocular

Therapy of Uveal Melanoma. A Review

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