Proton and ion microbeam collimation for irradiation of biological samples in air

Abstract

The single cell irradiation using the tandem-type proton/ion accelerator is previewed for microdosimetry purposes in the biological media (yeast cells). Individual cells can also be targeted within a population to obtain the new in vivo data concerning a bystander effect. Usually the strong focusing systems are used for compression of the beam to µm diameter. In this work we assess the possibility to apply a simple mechanical collimator. The detailed modelling with MCNPX v.2.6 and GEANT4 v.9.1 codes shows that the 1.4-1.8 MeV proton beam energy deposition can be distributed in the 100 µm cell layer with a narrow collimator. An additional focusing system is needed for single cell irradiation. The method for calculation of the microbeam proton doses deposited in separate cells is prepared for the dose rate prediction in the 1.0-2.5 MeV proton and 3.5-3.7 MeV He 2+ ion energy range. The experimental proton beam measurements are performed and compared with modelling data.

In situanalysis of the carrier lifetime in silicon during implantation of 1.5 MeV protons

“…Implantation of protons has been performed by using the Tandetron 4110A ion accelerator [6] installed at the State Research Institute Center for Physical Sciences and Technology, Vilnius. The acceleration voltage of the latter can be enhanced up to 1.2 MV, thus, accelerated hydrogen ions can reach the energy up to 2.4 MeV.…”

Assessment of effective-medium theories of ion-beam sputtered Nb₂O₅–SiO₂ and ZrO₂–SiO₂ mixtures

“…Other methods were used to compare concentrations with optical approximations and for determining the correct model. Usually the RBS method can be trusted for precise determination of atomic concentrations of materials [25][26][27][28]. Because of precision, this technique was used as a comparison for EMA and as an indicator of the real situation.…”

“…Two sets of single-layer coatings were also analysed using a linear particle accelerator Tandetron 4110A [25]. A proton beam of 1.4 and 1.8 MeV energy was collimated to 1.5 mm spot diameter.…”