Protocolo de tratamiento de la retinopatía del prematuro en España

Novella, C. Ferrer; Viejo, I. González; Pueyo, Victoria; Fernández, R. Martínez; Galdós, Marta Barandiarán; Calvo, J. Peralta; Gómez, J. Abelairas; Palacios, Pilar Tejada; Begué, Nieves Martín; Wolley-Dod, Ch.; Portabella, S. Alarcón; Castanera, A. Serra; Ballús, M. Morales i; Castaño, Miguel Ángel Harto; Perez, R. Martinez-Costa; Rodríguez-Hurtado, Francisco Jorge; Serrano, José; Gómez, J. Escudero; Guillén, C. Morales; Ramos, M.T. Pastor; Ledesma, A. Galván; Huguet, B. Balboa; Robles, E. García; Galera, J.M. Gallardo; Marrer, B. Cabrera; Solanes, J. Castellano; Dorta, L. Cordovés; Quintana, P. Vals; Hernandez, M.A. Gil; Perez-Torres, S.; Galarza, L. Cortazar; Aldave, M.A. Ardanaz; Guri, M. Bové; Teijeiro, M.J. Blanco; Yañez, P. Mera; Campos, J. García

doi:10.1016/j.oftal.2012.07.028

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…in Spain (40). Fundus examination was performed using indirect binocular ophthalmoscopy with scleral indentation, which is currently considered the gold standard technique for complete evaluation of the retina.…”

Section: Discussionmentioning

confidence: 99%

“…As confidence intervals include the value 0, these were excluded from the calculator tool due to their low statistical significance value in the predictive model. This lack of significance could be the result of patients already being selected at the beginning of the study based on their gestational age and birth weight, according to the Screening Program for Retinopathy of Prematurity in Spain (40).…”

Section: Discussionmentioning

confidence: 99%

“…By using the screening criteria of each center or country, newborns that are subjected to serial ophthalmologic screening are identified. In each country or center, screenings are carried out on a weekly or biweekly basis (40,50), or customized to the severity of each newborn. By applying the model for predicting the risk of severe ROP requiring early treatment on the cohort of neonates, we will be able to adapt the periodicity of checkups.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical examinations performed during the present study were carried out by a single pediatric ophthalmologist based on the guidelines of the screening program for ROP in Spain ( 40 ). Fundus examination was performed using indirect binocular ophthalmoscopy with scleral indentation, which is currently considered the gold standard technique for complete evaluation of the retina.…”

Section: Discussionmentioning

confidence: 99%

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Risk Calculator for Retinopathy of Prematurity Requiring Treatment

et al. 2020

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Importance: Vascular delay that occurs early in the development of retinopathy of prematurity (ROP) is a risk factor that can be compensated by ensuring a good rate of retinal vascularization to avoid ROP that requires treatment. Background: The objective of the present study was to determine the association between ROP that requires treatment and risk factors such as the extent of the temporal avascular area of the retina and the number of days of mechanical ventilation (MV). Design: Observational retrospective case-control study. Participants: Two hundred and twenty-eight premature newborns included in the screening protocol for retinopathy of prematurity. Methods: Subjects underwent retinal examination in the 4 and 6th postnatal weeks. Main Outcome Measures : The temporal avascular area was measured in disc diameters (DD), while the MV time was measured in days of treatment. Results: Patients with a longer MV time had a higher risk of treatment (R 2 : 24.7, p < 0.0001; increase in risk of 8.1% for each additional day), as did those who showed greater avascular area (R 2 : 24.7, p < 0.0001; increase in risk of 111% for each additional DD). An online calculator system and a table are presented for calculating the risk of ROP requiring treatment as a function of these two risk factors. Conclusions and Relevance: The temporal avascular area of the retina and MV time must be taken into account in the first examination of the newborn to predict the need for ROP treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk Calculator for Retinopathy of Prematurity Requiring Treatment

et al. 2020

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“…The data were collected prospectively from the inclusion of premature infants in said protocol to the completion of the ophthalmologic monitoring, by medical discharge or death [ 15 ].…”

Section: Subjects Material and Methodsmentioning

confidence: 99%

Genetic and Environmental Influences on Retinopathy of Prematurity

Ortega-Molina

Anaya-Alaminos

Uberos‐Fernández

et al. 2015

Mediators of Inflammation

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Objective. The goals were to isolate and study the genetic susceptibility to retinopathy of prematurity (ROP), as well as the gene-environment interaction established in this disease. Methods. A retrospective study (2000–2014) was performed about the heritability of retinopathy of prematurity in 257 infants who were born at a gestational age of ≤32 weeks. The ROP was studied and treated by a single pediatric ophthalmologist. A binary logistic regression analysis was completed between the presence or absence of ROP and the predictor variables. Results. Data obtained from 38 monozygotic twins, 66 dizygotic twins, and 153 of simple birth were analyzed. The clinical features of the cohorts of monozygotic and dizygotic twins were not significantly different. Genetic factors represented 72.8% of the variability in the stage of ROP, environmental factors 23.08%, and random factors 4.12%. The environmental variables representing the highest risk of ROP were the number of days of tracheal intubation (p < 0.001), postnatal weight gain (p = 0.001), and development of sepsis (p = 0.0014). Conclusion. The heritability of ROP was found to be 0.73. The environmental factors regulate and modify the expression of the genetic code.

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